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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 564 | Xq22.1 | NOX1 | NADPH oxidase 1 | |
| Mouse | 6 | 591 | X E3 | Nox1 | NADPH oxidase 1 | |
| Rat | 6 | 563 | Xq32 | Nox1 | NADPH oxidase 1 | |
| Gene and Protein Information Comments | ||||||
| The longest protein isoform of the human gene is 564 aa long, and known as NOH-1L [2]. NOH-1Lv (isoform 2) is 515 aa and isoform 3 is 527 aa. | ||||||
| Previous and Unofficial Names |
| GP91-2 | MOX1 | NOH1 | GP91 phox homolog | NADH/NADPH mitogenic oxidase subunit p65-mox |
| Database Links |
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| Alphafold | Q9Y5S8 (Hs), Q8CIZ9 (Mm), Q9WV87 (Rn) |
| ChEMBL Target | CHEMBL1287628 (Hs), CHEMBL1075231 (Rn) |
| Ensembl Gene | ENSG00000007952 (Hs), ENSMUSG00000031257 (Mm), ENSRNOG00000048706 (Rn) |
| Entrez Gene | 27035 (Hs), 237038 (Mm), 114243 (Rn) |
| Human Protein Atlas | ENSG00000007952 (Hs) |
| KEGG Gene | hsa:27035 (Hs), mmu:237038 (Mm), rno:114243 (Rn) |
| OMIM | 300225 (Hs) |
| Pharos | Q9Y5S8 (Hs) |
| RefSeq Nucleotide | NM_007052 (Hs), NM_172203 (Mm), NM_053683 (Rn) |
| RefSeq Protein | NP_008983 (Hs), NP_757340 (Mm), NP_446135 (Rn) |
| UniProtKB | Q9Y5S8 (Hs), Q8CIZ9 (Mm), Q9WV87 (Rn) |
| Wikipedia | NOX1 (Hs) |
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immuno Process Associations | ||
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1. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C et al.. (2012) Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56 (6): 2316-27. [PMID:22806357]
2. Bánfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, Sinha B, Ligeti E, Demaurex N, Krause KH. (2000) A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science, 287 (5450): 138-42. [PMID:10615049]
3. Gaggini F, Laleu B, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2011) Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem, 19 (23): 6989-99. [PMID:22041175]
4. Laleu B, Gaggini F, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2010) First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem, 53 (21): 7715-30. [PMID:20942471]
5. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem Pharmacol, 143: 25-38. [PMID:28709950]
