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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 2 | 444 | 17p13.2 | P2RX5 | purinergic receptor P2X 5 | 3,10-11 |
| Mouse | 2 | 455 | 11 B4 | P2rx5 | purinergic receptor P2X, ligand-gated ion channel, 5 | 7 |
| Rat | 2 | 455 | 10q24 | P2rx5 | purinergic receptor P2X 5 | 6 |
| Gene and Protein Information Comments | ||||||
| Seventy-five P2X5 genes have been identified in the genomes of 75 placental mammalian species (Eutheria) [14]. | ||||||
| Previous and Unofficial Names |
| P2X purinoceptor 5 | purinergic receptor P2X, ligand gated ion channel, 5 | purinergic receptor P2X |
| Database Links |
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| Alphafold | Q93086 (Hs), Q3UYI1 (Mm), P51578 (Rn) |
| CATH/Gene3D | 2.60.490.10 |
| ChEMBL Target | CHEMBL4942 (Hs), CHEMBL2495 (Rn) |
| Ensembl Gene | ENSG00000083454 (Hs), ENSMUSG00000005950 (Mm), ENSRNOG00000019208 (Rn) |
| Entrez Gene | 5026 (Hs), 94045 (Mm), 113995 (Rn) |
| Human Protein Atlas | ENSG00000083454 (Hs) |
| KEGG Gene | hsa:5026 (Hs), mmu:94045 (Mm), rno:113995 (Rn) |
| OMIM | 602836 (Hs) |
| Pharos | Q93086 (Hs) |
| RefSeq Nucleotide | NM_002561 (Hs), NM_033321 (Mm), NM_080780 (Rn) |
| RefSeq Protein | NP_002552 (Hs), NP_201578 (Mm), NP_542958 (Rn) |
| UniProtKB | Q93086 (Hs), Q3UYI1 (Mm), P51578 (Rn) |
| Wikipedia | P2RX5 (Hs) |
| Natural/Endogenous Ligands |
| ATP |
| Comments: Endogenous agonist: ATP at human [3] and mouse [7] P2X5 receptors. |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [4-5]. |
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| Physiological Consequences of Altering Gene Expression
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| General Comments |
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The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa). Of all the functional P2X receptors, only P2X5 homopolymer is unregulated by intracellular PIPn [1-2]. |
1. Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. (2010) Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit. J Neurochem, 113 (6): 1676-84. [PMID:20374427]
2. Bernier LP, Ase AR, Séguéla P. (2013) Post-translational regulation of P2X receptor channels: modulation by phospholipids. Front Cell Neurosci, 7: 226. [PMID:24324400]
3. Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA. (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol, 63 (6): 1407-16. [PMID:12761352]
4. Burnstock G, Boeynaems JM. (2014) Purinergic signalling and immune cells. Purinergic Signal, 10 (4): 529-64. [PMID:25352330]
5. Cekic C, Linden J. (2016) Purinergic regulation of the immune system. Nat Rev Immunol, 16 (3): 177-92. [PMID:26922909]
6. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci, 16 (8): 2495-507. [PMID:8786426]
7. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene, 270 (1-2): 145-52. [PMID:11404011]
8. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem, 45 (19): 4057-93. [PMID:12213051]
9. Kim H, Walsh MC, Takegahara N, Middleton SA, Shin HI, Kim J, Choi Y. (2017) The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Sci Rep, 7 (1): 196. [PMID:28298636]
10. Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S, Chanda PK, Bowlby MR, Kaftan EJ, Samad TA et al.. (2010) Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform. Mol Pharmacol, 77 (6): 953-60. [PMID:20223879]
11. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett, 418 (1-2): 195-9. [PMID:9414125]
12. Przybyła T, Sakowicz-Burkiewicz M, Pawełczyk T. (2018) Purinergic signaling in B cells. Acta Biochim Pol, 65 (1): 1-7. [PMID:29360885]
13. Vaeth M, Feske S. (2018) Ion channelopathies of the immune system. Curr Opin Immunol, 52: 39-50. [PMID:29635109]
14. Zdobnov EM, Tegenfeldt F, Kuznetsov D, Waterhouse RM, Simão FA, Ioannidis P, Seppey M, Loetscher A, Kriventseva EV. (2017) OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs. Nucleic Acids Res, 45 (D1): D744-D749. [PMID:27899580]
target has curated data in GtoImmuPdb
