B<sub>1</sub> receptor | Bradykinin receptors | IUPHAR/BPS Guide to PHARMACOLOGY

B1 receptor

Target id: 41

Nomenclature: B1 receptor

Family: Bradykinin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     B1 receptor has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 353 14q32.1-q32.2 BDKRB1 bradykinin receptor B1 12
Mouse 7 334 12 F1 Bdkrb1 bradykinin receptor, beta 1 46
Rat 7 337 6q32 Bdkrb1 bradykinin receptor B1 42
Previous and Unofficial Names
B1BKR | BKR1 | B1R | kinin B1 receptor | bradykinin receptor
Database Links
Specialist databases
GPCRDB bkrb1_human (Hs), bkrb1_mouse (Mm), bkrb1_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
bradykinin {Sp: Human, Mouse, Rat}
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat}
[des-Arg10]kallidin {Sp: Human}
[Hyp3]bradykinin {Sp: Human}
kallidin {Sp: Human}
Lys-[Hyp3]-bradykinin {Sp: Human, Mouse, Rat}
T-kinin {Sp: Human, Rat}
Comments: [Des-Arg10]kallidin is the most potent endogenous ligand
Potency order of endogenous ligands (Human)
[des-Arg10]kallidin (KNG1, P01042) > [des-Arg9]bradykinin (KNG1, P01042) = kallidin (KNG1, P01042) > bradykinin (KNG1, P01042)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[des-Arg10]kallidin {Sp: Human} Hs Full agonist 9.6 – 10.0 pKi 4,7,33
pKi 9.6 – 10.0 [4,7,33]
D-Lys0-[des-Arg10]kallidin Hs Full agonist 9.5 pKi 4
pKi 9.5 [4]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Mm Full agonist 9.2 pKi 31
pKi 9.2 [31]
[des-Arg10]kallidin {Sp: Human} Mm Full agonist 8.8 pKi 31
pKi 8.8 [31]
[des-Arg10]kallidin {Sp: Human} Rn Full agonist 8.7 – 8.9 pKi 33
pKi 8.7 – 8.9 [33]
kallidin {Sp: Human} Hs Full agonist 7.0 – 8.9 pKi 4,7,33
pKi 7.0 – 8.9 [4,7,33]
[D-Lys1,des-Arg10]kallidin Hs Full agonist 7.4 – 7.6 pKi 4
pKi 7.4 – 7.6 [4]
[des-Arg11]T-kinin Rn Full agonist 7.2 – 7.5 pKi 33
pKi 7.2 – 7.5 [33]
[Sar,D-Phe8,des-Arg9]bradykinin Rn Full agonist 7.1 – 7.4 pKi 33
pKi 7.1 – 7.4 [33]
Lys-kallidin Hs Full agonist 6.7 – 6.9 pKi 4
pKi 6.7 – 6.9 [4]
bradykinin {Sp: Human, Mouse, Rat} Mm Full agonist 6.7 pKi 31
pKi 6.7 [31]
kallidin {Sp: Human} Rn Full agonist 6.5 – 6.6 pKi 33
pKi 6.5 – 6.6 [33]
kallidin {Sp: Human} Mm Full agonist 6.3 pKi 30-31
pKi 6.3 [30-31]
[des-Phe9,des-Arg10]kallidin Hs Full agonist 6.1 – 6.2 pKi 4
pKi 6.1 – 6.2 [4]
[des-Pro8,des-Phe9,des-Arg10]kallidin Hs Full agonist 5.8 – 5.9 pKi 4
pKi 5.8 – 5.9 [4]
[des-Arg11]T-kinin Hs Full agonist 5.7 – 5.9 pKi 33
pKi 5.7 – 5.9 [33]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Hs Full agonist 5.7 – 5.8 pKi 7,33
pKi 5.7 – 5.8 [7,33]
[Sar,D-Phe8,des-Arg9]bradykinin Hs Full agonist 5.7 pKi 33
pKi 5.7 (Ki 1.99x10-6 M) [33]
T-kinin {Sp: Human, Rat} Hs Full agonist 5.2 pKi 33
pKi 5.2 [33]
bradykinin {Sp: Human, Mouse, Rat} Rn Full agonist 5.1 – 5.3 pKi 33
pKi 5.1 – 5.3 [33]
T-kinin {Sp: Human, Rat} Rn Full agonist 5.0 – 5.2 pKi 33
pKi 5.0 – 5.2 [33]
bradykinin {Sp: Human, Mouse, Rat} Hs Full agonist 4.0 pKi 4
pKi 4.0 [4]
[Leu8,des-Arg9]bradykinin Mm Partial agonist 7.3 pEC50 38
pEC50 7.3 [38]
Met-Lys-bradykinin Hs Full agonist 7.1 pIC50 40
pIC50 7.1 [40]
View species-specific agonist tables
Agonist Comments
The presence of arginine carboxypeptidases in functional systems frequently distorts the potency estimates for BK or Lys-BK on the B1 receptor, as these ligands are transformed into their respectice des-Arg9 metabolites [39].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
R-914 Hs Antagonist 8.6 pA2 27
pA2 8.6 [27]
R-715 Hs Antagonist 8.5 pA2 28
pA2 8.5 [28]
compound 11 [PMID: 12812482] Hs Antagonist 10.5 pKi 54
pKi 10.5 [54]
NPC 18565 Hs Antagonist 10.2 pKi 37
pKi 10.2 [37]
B-9958 Hs Antagonist 9.2 – 10.3 pKi 26,48
pKi 9.2 – 10.3 (Ki 6.3x10-10 – 5.1x10-11 M) [26,48]
B-9858 Hs Antagonist 8.7 – 10.4 pKi 33,37-38
pKi 8.7 – 10.4 [33,37-38]
B-10356 Hs Antagonist 8.8 – 10.2 pKi 26
pKi 8.8 – 10.2 [26]
[Leu9,des-Arg10]kallidin Hs Antagonist 9.1 – 9.3 pKi 4,7
pKi 9.1 – 9.3 [4,7]
R-715 Hs Antagonist 9.2 pKi 38
pKi 9.2 (Ki 6.3x10-10 M) [38]
compound 12 [PMID: 12723943] Hs Antagonist 9.2 pKi 56
pKi 9.2 [56]
SSR240612 Hs Antagonist 9.1 – 9.2 pKi 29
pKi 9.1 – 9.2 [29]
compound 12 [PMID: 12723943] Rn Antagonist 9.0 pKi 56
pKi 9.0 [56]
B-9858 Rn Antagonist 8.4 – 8.7 pKi 33
pKi 8.4 – 8.7 [33]
[Leu8,des-Arg9]bradykinin Mm Antagonist 8.4 pKi 31
pKi 8.4 [31]
B-9858 Mm Antagonist 8.3 pKi 38
pKi 8.3 [38]
PS020990 Hs Antagonist 8.2 pKi 32
pKi 8.2 [32]
[Leu9,des-Arg10]kallidin Mm Antagonist 8.1 pKi 31
pKi 8.1 [31]
NVP-SAA164 Hs Antagonist 7.9 – 8.1 pKi 21,50
pKi 7.9 – 8.1 [21,50]
B-9430 Hs Antagonist 7.9 pKi 38,53
pKi 7.9 [38,53]
[des-Arg10]icatibant Mm Antagonist 7.6 pKi 31
pKi 7.6 [31]
[Leu8,des-Arg9]bradykinin Rn Antagonist 7.4 – 7.7 pKi 33
pKi 7.4 – 7.7 [33]
[des-Arg10]icatibant Hs Antagonist 6.6 – 8.4 pKi 7,33
pKi 6.6 – 8.4 [7,33]
[des-Arg10]icatibant Rn Antagonist 7.4 – 7.6 pKi 33
pKi 7.4 – 7.6 [33]
R-715 Mm Antagonist 7.4 pKi 38
pKi 7.4 [38]
compound 11 [PMID: 12812482] Rn Antagonist 7.2 pKi 54
pKi 7.2 [54]
JMV1431 Hs Antagonist 7.1 pKi 1
pKi 7.1 [1]
NPC 17731 Hs Antagonist 6.9 pKi 37
pKi 6.9 [37]
icatibant Hs Antagonist 6.4 – 7.0 pKi 7,33
pKi 6.4 – 7.0 [7,33]
B-9430 Mm Antagonist 6.6 pKi 38
pKi 6.6 [38]
[Leu8,des-Arg9]bradykinin Hs Antagonist 5.8 – 7.2 pKi 2,4,7,33,40
pKi 5.8 – 7.2 [2,4,7,33,40]
icatibant Rn Antagonist 6.1 – 6.4 pKi 33
pKi 6.1 – 6.4 [33]
Ac-Lys-[MeAla6,Leu8,des-Arg9]bradykinin Hs Antagonist 6.2 pKi 38
pKi 6.2 [38]
[Leu9,des-Arg10]kallidin Hs Antagonist 8.9 pIC50 40
pIC50 8.9 [40]
chroman 28 Hs Antagonist 8.5 pIC50 15
pIC50 8.5 [15]
chroman 28 Rn Antagonist 8.3 – 8.5 pIC50 15
pIC50 8.3 – 8.5 [15]
View species-specific antagonist tables
Antagonist Comments
B-9958 is an aminopeptidase N substrate [26]. B-10356 is an aminopeptidase N inhibitor [26].
Immunopharmacology Comments
Bradykinin is a vasoactive, pain inducing and pro-inflammatory kinin released during acute inflammation, and its receptors, B1 and B2, are expressed on eosinophils, and neutrophils.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
neutrophil (CL:0000775)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002687 positive regulation of leukocyte migration IEA
GO:0006954 inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002687 positive regulation of leukocyte migration IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002687 positive regulation of leukocyte migration IEA
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
Gq/G11 family
Adenylate cyclase inhibition
Phospholipase C stimulation
References:  4
Tissue Distribution
T lymphocytes.
Species:  Human
Technique:  RT-PCR, Western blot.
References:  47
Lung fibroblasts.
Species:  Human
Technique:  Immunohistochemistry.
References:  49
Gastric mucosa.
Species:  Human
Technique:  Immunohistochemistry.
References:  9
Prostatic intraepithelial neoplasia and malignant lesions.
Species:  Human
Technique:  Immunohistochemistry.
References:  55
Dorsal root ganglion primary afferent terminations.
Species:  Rat
Technique:  Immunohistochemistry.
References:  22
Thalamus and hypothalamus > cortical regions and hippocampus.
Species:  Rat
Technique:  Autoradiography and in situ hybridization.
References:  10
Laminae 1 and 2 of the dorsal horn of the spinal cord, peripheral nerve terminals in the bladder, dorsal root ganglion.
Species:  Rat
Technique:  Immunohistochemistry.
References:  57
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of intracellular Ca2+ in human monocyte-derived dendritic cells endogenously expressing the B1 receptor.
Species:  Human
Tissue:  Monocyte-derived dendritic cells.
Response measured:  Increase in intracellular Ca2+.
References:  8
Measurement of intracellular Ca2+ in rat mesangial cells endogenously expressing the B1 receptor.
Species:  Rat
Tissue:  Mesangial cells.
Response measured:  Elevation of intracellular Ca2+.
References:  6
Measurement of phosphorylation of MAP kinase in rat vascular smooth muscle cells endogenously expressing the B1 receptor.
Species:  Rat
Tissue:  Vascular smooth muscle cells.
Response measured:  Phosphorylation of MAP kinase.
References:  13
Physiological Functions
Contol of inflammatory pain conditions.
Species:  Mouse
Tissue:  In vivo.
References:  21
Inhibition of arterial smooth muscle cell migration.
Species:  Human
Tissue:  Arterial smooth muscle.
References:  41
Activation of neutrophil recruitment.
Species:  Human
Tissue:  Neutrophils isolated from peripheral blood.
References:  18
Modulation of blood pressure.
Species:  Rat
Tissue:  In vivo.
References:  17
Modulation of hyperalgesia.
Species:  Rat
Tissue:  In vivo.
References:  22
Mediation of acute nociception.
Species:  Rat
Tissue:  In vivo.
References:  14
Activation of B1 receptors in the kindled rat hippocampus results in increase extracellular glutamate levels.
Species:  Rat
Tissue:  Kindled hippocampus.
References:  51
B1 blocking inhibits plasma extravasation in streptozotocin-induced diabetic rats.
Species:  Rat
Tissue:  In vivo.
References:  36
Modulation of vascular permeability of the skin and retina of type 1 diabetic rats.
Species:  Rat
Tissue:  In vivo.
References:  35
Modulation of antigen-induced pulmonary inflammation in mice.
Species:  Mouse
Tissue:  In vivo.
References:  19
B1 receptor blockade causes antinociception in induced hyperalgesia.
Species:  Rat
Tissue:  In vivo.
References:  43
Prevention of the insulitis and renal damage in a model of insulin-dependent diabetes.
Species:  Rat
Tissue:  In vivo.
References:  58
Physiological Consequences of Altering Gene Expression
Mice lacking the B1 receptor display hypoalgesia and altered inflammatory responses when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  45
B1 knockout mice display reduced nerve injury-induced neuropathic pain when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  20
