K<sub>2P</sub>13.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

K2P13.1

Target id: 523

Nomenclature: K2P13.1

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for K2P13.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 408 14q31-q32 KCNK13 potassium two pore domain channel subfamily K member 13 3
Mouse 4 2 405 12 E Kcnk13 potassium channel, subfamily K, member 13
Rat 4 2 405 6q32 Kcnk13 potassium two pore domain channel subfamily K member 13
Previous and Unofficial Names
THIK-1 | prdx1 | tandem pore domain halothane-inhibited potassium channel 1 | potassium channel, two pore domain subfamily K, member 13 | potassium channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
K2P12.1 1
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Associated Protein Comments
Heterodimerization of K2P12 and K2P13 was recently reported in a heterologous expression system [1].

N-terminal endoplasmic retention signal has been reported [2,4] but no protein partners identified.
Functional Characteristics
Background current

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
arachidonic acid N/A - - - 1x10-3 - 1
Conc range: 1x10-3 M studied at ~5 µM [1]
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
halothane Hs - - - - - 1
studied at ~5 mM [1]
Channel Blockers
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
Ba2+ N/A - - - - -
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. K2P13 like channels are found in the central nervous system of Aplysia californica.

References

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1. Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D. (2014) Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. J. Biol. Chem., 289 (41): 28202-12. [PMID:25148687]

2. Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F. (2013) Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. J. Biol. Chem., 288 (49): 35081-92. [PMID:24163367]

3. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C. (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem., 276 (10): 7302-11. [PMID:11060316]

4. Renigunta V, Zou X, Kling S, Schlichthörl G, Daut J. (2014) Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflugers Arch., 466 (9): 1735-45. [PMID:24297522]

Contributors

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How to cite this page

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein.
Two P domain potassium channels: K2P13.1. Last modified on 09/03/2017. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=523.