GABA<sub>A</sub> receptor ρ3 subunit | GABA<sub>A</sub> receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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GABAA receptor ρ3 subunit

Target id: 422

Nomenclature: GABAA receptor ρ3 subunit

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GABAA receptor ρ3 subunit in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 467 3q11.2 GABRR3 gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) 1
Mouse 4 464 16 C1.3 Gabrr3 gamma-aminobutyric acid (GABA) receptor, rho 3 3
Rat 4 464 11q12 Gabrr3 gamma-aminobutyric acid type A receptor rho3 subunit 2
Previous and Unofficial Names
GABA(A) receptor subunit rho-3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid (GABA) receptor
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
(±)-cis-2-CAMP Hs Full agonist - -
[Binds to: GABA site]
5-Me-IAA Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Hs Partial agonist - -
[Binds to: GABA site]
muscimol Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cis-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
trans-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Hs Antagonist - -
[Binds to: GABA site]
TPMPA Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Hs - no - - - no

Not voltage dependent
TBPS Hs - no - - - no

Not voltage dependent

References

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1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG. (1999) Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. Biochim. Biophys. Acta, 1447 (2-3): 307-12. [PMID:10542332]

2. Ogurusu T, Shingai R. (1996) Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Biochim. Biophys. Acta, 1305 (1-2): 15-8. [PMID:8605242]

3. Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008) PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol. Cell. Neurosci., 37 (4): 808-19. [PMID:18325784]

Contributors

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How to cite this page

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: GABAA receptor ρ3 subunit. Last modified on 10/11/2014. Accessed on 21/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422.