B1 receptor knockout mice display hypoalgesia and altered inflammatory responses when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  45
B1 knockout mice display lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B1 mice also present pancreas abnormalities, which lead to hypoinsulinemia and reduced insulin release after a glucose load.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  3
B1 knockout mice display reduced pancreatic vascular permeability when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  3
Diabetic hyperalgesia is absent in streptozotocin-induced type 1 diabetic B1 receptor knockout mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  23-25
Mice lacking both the B1 and B2 receptor are normotensive and protected from endotoxin- induced hypotension when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  11
B1 receptor knockout mice display worsened myocardial ischemia when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  34
B1 knockout mice display altered inflammatory responses following intestinal ischemia and reperfusion injury, when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  52
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002498 abnormal acute inflammation PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0002135 abnormal kidney morphology PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002734 abnormal mechanical nociception PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0004756 abnormal proximal convoluted tubule morphology PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002733 abnormal thermal nociception PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005566 decreased blood urea nitrogen level PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0001982 decreased chemically-elicited antinociception PMID: 10859349 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0005333 decreased heart rate PMID: 16497152 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 16497152 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0008734 decreased susceptibility to endotoxin shock PMID: 16497152 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008734 decreased susceptibility to endotoxin shock PMID: 16497152 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0003043 hypoalgesia PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005565 increased blood urea nitrogen level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005553 increased circulating creatinine level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 17452647 
Bdkrb1tm1Dgen Bdkrb1tm1Dgen/Bdkrb1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:88144  MP:0002169 no abnormal phenotype detected
Bdkrb1tm1(BDKRB1)Jfh Bdkrb1tm1(BDKRB1)Jfh/Bdkrb1tm1(BDKRB1)Jfh
involves: 129 * C57BL/6
MGI:88144  MP:0002169 no abnormal phenotype detected PMID: 16497152 
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Description:  The B1 receptor polymorphism -699 G/C has been associated with renal disease.
References:  5
Type:  Single nucleotide polymorphism
Species:  Human
Description:  The -699 G/C polymorphism has been found to be a predictor of cardiovascular risk in hypertension.
References:  16
General Comments
B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy [44].

