SST<sub>4</sub> receptor | Somatostatin receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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SST4 receptor

Target not currently curated in GtoImmuPdb

Target id: 358

Nomenclature: SST4 receptor

Family: Somatostatin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 388 20p11.2 SSTR4 somatostatin receptor 4 10,35,52
Mouse 7 384 2 G3 Sstr4 somatostatin receptor 4 40
Rat 7 384 3q41 Sstr4 somatostatin receptor 4 3
Previous and Unofficial Names
SRIF2B
Database Links
Specialist databases
GPCRDB ssr4_human (Hs), ssr4_mouse (Mm), ssr4_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
cortistatin-14 {Sp: Mouse, Rat}
CST-17 {Sp: Human}
SRIF-14 {Sp: Human, Mouse, Rat}
SRIF-28 {Sp: Human, Mouse, Rat}
Comments: SRIF-14 and SRIF-28 are the active fragments of precursor somatostatin. SST4 has lower affinity for SRIF-14 and SRIF-28 than the other somatostatin receptor subtypes.

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]Tyr10-CST14 Hs Full agonist 9.4 pKd 45
pKd 9.4 [45]
[125I]Tyr11-SRIF-14 Hs Full agonist 9.0 pKd 35
pKd 9.0 [35]
[125I]LTT-SRIF-28 Hs Full agonist 8.4 pKd 36
pKd 8.4 [36]
L-803,087 Hs Full agonist 9.2 pKi 36
pKi 9.2 [36]
CST-17 {Sp: Human} Hs Full agonist 8.5 – 9.6 pKi 44-45
pKi 8.5 – 9.6 [44-45]
J-2156 Hs Agonist 8.9 pKi 11
pKi 8.9 (Ki 1.2x10-9 M) [11]
SRIF-14 {Sp: Human, Mouse, Rat} Hs Full agonist 8.4 – 9.3 pKi 4,11,25,30-31,36,44-45,54
pKi 8.4 – 9.3 [4,11,25,30-31,36,44-45,54]
cortistatin-14 {Sp: Mouse, Rat} Hs Full agonist 8.6 – 8.8 pKi 44-45
pKi 8.6 – 8.8 [44-45]
SRIF-28 {Sp: Human, Mouse, Rat} Hs Full agonist 8.1 – 9.2 pKi 4,11,25,30,44-45
pKi 8.1 – 9.2 [4,11,25,30,44-45]
NNC269100 Hs Full agonist 8.2 pKi 24
pKi 8.2 (Ki 6x10-9 M) [24]
[125I]LTT-SRIF-28 Hs Full agonist 9.6 pIC50 44
pIC50 9.6 [44]
H-c[DCys-Phe-LAgl(NβMe,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH Hs Full agonist 8.5 pIC50 34
pIC50 8.5 [34]
SRIF-14 {Sp: Human, Mouse, Rat} Rn Full agonist 8.2 pIC50 51
pIC50 8.2 [51]
veldoreotide Hs Agonist 8.1 pIC50 1
pIC50 8.1 [1]
View species-specific agonist tables
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[L-Tyr8]CYN 154806 Hs Antagonist 6.2 – 6.5 pKi 28
pKi 6.2 – 6.5 [28]
PRL-2915 Hs Antagonist 6.0 pKi 18
pKi 6.0 [18]
BIM 23454 Hs Antagonist 6.5 pIC50 50
pIC50 6.5 [50]
Antagonist Comments
No selective antagonists available.
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  2,10,29,43
Secondary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
G protein (identity unknown)
Potassium channel
Calcium channel
Other - See Comments
Comments:  Activation of K+ channels and inhibition of Ca2+ channels is via Gi/Go G-proteins. Protein tyrosine phosphatase (PTP), Na+/H+ exchanger (NHE1), MAPK cascade and PLA2 activation are via unknown G-proteins.
References:  2,14-15,17,20-21,23,32,38,41,46-47,53
Tissue Distribution
Other structures: lung, kidney
Species:  Human
Technique:  Immunohistochemistry
References:  49
CNS: olfactory bulb and other olfactory structures, cerebral cortex , hippocampus , basal ganglia , amygdala, hypothalamus , cerebellum , brainstem, retina
Species:  Human
Technique:  Immunohistochemistry
References:  15,37,39,42,48
Gastrointestinal system: exocrine pancreas, stomach, duodenum
Species:  Human
Technique:  Immunohistochemistry
References:  49
Whole placenta and cytotrophoblast cells.
Species:  Human
Technique:  RT-PCR.
References:  6
Blood vessels.
Species:  Human
Technique:  PCR.
References:  8
PNS: dorsal root ganglia
Species:  Human
Technique:  Immunohistochemistry
References:  5
Endocrine system: parathyroid gland
Species:  Human
Technique:  Immunohistochemistry
References:  49
Fundic gastric mucosa of the stomach.
Species:  Rat
Technique:  RT-PCR.
References:  22
Pituitary.
Species:  Rat
Technique:  RT-PCR.
References:  9,12
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of cAMP accumulation (AC activity) in BHK cells stably transfected with human sst4 receptors.
Species:  Human
Tissue:  BHK cells.
Response measured:  Inhibition of cAMP accumulation.
References:  24
Measurement of NHE1 (Na-H exchanger) activity (pH recovery) in Ltk- cells stably expressing rat sst4 receptors.
Species:  Rat
Tissue:  Mouse fibroblast Ltk- cells.
Response measured:  Inhibition of NHE1 activity.
References:  23
Measurement of protein tyrosine phosphatase activity and cell proliferation in PC C13 thyroid cells.
Species:  Rat
Tissue:  PC C13 thyroid cells line.
Response measured:  Stimulation of protein tyrosine phosphatase activity and subsequent inhibition of cell proliferation.
References:  16
Measurement of cAMP accumulation (AC activity) in HEK 293 cells stably transfected with human sst4 receptors.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  19
Measurement of AC activity (cAMP levels) in CCL39 cells stably transfected with human sst4 receptors.
Species:  Human
Tissue:  CCL39 cells.
Response measured:  Inhibition of AC activity.
References:  43
Measurement of GIRK currents (inward potassium currents) in Xenopus oocyte cells stably transfected with rat sst4 and GIRK1 channels.
Species:  Rat
Tissue:  Xenopus oocytes.
Response measured:  Activation of GIRK current.
References:  20
Measurement of AC activity, arachidonate release (PLA2 activity), intracellular Ca2+ levels and MAPK activity in CHO-K1 cells stably transfected with rat sst4 receptors.
Species:  Rat
Tissue:  CHO-K1 cells.
Response measured:  Inhibition of AC activity, stimulation of arachidonate release (PLA2 activation), no change in Ca2+ mobilisation, and activation of MAPK cascade.
References:  2
Physiological Functions
Antiproliferation.
Species:  Rat
Tissue:  PC C13 clonal thyroid cell line.
References:  16
Enhancement of AMPA receptor-mediated currents in the hippocampus, and suggested interaction with the sst2 receptor.
Species:  Mouse
Tissue:  Hippocampus.
References:  26
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0002441 abnormal granulocyte morphology PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0002463 abnormal neutrophil physiology PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0001785 edema PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0005407 hyperalgesia PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0001952 increased airway responsiveness PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0008566 increased interferon-gamma secretion PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0008657 increased interleukin-1 beta secretion PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0005617 increased susceptibility to type IV hypersensitivity reaction PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0008560 increased tumor necrosis factor secretion PMID: 19622729 
Sstr4tm1Szo Sstr4tm1Szo/Sstr4tm1Szo
B6.129P2-Sstr4
MGI:105372  MP:0003828 pulmonary edema PMID: 19622729 

References

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1. Afargan M, Janson ET, Gelerman G, Rosenfeld R, Ziv O, Karpov O, Wolf A, Bracha M, Shohat D, Liapakis G et al.. (2001) Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin. Endocrinology, 142 (1): 477-86. [PMID:11145612]

2. Bito H, Mori M, Sakanaka C, Takano T, Honda Z, Gotoh Y, Nishida E, Shimizu T. (1994) Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. J Biol Chem, 269: 12722-12730. [PMID:8175684]

3. Bruno JF, Xu Y, Song J, Berelowitz M. (1992) Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc Natl Acad Sci U S A, 89: 11151-11155. [PMID:1360663]

4. Bruns C, Raulf F, Hoyer D, Schloos J, Lubbert H, Weckbecker G. (1996) Binding properties of somatostatin receptor subtypes. Metabolism, 45: 17-20. [PMID:8769372]

5. Bär KJ, Schurigt U, Scholze A, Segond Von Banchet G, Stopfel N, Bräuer R, Halbhuber KJ, Schaible HG. (2004) The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats. Neuroscience, 127 (1): 197-206. [PMID:15219682]

6. Caron P, Buscail L, Beckers A, Esteve JP, Igout A, Hennen G, Susini C. (1997) Expression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy. J Clin Endocrinol Metab, 82: 3771-3776. [PMID:9360539]

7. Cescato R, Erchegyi J, Waser B, Piccand V, Maecke HR, Rivier JE, Reubi JC. (2008) Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. J. Med. Chem., 51 (13): 4030-7. [PMID:18543899]

8. Curtis SB, Hewitt J, Yakubovitz S, Anzarut A, Hsiang YN, Buchan AM. (2000) Somatostatin receptor subtype expression and function in human vascular tissue. Am J Physiol Heart Circ Physiol, 278: 1815-1822. [PMID:10843877]

9. Day R, Dong W, Panetta R, Kraicer J, Greenwood MT, Patel YC. (1995) Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology, 136: 5232-5235. [PMID:7588263]

10. Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB. (1993) Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol Pharmacol, 43: 894-901. [PMID:8100352]

11. Engstrom M, Tomperi J, El-Darwish K, Ahman M, Savola JM, Wurster S. (2005) Superagonism at the human somatostatin receptor subtype 4. J Pharmacol Exp Ther, 312: 332-338. [PMID:15333679]

12. Epelbaum J, Briard N, Djordjijevic D, Dutour A, Meyerhoff W, Oliver C, Slama A, Viollet C, Zhang J. (1998) Characterization of somatostatin receptor subtypes in mammalian pituitary. Ann N Y Acad Sci, 839: 249-253. [PMID:9629161]

13. Erchegyi J, Hoeger CA, Low W, Hoyer D, Waser B, Eltschinger V, Schaer JC, Cescato R, Reubi JC, Rivier JE. (2005) Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem, 48: 507-514. [PMID:15658864]

14. Farrell SR, Rankin DR, Brecha NC, Barnes S. (2014) Somatostatin receptor subtype 4 modulates L-type calcium channels via Gβγ and PKC signaling in rat retinal ganglion cells. Channels (Austin), 8 (6): 519-27. [PMID:25483286]

15. Farrell SR, Raymond ID, Foote M, Brecha NC, Barnes S. (2010) Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4. J. Neurophysiol., 104 (3): 1347-54. [PMID:20573967]

16. Florio T, Scorizello A, Fattore M, D'Alto V, Salzano S, Rossi G, Berlingieri MT, Fusco A, Schettini G. (1996) Somatostatin inhibits PC Cl3 thyroid cell proliferation through the modulation of phosphotyrosine activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene. J Biol Chem, 271: 6129-6136. [PMID:8626400]

17. Gorham L, Just S, Doods H. (2014) Somatostatin 4 receptor activation modulates TRPV1[correction of TPRV1] currents in dorsal root ganglion neurons. Neurosci. Lett., 573: 35-9. [PMID:24810884]

18. Hocart SJ, Jain R, Murphy WA, Taylor JE, Coy DH. (1999) Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem, 42: 1863-1871. [PMID:10354394]

19. Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lubbert H. (1993) Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. FEBS Lett, 331: 53-59. [PMID:8405411]

20. Kreienkamp HJ, Honck HH, Richter D. (1997) Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1). FEBS Lett, 419: 92-94. [PMID:9426226]

21. Kreienkamp HJ, Roth A, Richter D. (1998) Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331). DNA Cell Biol., 17 (10): 869-78. [PMID:9809748]

22. Le Romancer M, Cherifi Y, Levasseur S, Laigneau JP, Peranzi G, Jais P, Lewin MJ, Reyl-Desmars F. (1996) Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae. Life Sci, 58: 1091-1098. [PMID:8622562]

23. Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber DL. (2003) Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem, 278: 15128-15135. [PMID:12566440]

24. Liu S, Tang C, Ho B, Ankersen M, Stidsen CE, Crider AM. (1998) Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J Med Chem, 41: 4693-4705. [PMID:9822540]

25. Meyerhof W. (1998) The elucidation of somatostatin receptor functions: a current view. Rev Physiol Biochem Pharmacol, 133: 55-108. [PMID:9600011]

26. Moneta D, Richichi C, Aliprandi M, Dournaud P, Dutar P, Billard JM, Carlo AS, Viollet C, Hannon JP, Fehlmann D, Nunn C, Hoyer D, Epelbaum J, Vezzani A. (2002) Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci, 16: 843-849. [PMID:12372020]

27. Nunn C, Rueping M, Langenegger D, Schuepbach E, Kimmerlin T, Micuch P, Hurth K, Seebach D, Hoyer D. (2003) Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors. Naunyn Schmiedebergs Arch Pharmacol, 367: 95-103. [PMID:12595949]

28. Nunn C, Schoeffter P, Langenegger D, Hoyer D. (2003) Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806. Naunyn Schmiedebergs Arch Pharmacol, 367: 1-9. [PMID:12616335]

29. Patel YC, Greenwood MT, Warszynska A, Panetta R, Srikant CB. (1994) All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase. Biochem. Biophys. Res. Commun., 198 (2): 605-12. [PMID:7905265]

30. Patel YC, Srikant CB. (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology, 135: 2814-2817. [PMID:7988476]

31. Poitout L, Roubert P, Contour-Galcera MO, Moinet C, Lannoy J, Pommier J, Plas P, Bigg D, Thurieau C. (2001) Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. J Med Chem, 44: 2990-3000. [PMID:11520208]

32. Qiu C, Zeyda T, Johnson B, Hochgeschwender U, de Lecea L, Tallent MK. (2008) Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. J. Neurosci., 28 (14): 3567-76. [PMID:18385315]

33. Reubi JC, Eisenwiener KP, Rink H, Waser B, Macke HR. (2002) A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors. Eur J Pharmacol, 456: 45-49. [PMID:12450568]

34. Rivier J, Erchegyi J, Hoeger C, Miller C, Low W, Wenger S, Waser B, Schaer JC, Reubi JC. (2003) Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan. J Med Chem, 46: 5579-5586. [PMID:14667212]

35. Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R. (1993) Cloning and characterization of a fourth human somatostatin receptor. Proc Natl Acad Sci U S A, 90: 4196-4200. [PMID:8483934]

36. Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science, 282: 737-740. [PMID:9784130]

37. Schreff M, Schulz S, Händel M, Keilhoff G, Braun H, Pereira G, Klutzny M, Schmidt H, Wolf G, Höllt V. (2000) Distribution, targeting, and internalization of the sst4 somatostatin receptor in rat brain. J. Neurosci., 20 (10): 3785-97. [PMID:10804219]

