K<SUB>v</SUB>1.7 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv1.7

Target id: 544

Nomenclature: Kv1.7

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv1.7 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 456 19q13.3 KCNA7 potassium voltage-gated channel subfamily A member 7 5
Mouse 6 1 532 7 B4 Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 5
Rat 6 1 457 1q22 Kcna7 potassium voltage-gated channel subfamily A member 7 5
Previous and Unofficial Names
HAK6 | KCNA7 | potassium voltage-gated channel subfamily A member 7 | potassium channel, voltage gated shaker related subfamily A, member 7 | potassium voltage-gated channel
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
KV
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+ [21.0 pS]
References:  5
Species:  Mouse
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  5
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 - 5 RBL Cells Mouse
Inactivation  - 14.0 5
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 5.8 1 COS-7 Mouse
Inactivation  - -
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -4.3 - 4 Xenopus laevis oocyte Mouse
Inactivation  -21.0 181.8 4
Comments  mKV1.7L isoform.
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  4.4 - 4 Xenopus laevis oocyte Mouse
Inactivation  -40.0 643.2 4
Comments  mKV1.7S isoform.
Associated subunits (Human)
Kv β1 and Kv β2

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
flecainide Hs - 5.1 pKd - - 1
pKd 5.1 [1]
quinidine Hs - 4.8 pKd - - 1
pKd 4.8 [1]
verapamil Hs - 4.8 pKd - - 1
pKd 4.8 [1]
amiodarone Hs - 4.5 pKd - - 1
pKd 4.5 [1]
tetraethylammonium Hs - 4.1 pKd - - 1
pKd 4.1 [1]
fampridine Mm Pore blocker 3.8 pKd - - 4
pKd 3.8 [4]
ShK Toxin Mm - 7.9 pIC50 - - 5
pIC50 7.9 [5]
noxiustoxin Mm - 7.7 pIC50 - - 5
pIC50 7.7 [5]
margatoxin Mm - 6.9 pIC50 - - 5
pIC50 6.9 [5]
conkunitzin-S1 toxin Mm Pore blocker 6.4 pIC50 - - 3
pIC50 6.4 (IC50 4.39x10-7 M) [3]
CP-339818 Mm - 5.0 pIC50 - - 5
pIC50 5.0 [5]
nifedipine Mm - 4.9 pIC50 - - 5
pIC50 4.9 [5]
resiniferatoxin Mm - 4.7 pIC50 - - 5
pIC50 4.7 [5]
tedisamil Mm - 4.7 pIC50 - - 5
pIC50 4.7 [5]
capsaicin Mm - 4.6 pIC50 - - 5
pIC50 4.6 [5]
diltiazem Mm - 4.2 pIC50 - - 5
pIC50 4.2 [5]
fampridine Mm - 3.6 pIC50 - - 5
pIC50 3.6 (IC50 2.45x10-4 M) [5]
cromakalim Mm - 3.3 pIC50 - - 5
pIC50 3.3 [5]
tetraethylammonium Mm - 1.1 pIC50 - - 5
pIC50 1.1 [5]
View species-specific channel blocker tables
Tissue Distribution
Heart, skeletal muscle > liver, lung > placenta, brain, islets > spleen, kidney, testes.
Species:  Mouse
Technique:  RT-PCR
References:  5
Heart, lung > brain.
Species:  Rat
Technique:  RT-PCR
References:  2
Pancreatic β-cells
Species:  Rat
Technique: 
References:  3
Functional Assays
Voltage clamp of cloned mouse channel expressed in RBL cells reveals A-type K+ current.
Species:  Mouse
Tissue:  RBL Cells.
Response measured:  A-type potassium current.
References:  5
Voltage clamp of cloned human channel expressed in COS-7 cells reveals similarity to IKur current.
Species:  Human
Tissue:  COS-7 Cells.
Response measured:  IKur like current.
References:  1
Physiological Functions
KV1.7 plays an important role in the repolarization of cell membranes.
Species:  Human
Tissue:  Cell membrane.
References:  6
KV1.7 has properties similar to the ultra-rapidly activating IKur current in the heart.
Species:  Human
Tissue:  Heart.
References:  1
KV1.7 regulates glucose-stimulated insulin secretion
Species:  Rat
Tissue:  Pancreatic beta cells
References:  3
Biologically Significant Variant Comments
A total of 198 SNPs have been identified in human KCNG4. For more information please see the entry on GeneCards.
General Comments
Can co-assemble with other KV1 family members in heteromultimers, but not with members of other KV families. Unlike the other known Kv1 family members, the gene for Kv1.7 has a 1.9Kb intron in the coding region [1,5-6].

References

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1. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. (2002) Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur. J. Hum. Genet., 10 (1): 36-43. [PMID:11896454]

2. Davies AR, Kozlowski RZ. (2001) Kv channel subunit expression in rat pulmonary arteries. Lung, 179 (3): 147-61. [PMID:11891605]

3. Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Strüver N, Pavlov E, Nichols CG, French RJ, Terlau H. (2012) Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med, 4 (5): 424-34. [PMID:22438204]

4. Finol-Urdaneta RK, Strüver N, Terlau H. (2006) Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms. J. Gen. Physiol., 128 (1): 133-45. [PMID:16801386]

5. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J. Biol. Chem., 273 (10): 5851-7. [PMID:9488722]

6. Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlestedt C, Wasserman WW, Zabarovsky ER. (2001) Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene, 268 (1-2): 115-22. [PMID:11368907]

Contributors

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How to cite this page

James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv1.7. Last modified on 13/03/2017. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=544.