TPC2 | CatSper and Two-Pore channels | IUPHAR/BPS Guide to PHARMACOLOGY

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TPC2

Target id: 393

Nomenclature: TPC2

Family: CatSper and Two-Pore channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for TPC2 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 0 752 11q13.2 TPCN2 two pore segment channel 2
Mouse 6 0 731 7 F5 Tpcn2 two pore segment channel 2
Rat 6 0 711 1q42 Tpcn2 two pore segment channel 2
Previous and Unofficial Names
two pore calcium channel protein 2
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
Organelle voltage-independent Na+-selective channel (Na+>>K+>>Ca2+). Sensitive to the levels of PI(3,5)P2. Activated by decreases in [ATP] or depletion of extracellular amino acids

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
phosphatidyl (3,5) inositol bisphosphate Hs Activation 6.4 pEC50 - - 1
pEC50 6.4 (EC50 4x10-7 M) [1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
verapamil Hs Inhibition 5.0 pIC50 - - 1
pIC50 5.0 (IC50 1x10-5 M) [1]
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Tpcn2Gt(YHD437)Byg Tpcn2Gt(YHD437)Byg/Tpcn2Gt(YHD437)Byg
involves: 129P2/OlaHsd * C57BL/6
MGI:2385297  MP:0003562 abnormal pancreatic beta cell physiology PMID: 19387438 

References

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1. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J et al.. (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell, 151 (2): 372-83. [PMID:23063126]

Contributors

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How to cite this page

David E. Clapham.
CatSper and Two-Pore channels: TPC2. Last modified on 06/07/2015. Accessed on 21/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=393.