ACKR4 | Chemokine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

ACKR4

Target id: 315

Nomenclature: ACKR4

Family: Chemokine receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     ACKR4 has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 350 3q22 ACKR4 atypical chemokine receptor 4
Mouse 7 350 9 F1 Ackr4 atypical chemokine receptor 4
Rat - - 8q32 Ackr4 atypical chemokine receptor 4
Previous and Unofficial Names
CCR10 | CC-CKR-11 | CKR-11 | CCR11 | PPR1 | VSHK1
Database Links
Specialist databases
GPCRDB ackr4_human (Hs), ackr4_mouse (Mm)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CCL19 {Sp: Human} Hs Agonist 8.4 pKi 1
pKi 8.4 [1]
CCL25 {Sp: Human} Hs Agonist 7.6 pKi 1
pKi 7.6 [1]
CCL21 {Sp: Human} Hs Agonist 6.9 pKi 1
pKi 6.9 [1]
CCL19 {Sp: Human} Hs Agonist 8.5 – 9.1 pEC50 1
pEC50 8.5 – 9.1 [1]
CCL21 {Sp: Human} Hs Agonist 7.9 – 8.5 pEC50 1
pEC50 7.9 – 8.5 [1]
CCL25 {Sp: Human} Hs Agonist 7.9 – 8.3 pEC50 1
pEC50 7.9 – 8.3 [1]
Agonist Comments
Although CCRL1 binds chemokines CCL19, CCL21 and CCL25 with high affinity, these chemokines are interanlised by the receptor and there is no known activation of intracellular signalling pathways. CCRL1 therefore acts as a decoy receptor for these chemokines and prevents their interactions with other chemokine receptors [1].
Immunopharmacology Comments
ACKR4 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0004950 chemokine receptor activity IDA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0005044 scavenger receptor activity IEA
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccrl1tm1Dgen Ccrl1tm1Dgen/Ccrl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:2181676  MP:0002169 no abnormal phenotype detected

References

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1. Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ et al.. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J. Biol. Chem., 288 (10): 7169-81. [PMID:23341447]

Contributors

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How to cite this page

Francoise Bachelerie, Adit Ben-Baruch, Israel F. Charo, Christophe Combadiere, Joshua M. Farber, Reinhold Förster, Gerard J. Graham, Richard Horuk, Massimo Locati, Andrew D. Luster, Alberto Mantovani, Georgios L Moschovakis, Philip M. Murphy, Robert J. B. Nibbs, Hisayuki Nomiyama, Joost J. Oppenheim, Christine A. Power, Amanda E. I. Proudfoot , Mette M. Rosenkilde, Antal Rot, Silvano Sozzani, Marcus Thelen, Osamu Yoshie, Albert Zlotnik.
Chemokine receptors: ACKR4. Last modified on 24/02/2017. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=315.