Fc fragment of IgE receptor Ia

Target id: 2933

Nomenclature: Fc fragment of IgE receptor Ia

Abbreviated Name: FCεR1α

Family: Fc epsilon receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Fc fragment of IgE receptor Ia has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 257 1q23.2 FCER1A Fc fragment of IgE receptor Ia
Mouse 1 250 1 H3; 1 80.33 cM Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Rat 1 245 13q24 Fcer1a Fc fragment of IgE receptor Ia
Previous and Unofficial Names
Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
IgE heavy chain Hs Binding 10.0 pKd
pKd 10.0 (Kd 1x10-10 M)
Immunopharmacology Comments
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
basophil (CL:0000767)
Immuno Cell Type:  Macrophages & monocytes
Comment:  Langerhans cells
Immuno Cell Type:  Mast cells
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
click arrow to show/hide IEA associations
GO:0001812 positive regulation of type I hypersensitivity IEA
GO:0019767 IgE receptor activity IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
click arrow to show/hide IEA associations
GO:0019767 IgE receptor activity IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001812 positive regulation of type I hypersensitivity IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001812 positive regulation of type I hypersensitivity IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0001812 positive regulation of type I hypersensitivity IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045401 positive regulation of interleukin-3 biosynthetic process IEA
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2933.