Plasmodium falciparum elongation factor 2 | Antimalarial targets | IUPHAR/BPS Guide to PHARMACOLOGY

Plasmodium falciparum elongation factor 2

Target id: 2975

Nomenclature: Plasmodium falciparum elongation factor 2

Abbreviated Name: PfeEF2

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Plasmodium falciparum elongation factor 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 832 eEF2 elongation factor 2
Database Links
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Affinity Units Reference
M5717 Pf3D7 Parasite growth inhibition assay - - 9.0 pEC50 1
pEC50 9.0 (EC50 1x10-9 M) [3H]-hypoxanthine incorporation assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
M5717 PfNF54 Parasite gamete formation assay - - 8.7 – 8.9 pEC50 1
pEC50 8.9 (EC50 1.2x10-9 M) Female gamete formation [1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
pEC50 8.7 (EC50 1.8x10-9 M) Male gamete formation [1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
M5717 Pb Parasite liver stage assay - - 8.8 pEC50 1
pEC50 8.8 (EC50 1.65x10-9 M) P. berghei Luciferase liver stage assay [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
M5717 PfNF54 Standard membrane feeding assay (SMFA) - - 8.0 – 8.7 pEC50 1
pEC50 8.7 (EC50 1.8x10-9 M) Indirect SMFA [1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
pEC50 8.0 (EC50 1x10-8 M) Direct SMFA [1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
General Comments
Elongation factor 2 (eEF2) catalyzes the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis in eukaryotes. Plasmodium eEF2 (PfeEF2) has been identified as a novel target for antimalarial drug development [1].

References

Show »

1. Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G et al.. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, 522 (7556): 315-20. [PMID:26085270]

How to cite this page

Antimalarial targets: Plasmodium falciparum elongation factor 2. Last modified on 18/07/2018. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2975.