TPC1 | CatSper and Two-Pore channels | IUPHAR/BPS Guide to PHARMACOLOGY

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TPC1

Target not currently curated in GtoImmuPdb

Target id: 392

Nomenclature: TPC1

Family: CatSper and Two-Pore channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 0 816 12q24.13 TPCN1 two pore segment channel 1
Mouse 6 0 817 5 F Tpcn1 two pore channel 1
Rat 6 0 817 12q16 Tpcn1 two pore segment channel 1
Previous and Unofficial Names
voltage-gated Ca channel | two pore calcium channel protein 1 | two pore channel 1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
Organelle voltage-gated Na+-selective channel (Na+>>K+>>Ca2+); Required for the generation of action potential-like long depolarization in lysosomes. Voltage-dependence of activation is sensitive to luminal pH (determined from lysosomal recordings). ψ1/2 @ pH4.6 = +91 mV; ψ1/2 @ pH6.5 = +2.6 mV. Maximum activity requires PI(3,5)P2 and reduced [ATP], or depletion of extracellular amino acids.

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Concentration range (M) Holding voltage (mV) Reference
phosphatidyl (3,5) inositol bisphosphate Hs Activation 6.5 pEC50 - - 1
pEC50 6.5 (EC50 3x10-7 M) [1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Concentration range (M) Holding voltage (mV) Reference
verapamil Hs Inhibition 4.6 pIC50 - - 1
pIC50 4.6 (IC50 2.3x10-5 M) [1]
Cd2+ Hs Inhibition 3.7 pIC50 - - 1
pIC50 3.7 (IC50 1.8x10-4 M) [1]

References

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1. Cang C, Bekele B, Ren D. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat. Chem. Biol., 10 (6): 463-9. [PMID:24776928]

Contributors

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How to cite this page

David E. Clapham.
CatSper and Two-Pore channels: TPC1. Last modified on 07/07/2015. Accessed on 21/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=392.