Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit | Antimalarial targets | IUPHAR/BPS Guide to PHARMACOLOGY

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Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit

Target not currently curated in GtoImmuPdb

  Target has curated data in GtoMPdb

Target id: 2954

Nomenclature: Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit

Abbreviated Name: PfcPheRS

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 575 cPheRS phenylalanine--tRNA ligase alpha subunit
Previous and Unofficial Names
Pfal cPheRS
Database Links

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Ligand Sp. Action Affinity Parameter Reference
BRD3444 Pf3D7 Inhibition 7.3 pIC50 1
pIC50 7.3 (IC50 4.6x10-8 M) [1]
Malaria Pharmacology Comments
The aminoacyl-tRNA synthetases are emerging targets for antimalarial agents. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes. The target described here (PfcPheRS) is unique in that it is the first member of the class whose inhibition results in elimination of blood (asexual and sexual), liver and transmission stage parasites [1].


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1. Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V et al.. (2016) Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature, 538 (7625): 344-349. [PMID:27602946]

How to cite this page

Antimalarial targets: Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit. Last modified on 28/11/2018. Accessed on 18/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY,