Top ▲

mitochondrial pyruvate carrier 1 like

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 3024

Nomenclature: mitochondrial pyruvate carrier 1 like

Systematic Nomenclature: SLC54A3

Family: SLC54 Mitochondrial pyruvate carriers

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 136 Xp11.4 MPC1L mitochondrial pyruvate carrier 1 like
Rat - - Xq12 Mpc1l mitochondrial pyruvate carrier 1-like
Previous and Unofficial Names Click here for help
Brain Protein | BRP44-like protein 2 | MPC1L | MPC1LP | SLC54A3
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC54A3 (Hs)
RESOLUTE MPC1L (Hs)
Other databases
Alphafold P0DKB6 (Hs)
Ensembl Gene ENSG00000238205 (Hs), ENSRNOG00000023163 (Rn)
Entrez Gene 347411 (Hs), 503429 (Rn)
Human Protein Atlas ENSG00000238205 (Hs)
KEGG Gene hsa:347411 (Hs), rno:503429 (Rn)
Pharos P0DKB6 (Hs)
UniProtKB P0DKB6 (Hs)
Wikipedia MPC1L (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Pyruvate N/A - - 2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
zaprinast Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 1
⤷ [1]
entacapone Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - 1
⤷ [1]
nitrofurantoin Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - 1
⤷ [1]
lonidamine Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 1
⤷ [1]
General Comments
MPC1L is a MPC1 paralogue expressed almost exclusively in the testis of placental mammals [2].

References

Show »

1. Tavoulari S, Schirris TJJ, Mavridou V, Thangaratnarajah C, King MS, Jones DTD, Ding S, Fearnley IM, Kunji ERS. (2022) Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer. Mol Metab, 60: 101469. [PMID:35278701]

2. Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. (2016) MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem, 291 (32): 16448-61. [PMID:27317664]

Contributors

Show »

How to cite this page