TIGIT

Target id: 2941

Nomenclature: TIGIT

Family: Other immune checkpoint proteins, Immunoglobulin like domain containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     TIGIT has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 244 3q13.31 TIGIT T cell immunoreceptor with Ig and ITIM domains 2
Mouse 1 241 16 B4 Tigit T cell immunoreceptor with Ig and ITIM domains
Rat - - 11q21 Tigit T cell immunoreceptor with Ig and ITIM domains
Previous and Unofficial Names
T-cell immunoreceptor with Ig and ITIM domains | V-set and immunoglobulin domain containing 9 | V-set and transmembrane domain containing 3 | VSIG9 | VSTM3 | WUCAM [1]
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
TIGIT is now considered as an alternate inhibitory immune checkpoint protein which may have potential immunotherapeutic potential, particularly in conditions refractory to more established PD-1 checkpoint inhibition. Given its presence on T cells and NK cells, TIGIT offers an intervention point for targeting both the adaptive and innate arms of the immune system. Clinical development of anti-TIGIT monoclonal antibodies is in preliminary stages. Combination therapies with existing immune checkpoint inhibitors are considered particularly promising. MTIG7192A (NCT02794571; ± anti-PD-L1 atezolizumab) and BMS-986207 (NCT02913313; ± anti-PD-1 nivolumab) are two early phase potential immuno-oncology mAbs that prevent TIGIT-PVR interaction.
Cell Type Associations
Immuno Cell Type:  T cells
Comment:  Expressed on regulatory, memory and activated T cells.
References:  2
Immuno Cell Type:  Natural killer cells
References:  2
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0050868 negative regulation of T cell activation IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050868 negative regulation of T cell activation IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0032695 negative regulation of interleukin-12 production IMP
GO:0032733 positive regulation of interleukin-10 production IMP
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050868 negative regulation of T cell activation IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0050868 negative regulation of T cell activation IDA
General Comments
TIGIT was originally identified as a high affinity binding partner of the poliovirus receptor (PVR; P15151). TIGIT-PVR interaction promotes the generation of mature immunoregulatory dendritic cells and leads to suppression of T cell activation.

References

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1. Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. (2009) A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur. J. Immunol., 39 (3): 695-703. [PMID:19197944]

2. Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H et al.. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol., 10 (1): 48-57. [PMID:19011627]

How to cite this page

Other immune checkpoint proteins: TIGIT. Last modified on 30/01/2018. Accessed on 18/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2941.