C-type lectin domain family 4 member A

Target id: 2931

Nomenclature: C-type lectin domain family 4 member A

Abbreviated Name: DCIR

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     C-type lectin domain family 4 member A has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 237 12p13.31 CLEC4A C-type lectin domain family 4 member A 1
Mouse 1 262 6 F2; 6 58.18 cM Clec4a2 C-type lectin domain family 4
Rat 1 237 4q42 Clec4a3 C-type lectin domain family 4
Gene and Protein Information Comments
Variants encoding shorter isoforms of human DCIR are reported. Two splice variants of the mouse gene encode identical shorter protein isoforms, compared to isoform 1 presented here..
Previous and Unofficial Names
CD367 | CLECSF6 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 | Dendritic cell (DC) immunoreceptor (IR) | C-type lectin domain family 4, member A3 | C-type lectin domain family 4, member a2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immuno Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Comment: 
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
innate immune response (GO:0045087) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  stimulatory C-type lectin receptor signaling pathway (GO:0002223) TAS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 

References

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1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S et al.. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol.163 (4): 1973-83. [PMID:10438934]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member A. Last modified on 16/05/2017. Accessed on 16/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2931.