Retinoic acid receptor-γ

Nomenclature: Retinoic acid receptor-γ

Systematic Nomenclature: NR1B3

Family: 1B. Retinoic acid receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 454 12q13 RARG retinoic acid receptor, gamma 29,36,46
Mouse 458 15F Rarg retinoic acid receptor, gamma 30,46
Rat 458 7q36 Rarg retinoic acid receptor, gamma 38,43,46
Previous and Unofficial Names
RARC
RARγ
NR1B3
LOC685072
Rarg
retinoic acid receptor, gamma
similar to Retinoic acid receptor gamma-A (RAR-gamma-A)
RAR gamma 2
RARgamma2
AI385767
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Retinoic acid receptor-γ (ligand-binding domain)- cocrystallised with agonist
PDB Id:  2LBD
Ligand:  tretinoin   This ligand is endogenous
Resolution:  2.06Å
Species:  Human
References:  51
Natural/Endogenous Ligands
tretinoin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
tretinoin Hs Agonist 9.6 pKd 1,31,33,48,61
pKd 9.6 [1,31,33,48,61]
alitretinoin Hs Agonist 9.0 pKd 33,48
pKd 9.0 [33,48]
CD666 Hs Agonist 7.17 pKd 4
pKd 7.17 [4]
AHPN Hs Agonist 7.11 pKi 7
pKi 7.11 (Ki 7.7x10-8 M) [7]
adapalene Hs Agonist 6.89 pKi 7
pKi 6.89 (Ki 1.3x10-7 M) [7]
Description: Binding affinity to RARγ using [3H]CD 367 as radioligand.
tretinoin Hs Agonist 9.7 pEC50 8
pEC50 9.7 (EC50 2x10-10 M) [8]
tazarotene Hs Agonist 7.4 pEC50 8
pEC50 7.4 (EC50 4x10-8 M) [8]
TTNPB Hs Agonist 7.82 pIC50 31,33
pIC50 7.82 [31,33]
BMS270394 Hs Agonist 6.3 pIC50 32-33
pIC50 6.3 [32-33]
Agonist Comments
Although all-trans-retinoic acid has high affinity for all retinoic acid receptor isoforms, it has approximately 6-8 times higher affinity for the γ isoform [8].
Adapalene is selective for the β and γ RARs over the α isoform [7].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AGN193109 Hs Antagonist 8.5 pIC50 34-35,61
pIC50 8.5 [34-35,61]
CD2665 Hs Antagonist 7.1 pIC50 59
pIC50 7.1 [59]
BMS493 Hs Antagonist 7.0 pIC50 22
pIC50 7.0 [22]
MM 11253 Hs Antagonist - - 39
[39]
Antagonist Comments
AGN193109 was the first described inverse agonist. CD2665 is a RARβ/γ antagonist. No pure RARγ-selective antagonist has been reported so far.
DNA Binding
Structure:  Heterodimer, RXR partner
HRE core sequence:  5’-PuG(G/T)TCA-3’
Response element:  DR2, DR5
DNA Binding Comments
The classical sequence is a 5-pb-spaced direct repeat (DR5). In DR5 and DR2 RXR occupies the 5’ element.
Co-binding Partners
Name Interaction Effect Reference
AP1 Functional RARg inhibits AP-1 driven transactivation 11,37,49,56-57
cdk7/TFIIH Physical, Functional TFIIH phosphorylates RARg2 in its A/B region (ser 68) by cdk7 subunit. 2,52
p38MAPK Functional p38MAPK is required for RA-induced RARg degradation and transactivation 24-25,52
SUG1 Physical, Functional SUG1 is required for RA-induced RARg degradation and transactivation 24-25,52
vinexin beta Physical, Functional Interacts with AF-1 domain of RARg and repress RARgamma-mediated transcription. 5
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOR1 Co-repressor No No No Binding of an agonist to RARg causes NCoR dissociation 18,28,47,66
NCOA1 Co-activator No Yes Yes A member of the p160 family 38,47,50
NCOA2 Co-activator No Yes Yes A member of the p160 family 47,63-64
NCOA3 Co-activator No Yes Yes A member of the p160 family 9,18,41
NCOR2 Co-repressor No No No Binding of an agonist to RARg causes SMRT dissociation 10,55-56
Main Target Genes
Name Species Effect Technique Comments References
RARβ2 Human Activated EMSA This gene has been shown to be activated in all species (human,mouse,rat). The promoter harbors a DR5 element 12-13,19
Hoxa1 Mouse Activated The promoter harbors a DR5 element 12,16,38
Rbp1 Mouse Activated The promoter harbors a DR2 element. 12,58
Crabp2 Mouse Activated EMSA The promoter harbors a DR2 element. 12,17
Lamb1-1 Mouse Activated EMSA The promoter harbors a DR5 element. 62
Tissue Distribution
Epidermis
Expression level:  High
Species:  Human
Technique:  Northern Blot, in situ hybridization, Western blotting
References:  14-15,26-27,30,36,54
Tissue Distribution Comments
The different RARγ isoforms exhibit specific expression patterns.
Functional Assays
Cellular differentiation assay
Species:  Mouse
Tissue:  F9 murine embryonal carcinoma cell line.
Response measured:  Primitive endodermal differentiation / morphological differentiation.
References:  12,53,62
Physiological Consequences of Altering Gene Expression
RARγ null mutant : - abnormalities observed: growth deficiency; male sterility; squamous epithelia of various epithelia; impaired alveolar formation. - congenital defects observed: webbed digits, homeotic transformations and malformations of cervical vertebrae, malformed laryngael cartilages and tracheal rings; agenesis of the Harderian glands; agenesis of the metoptic pillar of the skull; abnormal differentiation of granular keratinocytes.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  6,23,42,44-45
Physiological Consequences of Altering Gene Expression Comments
Note that specific RARγ2 null mutants are apparently normal, and specific RARγ a null mutant exhibited growth deficiency, malformations of cervical vertebrae and abnormal differentiation of granular keratinocytes.
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003235 abnormal alisphenoid bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003235 abnormal alisphenoid bone morphology PMID: 9376317 
Rargtm4Ipc|Rxratm2Ipc Rargtm4Ipc/Rargtm4Ipc,Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:97858  MGI:98214  MP:0005193 abnormal anterior eye segment morphology PMID: 9376317 
Rargtm2Ipc|Rxratm2Ipc Rargtm2Ipc/Rargtm2Ipc,Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97858  MGI:98214  MP:0005193 abnormal anterior eye segment morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002191 abnormal artery morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002257 abnormal arytenoid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002257 abnormal arytenoid cartilage morphology PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002114 abnormal axial skeleton morphology PMID: 8388780 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002114 abnormal axial skeleton morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002114 abnormal axial skeleton morphology PMID: 9376317 
Hoxd4tm1Bhr|Rargtm1Ipc Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
MGI:96208  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 10559481 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Rargtm4Ipc Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv
MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 9376317 
Hoxd4tm1Bhr|Rargtm1Ipc Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
MGI:96208  MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 10559481 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001310 abnormal conjunctiva morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005300 abnormal corneal stroma morphology PMID: 9240560 
Rargtm4Ipc Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv
MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Rarg+|Rargtm4Ipc Rargtm4Ipc/Rarg+
involves: 129/Sv
MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Rargtm3Ipc|Tg(KRT14-cre)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97858  MP:0001216 abnormal epidermal layer morphology PMID: 16751185 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rargtm3Ipc|Tg(CMV-cre/ERT)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(CMV-cre/ERT)1Ipc/0
involves: C57BL/6 * SJL
MGI:2446419  MGI:97858  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre/ERT2)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre/ERT2)1Ipc/0
Not Specified
MGI:2177423  MGI:97858  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97858  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005205 abnormal eye anterior chamber PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001286 abnormal eye development PMID: 16207763 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001340 abnormal eyelid morphology PMID: 8388780 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0005248 abnormal Harderian gland morphology PMID: 8388780 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0005248 abnormal Harderian gland morphology PMID: 7631783 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005248 abnormal Harderian gland morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003056 abnormal hyoid bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0005106 abnormal incus morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005106 abnormal incus morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005208 abnormal iris stroma morphology PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rargtm3Ipc|Tg(CMV-cre/ERT)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(CMV-cre/ERT)1Ipc/0
involves: C57BL/6 * SJL
MGI:2446419  MGI:97858  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre/ERT2)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre/ERT2)1Ipc/0
Not Specified
MGI:2177423  MGI:97858  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97858  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000527 abnormal kidney development PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0009608 abnormal lamellar body morphology PMID: 16751185 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002840 abnormal lens fiber morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 16207763 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001303 abnormal lens morphology PMID: 9240560 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003049 abnormal lumbar vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003049 abnormal lumbar vertebrae morphology PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008969 abnormal nasolacrimal duct morphology PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0009730 abnormal neural arch morphology PMID: 8388780 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0004054 abnormal periocular mesenchyme morphology PMID: 16207763 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001168 abnormal prostate gland epithelium morphology PMID: 8388780 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0001168 abnormal prostate gland epithelium morphology PMID: 7631783 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001158 abnormal prostate gland morphology PMID: 8388780 
