membrane spanning 4-domains A2

Target id: 2936

Nomenclature: membrane spanning 4-domains A2

Abbreviated Name: FCεR1β

Family: Fc epsilon receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     membrane spanning 4-domains A2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 244 11q12.1 MS4A2 membrane spanning 4-domains A2
Mouse 4 235 19 A; 19 8.46 cM Ms4a2 membrane-spanning 4-domains, subfamily A, member 2
Rat 4 243 1q43 Ms4a2 membrane spanning 4-domains A2
Gene and Protein Information Comments
The human MS4A2 gene produces two protein isoforms: isoform 1 (244aa) that traffics to the cytoplasmic membrane and isoform 3 (199aa) that triffics preferentially to the nuclear membrane. Four mouse protein isoforms are predicted.
Previous and Unofficial Names
membrane-spanning 4-domains, subfamily A, member 2 | membrane-spanning 4-domains | APY | FCεR1β | FCεRIβ | IGEL | IGER
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
The protein product of the MS4A2 gene is the β subunit of the FCεRI. It has commonly known as FCER1B. The IgE-receptor (FCεRI), is a tetramer composed of an α, β, and 2 disulfide-linked γ chains expressed on the surface of mast cells and basophils that is crucial for mediating the allergic response. It has been suggested that cytoplasmic FCER1B that is not associated with FCεRI complexes may act as a negative regulator of the signalling pathway to degranulation by sequestering important signalling partners such as the Lyn tyrosine kinase [1].
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA

References

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1. Okayama Y, Matsuda A, Kashiwakura JI, Sasaki-Sakamoto T, Nunomura S, Shimokawa T, Yamaguchi K, Takahashi S, Ra C. (2014) Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal. Clin. Exp. Allergy, 44 (2): 238-49. [PMID:24118172]

How to cite this page

Fc epsilon receptors: membrane spanning 4-domains A2. Last modified on 01/05/2017. Accessed on 18/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2936.