Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	2	313	19q13.2	KCNK6	potassium two pore domain channel subfamily K member 6	1,3
Mouse	4	2	313	7 B1	Kcnk6	potassium inwardly-rectifying channel, subfamily K, member 6
Rat	4	2	313	1q21	Kcnk6	potassium two pore domain channel subfamily K member 6

Previous and Unofficial Names

TOSS | potassium channel subfamily K member 6 (TWIK-2) | potassium channel, two pore domain subfamily K, member 6 | potassium inwardly-rectifying channel

Database Links
Alphafold	Q9Y257 (Hs)
Ensembl Gene	ENSG00000099337 (Hs), ENSMUSG00000046410 (Mm), ENSRNOG00000020598 (Rn)
Entrez Gene	9424 (Hs), 52150 (Mm), 116491 (Rn)
Human Protein Atlas	ENSG00000099337 (Hs)
KEGG Gene	hsa:9424 (Hs), mmu:52150 (Mm), rno:116491 (Rn)
OMIM	603939 (Hs)
Pharos	Q9Y257 (Hs)
RefSeq Nucleotide	NM_004823 (Hs), NM_001033525 (Mm), NM_053806 (Rn)
RefSeq Protein	NP_004814 (Hs), NP_001028697 (Mm), NP_446258 (Rn)
UniProtKB	Q9Y257 (Hs)
Wikipedia	KCNK6 (Hs)

Functional Characteristics
Unknown

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Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference quinidine Rn - - pIC50 < 1x10-4 - 2 ⤷ pIC50 Conc range: < 1x10-4 M [2] Ba2+ Rn - - pIC50 1x10-5 - 1x10-4 - 2 ⤷ pIC50 Conc range: 1x10-5 - 1x10-4 M [2]

Tissue Distribution
Pancreas, placenta and heart Species:  Human Technique:  Northern Blot References:  3
Liver Species:  Mouse Technique:  Northern Blot References:  3

General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. Displays time-dependent inactivation at depolarized potentials [2]. The rat variant has been reported to be widely expressed (including brain, lung, kidney, liver, spleen, heart, oesophagus, stomach, colon, skeletal muscle).