38. Schuelert N, Just S, Kuelzer R, Corradini L, Gorham LC, Doods H. (2015) The somatostatin receptor 4 agonist J-2156 reduces mechanosensitivity of peripheral nerve afferents and spinal neurons in an inflammatory pain model. Eur. J. Pharmacol., 746: 274-81. [PMID:25445035]

39. Schulz S, Händel M, Schreff M, Schmidt H, Höllt V. (2000) Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies. J. Physiol. Paris, 94 (3-4): 259-64. [PMID:11088003]

40. Schwabe W, Brennan MB, Hochgeschwender U. (1996) Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4). Gene, 168: 233-235. [PMID:8654950]

41. Sellers LA, Feniuk W, Humphrey PP, Lauder H. (1999) Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation. J. Biol. Chem., 274 (23): 16423-30. [PMID:10347203]

42. Selmer IS, Schindler M, Humphrey PP, Waldvogel HJ, Faull RL, Emson PC. (2000) First localisation of somatostatin sst(4) receptor protein in selected human brain areas: an immunohistochemical study. Brain Res. Mol. Brain Res., 82 (1-2): 114-25. [PMID:11042364]

43. Siehler S, Hoyer D. (1999) Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity. Naunyn Schmiedebergs Arch Pharmacol, 360: 510-521. [PMID:10598790]

44. Siehler S, Seuwen K, Hoyer D. (1998) [125I]Tyr10-cortistatin14 labels all five somatostatin receptors. Naunyn Schmiedebergs Arch Pharmacol, 357: 483-489. [PMID:9650799]

45. Siehler S, Seuwen K, Hoyer D. (1999) Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch Pharmacol, 360: 488-499. [PMID:10598788]

46. Smalley KS, Feniuk W, Humphrey PP. (1998) Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors. Br. J. Pharmacol., 125 (4): 833-41. [PMID:9831922]

47. Smalley KS, Feniuk W, Sellers LA, Humphrey PP. (1999) The pivotal role of phosphoinositide-3 kinase in the human somatostatin sst(4) receptor-mediated stimulation of p44/p42 mitogen-activated protein kinase and extracellular acidification. Biochem. Biophys. Res. Commun., 263 (1): 239-43. [PMID:10486283]

48. Stumm RK, Zhou C, Schulz S, Endres M, Kronenberg G, Allen JP, Tulipano G, Höllt V. (2004) Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia. J. Neurosci., 24 (50): 11404-15. [PMID:15601946]

49. Taniyama Y, Suzuki T, Mikami Y, Moriya T, Satomi S, Sasano H. (2005) Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study. Endocr. J., 52 (5): 605-11. [PMID:16284440]

50. Tulipano G, Soldi D, Bagnasco M, Culler MD, Taylor JE, Cocchi D, Giustina A. (2002) Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology, 143: 1218-1224. [PMID:11897676]

51. Viollet C, Bodenant C, Prunotto C, Roosterman D, Schaefer J, Meyerhof W, Epelbaum J, Vaudry H, Leroux P. (1997) Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem, 68: 2263-2272. [PMID:9166718]

52. Xu Y, Song J, Bruno JF, Berelowitz M. (1993) Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Biochem Biophys Res Commun, 193: 648-652. [PMID:8512564]

53. Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang NH, Aoe K, Kishimoto T et al.. (2014) Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma. Br. J. Cancer, 110 (9): 2232-45. [PMID:24743707]

54. Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA. (1998) Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A, 95: 10836-10841. [PMID:9724791]

Contributors

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How to cite this page

Corinne Bosquet, Justo P. Castaño, Zsolt Csaba, Pascal Dournaud, Hans-Jürgen Kreienkamp, Amelie Lupp, Shlomo Melmed, Stefan Schulz, Giovanni Tulipano, Hans-Jürgen Wester.
Somatostatin receptors: SST4 receptor. Last modified on 28/03/2019. Accessed on 19/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=358.