SLC61 Molybdate transporter family | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC61 Molybdate transporter family

SLC61 Molybdate transporter family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

3045

major facilitator superfamily domain containing 5 / SLC61A1 C Show summary »« Hide summary

Target Id

3045

Nomenclature

major facilitator superfamily domain containing 5

Systematic nomenclature

SLC61A1

Previous and unofficial names

hsMOT2

Genes

MFSD5 (Hs), Mfsd5 (Mm), Mfsd5 (Rn)

Ensembl ID

ENSG00000182544 (Hs), ENSMUSG00000045665 (Mm), ENSRNOG00000012832 (Rn)

UniProtKB AC

Q6N075 (Hs), Q921Y4 (Mm)

RESOLUTE

MFSD5 (Hs)

Substrates

molybdate [3]

Comment

MFSD5/SLC61 is a putative 12TM cell-surface protein which appears to allow the accumulation of molybdate, and where the neural expression appears to respond to changes in the diet. It is expressed in cervix, stomach, nerve and skin [3]; ubiquitous but higher in skeletal muscle, olfactory bulb [1]; blood, cortex, hypothalamus, cerebellum and spinal cord (mouse) [2].

References

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1. Fredriksson R, Nordström KJ, Stephansson O, Hägglund MG, Schiöth HB. (2008) The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett, 582 (27): 3811-6. [PMID:18948099]

2. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R. (2016) The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis. PLoS ONE, 11 (6): e0156912. [PMID:27272503]

3. Tejada-Jiménez M, Galván A, Fernández E. (2011) Algae and humans share a molybdate transporter. Proc Natl Acad Sci USA, 108 (16): 6420-5. [PMID:21464289]

How to cite this family page

Database page citation:

SLC61 Molybdate transporter family. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1013.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.