MTB polyketide synthase Pks13

Target id: 2950

Nomenclature: MTB polyketide synthase Pks13

Family: Anti-infective targets

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MTB polyketide synthase Pks13 in GtoImmuPdb

Database Links
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Inhibitors
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Ligand Sp. Action Affinity Units Reference
TAM16 TB Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 1.9x10-7 M) [1]
General Comments
FAAL32-Pks13 polyketide synthase catalyzes the condensation reaction, which produces α-alkyl β-ketoacids, direct precursors of mycolic acids. This function is carried out by its thioesterase-like domain as a unique mechanism to transfer polyketide synthase products in mycobacteria, hence the focus on this as a drug target [2].

References

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1. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R et al.. (2017) Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell170 (2): 249-259.e25. [PMID:28669536]

2. Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A. (2014) The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria. Chem. Biol.21 (12): 1660-9. [PMID:25467124]

How to cite this page

Anti-infective targets: MTB polyketide synthase Pks13. Last modified on 23/08/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2950.