GABA<sub>A</sub> receptor ρ2 subunit | GABA<sub>A</sub> receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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GABAA receptor ρ2 subunit

Target not currently curated in GtoImmuPdb

Target id: 421

Nomenclature: GABAA receptor ρ2 subunit

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 490 6q13-q16.3 GABRR2 gamma-aminobutyric acid type A receptor rho2 subunit 1
Mouse 4 490 4 A5 Gabrr2 gamma-aminobutyric acid (GABA) C receptor 1
Rat 4 465 5q21 Gabrr2 gamma-aminobutyric acid type A receptor rho 2 subunit 2
Previous and Unofficial Names
GABA(A) receptor subunit rho-2 | gamma-aminobutyric acid receptor subunit rho-2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | gamma-aminobutyric acid (GABA) C receptor
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
(±)-cis-2-CAMP Hs Full agonist - -
[Binds to: GABA site]
5-Me-IAA Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Hs Partial agonist - -
[Binds to: GABA site]
muscimol Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
cis-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
trans-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Hs Antagonist - -
[Binds to: GABA site]
TPMPA Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Hs - no - - - no

Not voltage dependent
TBPS Hs - no - - - no

Not voltage dependent

References

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1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. (1992) Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics, 12 (4): 801-6. [PMID:1315307]

2. Ogurusu T, Taira H, Shingai R. (1995) Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. J. Neurochem., 65 (3): 964-8. [PMID:7643126]

Contributors

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How to cite this page

Delia Belelli, Tim G. Hales, Jeremy J. Lambert, Bernhard Luscher, Richard Olsen, John A. Peters, Uwe Rudolph, Werner Sieghart.
GABAA receptors: GABAA receptor ρ2 subunit. Last modified on 21/03/2019. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421.