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Target not currently curated in GtoImmuPdb
Target has curated data in GtoMPdb
Target id: 3066
Nomenclature: Plasmodium falciparum serine hydroxymethyltransferase
Abbreviated Name: PfSHMT
Family: Folate biosynthesis enzymes
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Plasmodium falciparum 3D7 | - | 442 | SHMT | serine hydroxymethyltransferase | ||
| Previous and Unofficial Names |
| SHMT | Pf3D7_12_v3:1,483,501..1,486,097(+) | PFL1720w |
| Database Links |
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| Alphafold | Q8I566 (Pf3D7) |
| PlasmoDB | PF3D7_1235600 (Pf3D7) |
| UniProtKB | Q8I566 (Pf3D7) |
| Selected 3D Structures |
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| Malaria Pharmacology Comments |
| The P. falciparum enzyme serine hydroxymethyltransferase (PfSHMT) is involved in folate recycling. It is part of the deoxythymidylate synthesis cycle where dTMP is biosynthesized and the oxidized folate compounds generated are recycled by synchronized cooperation of PfSHMT and bifunctional PfDHFR-TS. PfSHMT has recently been validated as a chemically tractable antimalarial drug target [2]. |
1. Chitnumsub P, Ittarat W, Jaruwat A, Noytanom K, Amornwatcharapong W, Pornthanakasem W, Chaiyen P, Yuthavong Y, Leartsakulpanich U. (2014) The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities. Acta Crystallogr D Biol Crystallogr, 70 (Pt 6): 1517-27. [PMID:24914963]
2. Schwertz G, Witschel MC, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Amornwatcharapong W, Ittarat W, Schäfer A, Aponte RA et al.. (2018) Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold. ChemMedChem, 13 (9): 931-943. [PMID:29655285]
Folate biosynthesis enzymes: Plasmodium falciparum serine hydroxymethyltransferase. Last modified on 11/10/2021. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3066.
