Retinoid X receptor-α

Nomenclature: Retinoid X receptor-α

Systematic Nomenclature: NR2B1

Family: 2B. Retinoid X receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 462 9q34.3 RXRA retinoid X receptor, alpha 2,31,47
Mouse 467 2 17.0 cM Rxra retinoid X receptor alpha 30,42-43,46
Rat 467 3p12 Rxra retinoid X receptor alpha 25
Previous and Unofficial Names
RXRα
NR2B1
nuclear receptor subfamily 2 group B member 1
retinoic acid receptor RXR-alpha
retinoid X receptor alpha
RXR alpha 1
RXRalpha1
9530071D11Rik
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  RXR retinoid X receptor-ligand binding domain
PDB Id:  1MZN
Ligand:  SR11237
Resolution:  1.9Å
Species:  Human
References:  22
Natural/Endogenous Ligands
alitretinoin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AGN194204 Hs Agonist 9.4 pIC50 67
pIC50 9.4 [67]
LG100268 Hs Agonist 8.5 pIC50 7,38,63
pIC50 8.5 [7,38,63]
CD3254 N/A Agonist 8.5 pIC50 26
pIC50 8.5 [26]
alitretinoin Hs Agonist 7.1 – 8.2 pIC50 1,29,38,45-46,53
pIC50 7.1 – 8.2 [1,29,38,45-46,53]
bexarotene Hs Agonist 7.4 pIC50 8,10,63
pIC50 7.4 [8,10,63]
methoprene acid Hs Agonist 5.7 pIC50 28
pIC50 5.7 [28]
phytanic acid Mm Agonist - - 39,44
[39,44]
SR11237 Hs Agonist - - 40
[40]
docosahexaenoic acid Mm Agonist - - 20,39
[20,39]
View species-specific agonist tables
Agonist Comments
It is unclear whether docosahexaenoic acid and phytanic acid are bona fide endogenous ligands for RXR.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
LG100754 Hs Antagonist 8.5 pIC50 11
pIC50 8.5 [11]
PA451 Hs Antagonist - - 61
[61]
UVI3003 Mm Antagonist - - 56
[56]
View species-specific antagonist tables
Antagonist Comments
NB: LG100754 is a RXR:RXR antagonist, a RXR:PPARalpha agonist but also functions as a RXR:PPARgamma agonist [11].
DNA Binding
Structure:  Homodimer, Heterodimer, RXR partner
HRE core sequence:  5’-AGGTCA
Response element:  DR1, DR2, DR3, DR4, DR5
DNA Binding Comments
RXR can bind to several DR elements as common heterodimerization patners for members of the subfamily 1 of nuclear receptors. In direct repeats, RXR generally occupies the 5’-element. RXR can also form RXR-RXR homodimers that bind to DR1.
Co-binding Partners
Name Interaction Effect Reference
Thyroid hormone receptor-α Physical, Functional DNA binding (this is also true for TRβ) 9,27,43
Vitamin D receptor Physical, Functional DNA binding 9,27
Retinoic acid receptor-α Physical, Functional DNA binding (also all the other RARs) 4,9,26-27,37,43,71
Peroxisome proliferator-activated receptor-α Physical, Functional DNA binding 37,64
Liver X receptor-α Physical, Functional DNA binding (and also all other LXRs) 23,62,68-69
Farnesoid X receptor Physical, Functional DNA binding 58
Pregnane X receptor Physical, Functional DNA binding 5-6,36,41
Constitutive androstane receptor Physical, Functional DNA binding 3,17
Nuclear receptor related 1 Physical, Functional DNA binding 55
Nerve Growth factor IB Physical, Functional DNA binding 24,55
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes 51,54
NCOA2 Co-activator No Yes Yes 65-66
NCOA3 Co-activator No Yes - 15,51
PPARGC1A Co-activator No Yes Yes 19
MED1 Co-activator No Yes Yes 51,70
TBP Co-activator No Yes Yes 38,51,57
TAF4 Co-activator No Yes Yes 38,51,57
TAF11 Co-activator No Yes Yes 50
CREBBP Co-activator No Yes Yes 12,32
EP300 Co-activator No Yes Yes 12
Tissue Distribution
Liver, lung, muscle, kidney, epidermis, intestine, skin
Expression level:  High
Species:  Human
Technique:  Northern, in situ, Western, other
References:  21,46-47
Tissue Distribution Comments
RXRa2, an isoform, is specifically expressed in testis. Similar expression patterns are also seen in rodents.
Functional Assays
Cellular differentiation
Species:  Mouse
Tissue:  fibroblasts - embryo - (3T3-L1 pre-adipocytes)
Response measured:  3T3-L1 cells are differentiated to adipocytes. The extend of the differentiation is quantitated by measuring the accumulation of triglyceride produce within the cytoplasm of the adipocyte.
References:  10,13-14
Induction of apoptosis (associated to RARa activation)
Species:  Human
Tissue:  Leukemia cell lines (HL60 or PLB-985)
Response measured:  Apoptosis (typical apoptotic morphological features, genomic DNA laddering, TUNEL assay).
References:  52-53
Cellular differentiation assay (Synergy with RARg activation).
Species:  Mouse
Tissue:  F9 murine embryonal carcinoma cell line.
Response measured:  Primitive endodermal differentiation : morphological differentiation.
References:  16,18
Physiological Consequences of Altering Gene Expression
Null mice: The major defect is an hypoplasia of the myocardium that appears to be the principal cause of animal death that occurs by cardiac failure arround E14.5 and ocular malformation has been observed.
Species:  Mouse
Tissue: 
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  19,33-35,48-49,59-60
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Rargtm4Ipc|Rxratm2Ipc Rargtm4Ipc/Rargtm4Ipc,Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:97858  MGI:98214  MP:0005193 abnormal anterior eye segment morphology PMID: 9376317 
Rargtm2Ipc|Rxratm2Ipc Rargtm2Ipc/Rargtm2Ipc,Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97858  MGI:98214  MP:0005193 abnormal anterior eye segment morphology PMID: 9376317 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000297 abnormal atrioventricular cushion morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002745 abnormal atrioventricular valve morphology PMID: 8823298 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002114 abnormal axial skeleton morphology PMID: 11493527 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0002672 abnormal branchial arch artery morphology PMID: 19255444 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002127 abnormal cardiovascular system morphology PMID: 11493527 
Rxratm2Ipc Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:98214  MP:0002127 abnormal cardiovascular system morphology PMID: 7923367 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0004022 abnormal cone electrophysiology PMID: 14742273 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010585 abnormal conotruncal ridge morphology PMID: 8823298 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0010584 abnormal conotruncus septation PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0010584 abnormal conotruncus septation PMID: 19255444 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0005300 abnormal corneal stroma morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0005300 abnormal corneal stroma morphology PMID: 19255444 
Rxratm2Ipc Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:98214  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0002376 abnormal dendritic cell physiology PMID: 16259011 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002110 abnormal digit morphology PMID: 11493527 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm1Ipc Rxratm1Ipc/Rxratm1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 16751185 
