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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 24 | 0 | 2313 | 1q25.3 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | |
| Mouse | 24 | 0 | 2272 | 1 66.14 cM | Cacna1e | calcium channel, voltage-dependent, R type, alpha 1E subunit | |
| Rat | 24 | 0 | 2222 | 13q21 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | |
| Previous and Unofficial Names |
| α1E | CACH6 | CACNL1A6 | brain calcium channel II | CACHA1E | calcium channel, L type, alpha-1 polypeptide, isoform 6 | RBE2 | RBE-II | alpha1E | Cchra1 | BII-1 | calcium channel |
| Database Links |
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| Alphafold | Q15878 (Hs), Q61290 (Mm), Q07652 (Rn) |
| ChEMBL Target | CHEMBL1687682 (Hs) |
| Ensembl Gene | ENSG00000198216 (Hs), ENSMUSG00000004110 (Mm), ENSRNOG00000002863 (Rn) |
| Entrez Gene | 777 (Hs), 12290 (Mm), 54234 (Rn) |
| Human Protein Atlas | ENSG00000198216 (Hs) |
| KEGG Gene | hsa:777 (Hs), mmu:12290 (Mm), rno:54234 (Rn) |
| OMIM | 601013 (Hs) |
| Pharos | Q15878 (Hs) |
| RefSeq Nucleotide | NM_000721 (Hs), NM_009782 (Mm), NM_019294 (Rn) |
| RefSeq Protein | NP_000712 (Hs), NP_033912 (Mm), NP_062167 (Rn) |
| UniProtKB | Q15878 (Hs), Q61290 (Mm), Q07652 (Rn) |
| Wikipedia | CACNA1E (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| R-type calcium current: Moderate voltage-activated, fast voltage-dependent inactivation | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Voltage Dependence Comments | ||||||||||||||||
| Coexpression of Cav2.3 with β1, β3 or β4 subunits shifts the voltage-dependence of activation and inactivation further in the hyperpolarised direction [32,42]. Activation and inactivation time courses depend upon the nature of the β subunit, being slower with β2 [32]. |
Download all structure-activity data for this target as a CSV file 
| Gating inhibitors
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Ni2+ blockade is detected as both a reduction in the maximum slope conductance and a shift in the current-voltage relation [60]. SNX482 has also been shown to block native IA potassium currents and cloned Kv4.3 currents at lower concentrations than that required for blockade of Cav2.3 currents [15]. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific channel blocker tables | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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| Clinically-Relevant Mutations and Pathophysiology
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