Fc fragment of IgE receptor II

Target id: 2935

Nomenclature: Fc fragment of IgE receptor II

Abbreviated Name: FCεRII

Family: Fc epsilon receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Fc fragment of IgE receptor II has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 321 19p13.2 FCER2 Fc fragment of IgE receptor II
Mouse 1 331 8 A1.1; 8 1.92 cM Fcer2a Fc receptor
Rat 1 331 12p12 Fcer2 Fc fragment of IgE receptor II
Gene and Protein Information Comments
There are three transcript variants of the human FCER2 gene, giving rise to two protein isoforms: FCER2a (321aa) and FCERb (320aa). We provide details for the longest protein isoform from the mouse gene, but others have been detected. Like the human gene, the rat gene produces two protein isoforms: isoform a (331aa) and isoform b (310aa).
Previous and Unofficial Names
Fc receptor, IgE, low affinity II, alpha polypeptide | CD23 | Fc epsilon RII | FcεRII
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Agonists
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Ligand Sp. Action Affinity Units Reference
IgE heavy chain Hs Binding 7.0 pKd
pKd 7.0 (Kd 1x10-7 M)
Immunopharmacology Comments
FcεRII (CD23) is the low-affinity receptor for immunoglobulin E (IgE) with a Kd > 100nM. This protein is a C-type lectin found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. It has no structural similarities with other Fc receptors. FcεRII has functions as both a membrane-bound and as a soluble receptor [2-3]. Functions include regulation of B cell growth and differentiation and of the effector phase of IgE-mediated immunity. It is also involved in regulating IgE production [3].

CD23 is used as an immunohistological diagnostic marker to differentiate chronic lymphocytic leukemia (CLL) from mantle cell leukemia [1], as most B-cell CLLs and low-grade B-cell lymphomas are CD23 +ve, whereas lymphomas arising from the mantle zone are generally CD23 -ve.
Immuno Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
Comment: 
References: 
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Comment: 
References: 
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:  
Comment:  Langerhans cells
References: 
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002925) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002925) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002925) IEA
References: 

References

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1. Barna G, Reiniger L, Tátrai P, Kopper L, Matolcsy A. (2008) The cut-off levels of CD23 expression in the differential diagnosis of MCL and CLL. Hematol Oncol26 (3): 167-70. [PMID:18381689]

2. Kikutani H, Yokota A, Uchibayashi N, Yukawa K, Tanaka T, Sugiyama K, Barsumian EL, Suemura M, Kishimoto T. (1989) Structure and function of Fc epsilon receptor II (Fc epsilon RII/CD23): a point of contact between the effector phase of allergy and B cell differentiation. Ciba Found. Symp.147: 23-31; discussion 31-5. [PMID:2695308]

3. Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T. (1988) Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression. Cell55 (4): 611-8. [PMID:2972386]

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor II. Last modified on 02/05/2017. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2935.