Retinoic acid receptor-β

Nomenclature: Retinoic acid receptor-β

Systematic Nomenclature: NR1B2

Family: 1B. Retinoic acid receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 448 3p24 RARB retinoic acid receptor, beta 2,29
Mouse 448 14A Rarb retinoic acid receptor, beta 29,31,48-49
Rat - 15 Rarb retinoic acid receptor, beta 29
Previous and Unofficial Names
HAP
RRB2
retinoic acid receptor beta
RARβ
HBV-activated protein
NR1B2
retinoic acid receptor, beta
RAR beta 2
RARbeta2
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  RAR-β (ligand-binding domain)
PDB Id:  1XAP
Ligand:  TTNPB
Resolution:  2.1Å
Species:  Human
References:  12
Natural/Endogenous Ligands
tretinoin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CD666 Hs Agonist 5.64 pKd 1
pKd 5.64 [1]
alitretinoin Hs Agonist 9.7 pKi 17,32
pKi 9.7 [17,32]
tretinoin Hs Agonist 9.4 pKi 16-17,32,40
pKi 9.4 [16-17,32,40]
adapalene Hs Agonist 7.47 pKi 4
pKi 7.47 (Ki 3.4x10-8 M) [4]
Description: Binding affinity to RARβ using [3H]CD 367 as radioligand.
tazarotene Hs Agonist 9.1 pEC50 5
pEC50 9.1 (EC50 8x10-10 M) [5]
AC261066 Hs Full agonist 7.9 – 8.1 pEC50 26
pEC50 7.9 – 8.1 [26]
tretinoin Hs Agonist 7.92 pEC50 5
pEC50 7.92 (EC50 1.2x10-8 M) [5]
AC55649 Hs Full agonist 6.5 – 7.3 pEC50 26
pEC50 6.5 – 7.3 [26]
BMS641 Hs Agonist 8.6 pIC50 12
pIC50 8.6 [12]
TTNPB Hs Agonist 8.0 pIC50 16-17,32,40
pIC50 8.0 [16-17,32,40]
Agonist Comments
All-trans-retinoic acid is the most potent endogenous retinoid. The existence of 9-cis retinoic acid as natural bioactive retinoid remains to be established. Synthetic compounds (reported above) are not metabolized by CYP26. BMS641 is a partial RARβ-selective agonist. However no fully RARβ-selective agonist has been reported so far.
Although tazarotene has high affinity for all retinoic acid receptor isoforms, it has roughly 5-8 times higher affinity for the β isoform [5].
Adapalene is selective for the β and γ RARs over the α isoform [4].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AGN193109 Hs Inverse agonist 8.7 pIC50 18-19,40
pIC50 8.7 [18-19,40]
BMS493 Hs Inverse agonist 8.54 pIC50 11
pIC50 8.54 [11]
Antagonist Comments
As yet no pure RARβ - selective antagonist has been reported so far. Both AGN193109 and BMS493 inverse agonists can induce corepressor association with RARβ instead of RARα.
DNA Binding
Structure:  Heterodimer, RXR partner
HRE core sequence:  5’-PuG(G/T)TCA
Response element:  DR5
DNA Binding Comments
Transient transfection using a reporter gene and EMSA have shown that RXR-RARβ heterodimers bind to a DR5 element.
Co-binding Partners
Name Interaction Effect Reference
AP1 Functional RARb inhibits AP-1 driven transactivation 33
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes A member of the p160 family 10,34
MED1 Co-activator No Yes Yes A member of the DRIP/TRAP/SMCC complex 23,30,36,47
NCOA3 Co-activator No Yes Yes A member of the p160 family 6,10,24
NCOA2 Co-activator No Yes Yes A member of the p160 family 11,22,41
Tissue Distribution
Brain, liver, kidney, heart, pituitary, colon, uterus, ovary, testis, prostate, adrenal, eye.
Expression level:  High
Species:  Human
Technique:  in situ hybridisation, Northern blot, Western blotting
References:  7-9,15,21,38-39
Tissue Distribution Comments
Similar distribution patterns are seen in the mouse and rat.
Physiological Consequences of Altering Gene Expression
RARβ null mutant : - abnormalities observed: growth retardation; behavorial defects; altered alveolar formation. - congenital defects observed: homeotic transformations and malformations of cervical vertebrae; persistence and hyperplasia of the primary vitreous body.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  13-14,20,27-28
Physiological Consequences of Altering Gene Expression Comments
Note that the specific RARβ1/β3 null mutants are apparently normal, and the specific RARβ2/β4 null mutants exhibited persistence and hyperplasia of the primary vitreous body.
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002191 abnormal artery morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002257 abnormal arytenoid cartilage morphology PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002884 abnormal branchial arch morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001310 abnormal conjunctiva morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010584 abnormal conotruncus septation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005300 abnormal corneal stroma morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002085 abnormal embryonic tissue morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000468 abnormal esophageal epithelium morphology PMID: 7607068 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0002912 abnormal excitatory postsynaptic potential PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0002912 abnormal excitatory postsynaptic potential PMID: 9883728 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005205 abnormal eye anterior chamber PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001286 abnormal eye development PMID: 16207763 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0008380 abnormal gonial bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001076 abnormal hypoglossal nerve morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006063 abnormal inferior vena cava morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005208 abnormal iris stroma morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002265 abnormal left major bronchus morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002840 abnormal lens fiber morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 16207763 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001175 abnormal lung morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008969 abnormal nasolacrimal duct morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0004054 abnormal periocular mesenchyme morphology PMID: 16207763 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0006069 abnormal retinal neuronal layer morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 16207763 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001325 abnormal retina morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002266 abnormal right major bronchus morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002698 abnormal sclera morphology PMID: 9240560 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 7607068 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001463 abnormal spatial learning PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001463 abnormal spatial learning PMID: 9883728 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005107 abnormal stapes morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000471 abnormal stomach epithelium morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003117 abnormal tracheal-esophageal septation PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000534 abnormal ureter morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001139 abnormal vagina morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002699 abnormal vitreous body PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000159 abnormal xiphoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001899 absent long term depression PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001899 absent long term depression PMID: 9883728 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001181 absent lungs PMID: 7607068 
Rarb+|Rarbtm1Mma Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008514 absent retinal inner plexiform layer PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004666 absent stapedial artery PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001304 cataracts PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010714 coloboma of the iris PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010716 coloboma of the optic disc PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001262 decreased body weight PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008972 ethmoturbinate hypoplasia PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003924 herniated diaphragm PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000519 hydronephrosis PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004616 lumbar vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97857  MP:0002169 no abnormal phenotype detected PMID: 7958449 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001289 persistence of hyaloid vascular system PMID: 9240560 
Rarbtm2.1Ipc Rarbtm2.1Ipc/Rarbtm2.1Ipc
involves: C57BL/6 * SJL
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 11857787 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 16207763 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0001732 postnatal growth retardation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 9240560 
Rarbtm1Vgi Rarbtm1Vgi/Rarbtm1Vgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:97857  MP:0001473 reduced long term potentiation PMID: 9883728 
Rarbtm1Vgi|Rxrbtm1Rev Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MGI:97857  MGI:98215  MP:0001473 reduced long term potentiation PMID: 9883728 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004158 right aortic arch PMID: 9240560 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009076 rudimentary Mullerian ducts PMID: 7607068 
Rarbtm1Mma|Rargtm4Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97857  MGI:97858  MP:0003604 single kidney PMID: 9376317 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010702 split cervical atlas PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010702 split cervical atlas PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004687 split vertebrae PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010402 ventricular septal defect PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Rarbtm1Mma Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97857  MP:0006200 vitreous body deposition PMID: 9240560 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Non-small-cell lung cancer
Role: 
References:  3,35,46
Mutations not determined
Disease:  Breast cancer
Role: 
References:  42-45
Mutations not determined
Disease:  Esophageal cancer
Role: 
References:  37
Mutations not determined
Disease:  Matthew-Wood syndrome
Orphanet:  2470
References: 
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  RARβ1: retinoic acid receptor, beta isoform 1. The b1 isoform differs from b2 in the A domain.
Amino acids:  448
Protein accession: 
References:  49
Type:  Splice variant
Species:  Human
Description:  RARβ2: retinoic acid receptor, beta isoform 2:- In contrast to the b1 isoform, b2 is transcribed from promoter (the downstream one, P2) that contains a DR5 and which is inducible by retinoid. The b2 isoform differs from b1 in the A domain.
Amino acids:  336
Protein accession: 
References:  49
Type:  Splice variant
Species:  Mouse
Description:  RARβ3:- b3 isoform is generated from the promoter P1 and differs from b1 isoform by its N-terminal part. It was not detected in human.
Amino acids:  448
Protein accession: 
References:  49
Type:  Splice variant
Species:  Human
Description:  RARβ4:- b4 isoform is generated from the promoter P2 and differs from b2 isoform by its N-terminal part that initiate in a non-AUG codon, CUG.
References:  31
General Comments
Using F9 RARβ2 null cells, some genes have been identified that require RARβ2 for their regulation by ATRA in F9 cells [25,50]. In contrast to RARα, unliganded RARβ poorly interacts with both NCoR and SMRT corepressors.

