STAT transcription factors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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STAT family transcription factor proteins are phosphorylated by receptor kinases that are the receptors for cytokines and growth factors. Homo- or heterodimer phospho-STATs then translocate to the nucleus to regulate transcription of responsive genes.

Targets

3221

STAT3 (signal transducer and activator of transcription 3) Show summary »« Hide summary More detailed page go icon to follow link

signal transducer and activator of transcription 5A Show summary »« Hide summary

Target Id

3221

Nomenclature

signal transducer and activator of transcription 5A

Genes

STAT5A (Hs), Stat5a (Mm), Stat5a (Rn)

Ensembl ID

ENSG00000126561 (Hs), ENSMUSG00000004043 (Mm), ENSRNOG00000019496 (Rn)

UniProtKB AC

P42229 (Hs), P42230 (Mm), Q62771 (Rn)

Ligands

AK-2292 (Binding) pK_i 6.7 [1]

Comment

A transcription factor of the JAK-STAT signaling network that regulates the cellular response to cytokines.

STAT6 (signal transducer and activator of transcription 6) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2993
Nomenclature	signal transducer and activator of transcription 6
Common abbreviation	STAT6
Previous and unofficial names	IL-4 STAT \| interleukin-4-induced transcription factor
Genes	STAT6 (Hs), Stat6 (Mm), Stat6 (Rn)
Ensembl ID	ENSG00000166888 (Hs), ENSMUSG00000002147 (Mm), ENSRNOG00000025023 (Rn)
UniProtKB AC	P42226 (Hs), P52633 (Mm)

References

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How to cite this family page

Database page citation:

STAT transcription factors. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=990.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.