B7-H3 (CD276)

Target id: 2938

Nomenclature: B7-H3 (CD276)

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     B7-H3 (CD276) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 534 15q24.1 CD276 CD276 molecule 5
Mouse 1 316 9 B Cd276 CD276 antigen 5
Rat 1 316 8q24 Cd276 Cd276 molecule
Gene and Protein Information Comments
Multiple transcript variants and protein isoforms are produced from the human gene. Human B7-H3b (an isoform with four Ig-like domains that results from gene duplication and differential splicing) is the major isoform expressed in several tissues [5].
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
enoblituzumab Monkey Binding 7.7 pKd 3
pKd 7.7 (Kd 2.25x10-8 M) [3]
Description: By surface plasmon resonance (SPR) assay.
enoblituzumab Hs Binding 7.6 pKd 3
pKd 7.6 (Kd 2.45x10-8 M) [3]
Description: By surface plasmon resonance (SPR) assay
Immunopharmacology Comments
B7-H3 is a costimulatory molecule for T cell activation and IFN-γ production [1-2].
Immuno Cell Type Associations
Immuno Cell Type:  Natural killer cells
Cell Ontology Term:   natural killer cell (CL:0000623)
Comment:  B7-H3 expression is induced in NK cells by inflammatory cytokines and by phorbol myristate acetate/ionomycin exposure [1].
References: 
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
Comment:  B7-H3 expression is induced in monocytes by inflammatory cytokines and by phorbol myristate acetate/ionomycin exposure [1].
References: 
Immuno Process Associations
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IDA
T cell activation (GO:0042110) IDA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IDA
regulation of immune response (GO:0050776) NAS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of interferon-gamma biosynthetic process (GO:0045078) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IDA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell proliferation (GO:0042102) IDA
T cell activation (GO:0042110) IDA
References: 
General Comments
B7-H3 is a molecular target for oncology drug development [3-4].

References

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1. Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K et al.. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol.2 (3): 269-74. [PMID:11224528]

2. Dong C, Nurieva RI, Prasad DV. (2003) Immune regulation by novel costimulatory molecules. Immunol. Res.28 (1): 39-48. [PMID:12947223]

3. Loo D, Alderson RF, Chen FZ, Huang L, Zhang W, Gorlatov S, Burke S, Ciccarone V, Li H, Yang Y et al.. (2012) Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin. Cancer Res.18 (14): 3834-45. [PMID:22615450]

4. Nygren MK, Tekle C, Ingebrigtsen VA, Fodstad O. (2011) B7-H3 and its relevance in cancer; immunological and non-immunological perspectives. Front Biosci (Elite Ed)3: 989-93. [PMID:21622107]

5. Sun M, Richards S, Prasad DV, Mai XM, Rudensky A, Dong C. (2002) Characterization of mouse and human B7-H3 genes. J. Immunol.168 (12): 6294-7. [PMID:12055244]

How to cite this page

CD molecules: B7-H3 (CD276). Last modified on 17/07/2017. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2938.