Fc fragment of IgE receptor Ia

Target id: 2933

Nomenclature: Fc fragment of IgE receptor Ia

Abbreviated Name: FCεR1α

Family: Fc epsilon receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Fc fragment of IgE receptor Ia has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 257 1q23.2 FCER1A Fc fragment of IgE receptor Ia
Mouse 1 250 1 H3; 1 80.33 cM Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Rat 1 245 13q24 Fcer1a Fc fragment of IgE receptor Ia
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
IgE heavy chain Hs Binding 10.0 pKd
pKd 10.0 (Kd 1x10-10 M)
Immunopharmacology Comments
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.
Immuno Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
basophil (CL:0000767)
Comment: 
References: 
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:  
Comment:  Langerhans cells
References: 
Immuno Cell Type:  Mast cells
Cell Ontology Term:  
Comment: 
References: 
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of type I hypersensitivity (GO:0001812) IEA
IgE receptor activity (GO:0019767) IEA
Fc-epsilon receptor signaling pathway (GO:0038095) TAS
positive regulation of mast cell degranulation (GO:0043306) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  IgE receptor activity (GO:0019767) IEA
Fc-epsilon receptor signaling pathway (GO:0038095) TAS
positive regulation of mast cell degranulation (GO:0043306) IEA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of type I hypersensitivity (GO:0001812) IEA
positive regulation of mast cell degranulation (GO:0043306) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of type I hypersensitivity (GO:0001812) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of type I hypersensitivity (GO:0001812) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of interleukin-3 biosynthetic process (GO:0045401) IEA
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process (GO:0045425) IEA
References: 

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2933.