References

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1. Amblard M, Bedos P, Olivier C, Daffix I, Luccarini JM, Dodey P, Pruneau D, Paquet JL, Martinez J. (2000) Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem, 43: 2382-2386. [PMID:10882364]

2. Aramori I, Zenkoh J, Morikawa N, O'Donnell N, Asano M, Nakamura K, Iwami M, Kojo H, Notsu Y. (1997) Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol, 51: 171-176. [PMID:9203620]

3. Araújo RC, Mori MA, Merino VF, Bascands JL, Schanstra JP, Zollner RL, Villela CA, Nakaie CR, Paiva AC, Pesquero JL, Bader M, Pesquero JB. (2006) Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function. Biol Chem, 387: 431-436. [PMID:16606341]

4. Austin CE, Faussner A, Robinson HE, Chakravarty S, Kyle DJ, Bathon JM, Proud D. (1997) Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways. J Biol Chem, 272: 11420-11425. [PMID:9111052]

5. Bachvarov DR, Landry M, Pelletier I, Chevrette M, Betard C, Houde I, Bergeron J, Lebel M, Marceau F. (1998) Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure. J Am Soc Nephrol, 9: 598-604. [PMID:9555662]

6. Bascands JL, Pecher C, Rouaud S, Emond C, Tack JL, Bastie MJ, Burch R, Regoli D, Girolami JP. (1993) Evidence for existence of two distinct bradykinin receptors on rat mesangial cells. Am J Physiol, 264: F548-F556. [PMID:8384416]

7. Bastian S, Loillier B, Paquet JL, Pruneau D. (1997) Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization. Br J Pharmacol, 122: 393-399. [PMID:9313952]

8. Bertram CM, Baltic S, Misso NL, Bhoola KD, Foster PS, Thompson PJ, Fogel-Petrovic M. (2007) Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration. J Leukoc Biol,: -. [PMID:17327486]

9. Bhoola R, Ramsaroop R, Naidoo S, Müller-Esterl W, Bhoola KD. (1997) Kinin receptor status in normal and inflammed gastric mucosa. Immunopharmacology, 36: 161-165. [PMID:9228541]

10. Campos MM, Ongali B, De Souza Buck H, Schanstra JP, Girolami JP, Chabot JG, Couture R. (2005) Expression and distribution of kinin B1 receptor in the rat brain and alterations induced by diabetes in the model of streptozotocin. Synapse, 57: 29-37. [PMID:15858836]

11. Cayla C, Todiras M, Iliescu R, Saul VV, Gross V, Pilz B, Chai G, Merino VF, Pesquero JB, Baltatu OC, Bader M. (2007) Mice deficient for both kinin receptors are normotensive and protected from endotoxin- induced hypotension. FASEB J,: -. [PMID:17289925]

12. Chai KX, Ni A, Wang D, Ward DC, Chao J, Chao L. (1996) Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. Genomics, 31: 51-57. [PMID:8808279]

13. Christopher J, Velarde V, Jaffa AA. (2001) Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension, 38: 602-605. [PMID:11566939]

14. Conley RK, Wheeldon A, Webb JK, DiPardo RM, Homnick CF, Bock MG, Chen TB, Chang RS, Pettibone DJ, Boyce S. (2005) Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist. Eur J Pharmacol, 527: 44-51. [PMID:16310181]

15. D'Amico DC, Aya T, Human J, Fotsch C, Chen JJ, Biswas K, Riahi B, Norman MH, Willoughby CA, Hungate R, Reider PJ, Biddlecome G, Lester-Zeiner D, Staden CV, Johnson E, Kamassah A, Arik L, Wang J, Viswanadhan VN, Groneberg RD, Zhan J, Suzuki H, Toro A, Mareska DA, Clarke DE, Harvey DM, Burgess LE, Laird ER, Askew B, Ng G. (2007) Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem, 50: 607-610. [PMID:17243660]

16. Dhamrait SS, Payne JR, Li P, Jones A, Toor IS, Cooper JA, Hawe E, Palmen JM, Wootton PT, Miller GJ, Humphries SE, Montgomery HE. (2003) Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. Eur Heart J, 24: 1672-1680. [PMID:14499231]

17. Duka A, Duka I, Gao G, Shenouda S, Gavras I, Gavras H. (2006) Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. Am J Physiol Endocrinol Metab, 291: E268-E274. [PMID:16507603]

18. Ehrenfeld P, Millan C, Matus CE, Figueroa JE, Burgos RA, Nualart F, Bhoola KD, Figueroa CD. (2006) Activation of kinin B1 receptors induces chemotaxis of human neutrophils. J Leukoc Biol, 80: 117-124. [PMID:16670123]

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Joseph Coulson, Alexander Faussner, Fredrik Leeb-Lundberg, Francois Marceau, Werner Muller-Esterl, Doug Pettibone, Bruce Zuraw.
Bradykinin receptors: B1 receptor. Last modified on 19/02/2018. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=41.