Rargtm3.1Ipc Rargtm3.1Ipc/Rargtm3.1Ipc
involves: C57BL/6 * SJL
MGI:97858  MP:0001158 abnormal prostate gland morphology PMID: 11857788 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0003639 abnormal response to vitamins PMID: 8388780 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0006069 abnormal retinal neuronal layer morphology PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 16207763 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0001325 abnormal retina morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002698 abnormal sclera morphology PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002059 abnormal seminal vesicle morphology PMID: 8388780 
Rargtm3.1Ipc Rargtm3.1Ipc/Rargtm3.1Ipc
involves: C57BL/6 * SJL
MGI:97858  MP:0002059 abnormal seminal vesicle morphology PMID: 11857788 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0002059 abnormal seminal vesicle morphology PMID: 7631783 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002113 abnormal skeleton development PMID: 8388780 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rargtm3Ipc|Tg(CMV-cre/ERT)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(CMV-cre/ERT)1Ipc/0
involves: C57BL/6 * SJL
MGI:2446419  MGI:97858  MP:0002060 abnormal skin morphology PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre/ERT2)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre/ERT2)1Ipc/0
Not Specified
MGI:2177423  MGI:97858  MP:0002060 abnormal skin morphology PMID: 16751185 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004423 abnormal squamosal bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004423 abnormal squamosal bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004665 abnormal stapedial artery morphology PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000157 abnormal sternum morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003047 abnormal thoracic vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003047 abnormal thoracic vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000703 abnormal thymus morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000681 abnormal thyroid gland morphology PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0006032 abnormal ureteric bud morphology PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000534 abnormal ureter morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000516 abnormal urinary system morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0001120 abnormal uterus morphology PMID: 7607068 
Cdx1tm1Lhn|Rarg+|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004658 abnormal ventral tubercle of atlas PMID: 14660544 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Cdx1+|Cdx1tm1Pgr|Rargtm1Ipc Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 14660544 
Cdx1+|Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 14660544 
Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 14660544 
Cdx1tm1Lhn|Rarg+|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004599 abnormal vertebral arch morphology PMID: 14660544 
Rarg+|Rargtm1Ipc Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:97858  MP:0004601 abnormal vertebral spinous process PMID: 14660544 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:97858  MP:0004601 abnormal vertebral spinous process PMID: 14660544 
Cdx1+|Cdx1tm1Pgr|Rargtm1Ipc Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004601 abnormal vertebral spinous process PMID: 14660544 
Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004601 abnormal vertebral spinous process PMID: 14660544 
Cdx1tm1Lhn|Rarg+|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004601 abnormal vertebral spinous process PMID: 14660544 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002699 abnormal vitreous body PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008881 absent Harderian gland PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000520 absent kidney PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010705 absent metoptic pilar PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008514 absent retinal inner plexiform layer PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003642 absent seminal vesicle PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003722 absent ureter PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003558 absent uterus PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003557 absent vas deferens PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004620 cervical vertebral fusion PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004620 cervical vertebral fusion PMID: 9376317 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0004615 cervical vertebral transformation PMID: 8388780 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rarg+|Rargtm1Ipc Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Cdx1+|Cdx1tm1Pgr|Rargtm1Ipc Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Cdx1+|Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Cdx1tm1Lhn|Rarg+|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004615 cervical vertebral transformation PMID: 14660544 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010714 coloboma of the iris PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010716 coloboma of the optic disc PMID: 9240560 
Hoxd4tm1Bhr|Rargtm1Ipc Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