References

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2. Brand N, Petkovich M, Krust A, Chambon P, de Thé H, Marchio A, Tiollais P, Dejean A. (1988) Identification of a second human retinoic acid receptor. Nature332 (6167): 850-3. [PMID:2833708]

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4. Charpentier B, Bernardon JM, Eustache J, Millois C, Martin B, Michel S, Shroot B. (1995) Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J. Med. Chem.38 (26): 4993-5006. [PMID:8544175]

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6. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell90 (3): 569-80. [PMID:9267036]

7. de The H, Marchio A, Tiollais P, Dejean A. (1989) Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J.8 (2): 429-33. [PMID:2542014]

8. Dollé P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P. (1989) Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature342 (6250): 702-5. [PMID:2556642]

9. Dollé P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P. (1990) Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development110 (4): 1133-51. [PMID:1966045]

10. Farboud B, Hauksdottir H, Wu Y, Privalsky ML. (2003) Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol. Cell. Biol.23 (8): 2844-58. [PMID:12665583]

11. Germain P, Iyer J, Zechel C, Gronemeyer H. (2002) Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature415 (6868): 187-92. [PMID:11805839]

12. Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H. (2004) Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep.5 (9): 877-82. [PMID:15319780]

13. Ghyselinck NB, Dupé V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C, Chambon P, Mark M. (1997) Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int. J. Dev. Biol.41 (3): 425-47. [PMID:9240560]

14. Grondona JM, Kastner P, Gansmuller A, Décimo D, Chambon P, Mark M. (1996) Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Development122 (7): 2173-88. [PMID:8681798]

15. Haq R, Pfahl M, Chytil F. (1991) Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc. Natl. Acad. Sci. U.S.A.88 (18): 8272-6. [PMID:1654565]

16. Keidel S, LeMotte P, Apfel C. (1994) Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping. Mol. Cell. Biol.14 (1): 287-98. [PMID:8264595]

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How to cite this page

1B. Retinoic acid receptors: Retinoic acid receptor-β. Last modified on 02/05/2014. Accessed on 24/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=591.