MGI:96208  MGI:97858  MP:0001265 decreased body size PMID: 10559481 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001262 decreased body weight PMID: 8388780 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0001262 decreased body weight PMID: 7631783 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 7631783 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0008770 decreased survivor rate PMID: 8388780 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000284 double outlet heart right ventricle PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002185 ectopia PMID: 7607068 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003007 ectopic thymus PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0008972 ethmoturbinate hypoplasia PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0004552 fused tracheal cartilage rings PMID: 8388780  9376317 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0004552 fused tracheal cartilage rings PMID: 7631783 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 8388780 
Hoxd4tm1Bhr|Rargtm1Ipc Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
MGI:96208  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 10559481 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0004613 fusion of vertebral arches PMID: 8388780 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 9240560 
Cdx1+|Cdx1tm1Pgr|Rargtm1Ipc Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 14660544 
Cdx1+|Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 14660544 
Cdx1tm1Lhn|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 14660544 
Cdx1tm1Lhn|Rarg+|Rargtm1Ipc Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
involves: 129 * C57BL/6
MGI:88360  MGI:97858  MP:0004613 fusion of vertebral arches PMID: 14660544 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0000519 hydronephrosis PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002796 impaired skin barrier function PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97858  MP:0002796 impaired skin barrier function PMID: 16751185 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001925 male infertility PMID: 8388780 
Hoxd4tm1Bhr|Rargtm1Ipc Hoxd4tm1Bhr/Hoxd4tm1Bhr,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1
MGI:96208  MGI:97858  MP:0001925 male infertility PMID: 10559481 
Rargtm3.1Ipc Rargtm3.1Ipc/Rargtm3.1Ipc
involves: C57BL/6 * SJL
MGI:97858  MP:0001925 male infertility PMID: 11857788 
Rarg+|Rargtm1Ipc Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0005287 narrow eye opening PMID: 9240560 
Rargtm2Ipc Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002169 no abnormal phenotype detected PMID: 8388780 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Rarbtm1Ipc|Rargtm1Ipc Rarbtm1Ipc/Rarbtm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 9376317 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0002081 perinatal lethality PMID: 9240560 
Rarbtm2Ipc|Rargtm3Ipc|Tg(Wnt1-cre)11Rth Rarbtm2Ipc/Rarbtm2Ipc,Rargtm3Ipc/Rargtm3Ipc,Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * SJL
MGI:2447280  MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 16207763 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarb+|Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002633 persistent truncus arteriosis PMID: 9376317 
Rargtm4Ipc Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv
MGI:97858  MP:0001732 postnatal growth retardation PMID: 9376317 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001732 postnatal growth retardation PMID: 8388780 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0002083 premature death PMID: 8388780 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0002083 premature death PMID: 7631783 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002080 prenatal lethality PMID: 7607068 
Rargtm1Blt Rargtm1Blt/Rargtm1Blt
involves: 129P2/OlaHsd * C57BL/6J
MGI:97858  MP:0001922 reduced male fertility PMID: 7631783 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 9376317 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0000154 rib fusion PMID: 8388780 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004158 right aortic arch PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004158 right aortic arch PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009076 rudimentary Mullerian ducts PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009075 rudimentary Wolffian ducts PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0001196 shiny skin PMID: 16751185 
Rargtm3Ipc|Tg(KRT14-cre)1Ipc Rargtm3Ipc/Rargtm3Ipc,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97858  MP:0001196 shiny skin PMID: 16751185 
Rarbtm1Mma|Rargtm4Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97857  MGI:97858  MP:0003604 single kidney PMID: 9376317 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0010702 split cervical atlas PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rarbtm1Mma|Rarg+|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rarg+
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0010703 split cervical axis PMID: 9240560 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 8388780 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0010502 ventricle myocardium hypoplasia PMID: 7607068 
Rargtm1Ipc Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97858  MP:0003036 vertebral transformation PMID: 8388780 
Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarbtm1Mma,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Rarb+|Rarbtm1Mma|Rargtm1Ipc Rarbtm1Mma/Rarb+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97857  MGI:97858  MP:0003036 vertebral transformation PMID: 9240560 
Gene Expression and Pathophysiology
Level of RARγ is reduced after UV treatment of human skin.
Tissue or cell type:  epidermis
Pathophysiology:  photoaging
Species:  Human
Technique: 
References:  20-21,65
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  RAR&gama;1:- isoform differs from RARg2 isoform by its N-terminal domain.
Amino acids:  454
Protein accession: 
References:  30,40
Type:  Splice variant
Species:  Human
Description:  RARγ2:- The expression of this isoform is regulated through a specific RARE element. RARg2 is phosphorylated by p38MAPK (ser66) and by cdk7/TFIIH (ser68)
Amino acids:  443
Protein accession: 
References:  2-3,24-26,30,40,60

References

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1B. Retinoic acid receptors: Retinoic acid receptor-γ. Last modified on 02/05/2014. Accessed on 20/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=592.