Rxratm2Ipc Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:98214  MP:0002086 abnormal extraembryonic tissue morphology PMID: 9356169 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001286 abnormal eye development PMID: 19255444 
Rxratm1Ipc|Rxratm2Ipc Rxratm1Ipc/Rxratm2Ipc
involves: 129S2/SvPas * C57BL/6
MGI:98214  MP:0001286 abnormal eye development PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001286 abnormal eye development PMID: 19255444 
Rxratm2Ipc|Rxratm4.1Ipc Rxratm2Ipc/Rxratm4.1Ipc
involves: 129/Sv
MGI:98214  MP:0001286 abnormal eye development PMID: 11171393 
Rxratm4.1Ipc Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0001286 abnormal eye development PMID: 11171393 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001340 abnormal eyelid morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001340 abnormal eyelid morphology PMID: 19255444 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002092 abnormal eye morphology PMID: 11493527 
Rxratm2Ipc Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:98214  MP:0002092 abnormal eye morphology PMID: 7923367 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0008858 abnormal hair cycle anagen phase PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0008860 abnormal hair cycle telogen phase PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0009555 abnormal hair follicle melanin granule distribution PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000377 abnormal hair follicle morphology PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0002073 abnormal hair growth PMID: 11171393 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000267 abnormal heart development PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0003923 abnormal heart left atrium morphology PMID: 7638202 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000266 abnormal heart morphology PMID: 7638202 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005294 abnormal heart ventricle morphology PMID: 7638202  7926783 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005294 abnormal heart ventricle morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000281 abnormal interventricular septum morphology PMID: 8823298 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm1Ipc Rxratm1Ipc/Rxratm1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0008117 abnormal Langerhans cell morphology PMID: 11171393 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001303 abnormal lens morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001303 abnormal lens morphology PMID: 19255444 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002339 abnormal lymph node morphology PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0005075 abnormal melanosome morphology PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000286 abnormal mitral valve morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000286 abnormal mitral valve morphology PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002189 abnormal myocardial trabeculae morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002189 abnormal myocardial trabeculae morphology PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0004056 abnormal myocardium compact layer morphology PMID: 7926783 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0004056 abnormal myocardium compact layer morphology PMID: 8823298 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0004056 abnormal myocardium compact layer morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0004056 abnormal myocardium compact layer morphology PMID: 19255444 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005329 abnormal myocardium layer morphology PMID: 7926783  8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005329 abnormal myocardium layer morphology PMID: 8823298 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0002864 abnormal ocular fundus morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0002864 abnormal ocular fundus morphology PMID: 19255444 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0008259 abnormal optic disc morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0008259 abnormal optic disc morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006030 abnormal otic vesicle development PMID: 19255444 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000288 abnormal pericardium morphology PMID: 7926783 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0003729 abnormal photoreceptor outer segment morphology PMID: 14742273 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001716 abnormal placenta labyrinth morphology PMID: 19255444 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001711 abnormal placenta morphology PMID: 19255444 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002089 abnormal postnatal growth/weight/body size PMID: 11493527 
Rxra+|Rxratm2Ipc Rxratm2Ipc/Rxra+
involves: 129/Sv
MGI:98214  MP:0002089 abnormal postnatal growth/weight/body size PMID: 7923367 
Rxra+|Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxra+,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0009736 abnormal prostate gland branching morphogenesis PMID: 12183441 
Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0009736 abnormal prostate gland branching morphogenesis PMID: 12183441 
Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0003607 abnormal prostate gland physiology PMID: 12183441 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0004946 abnormal regulatory T cell physiology PMID: 16259011 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0003731 abnormal retinal outer nuclear layer morphology PMID: 14742273 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0005103 abnormal retinal pigmentation PMID: 14742273 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 14742273 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0001325 abnormal retina morphology PMID: 19255444 
Rxratm1Ipc|Rxrbtm1Mma Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:98214  MGI:98215  MP:0001325 abnormal retina morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0000933 abnormal rhombomere morphology PMID: 19255444 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0004021 abnormal rod electrophysiology PMID: 14742273 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0002698 abnormal sclera morphology PMID: 19255444 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002113 abnormal skeleton development PMID: 11493527 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001191 abnormal skin condition PMID: 16751185 
Rxratm1Ipc Rxratm1Ipc/Rxratm1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0001191 abnormal skin condition PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002060 abnormal skin morphology PMID: 16751185 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0002060 abnormal skin morphology PMID: 16751185 
Rxratm1Ipc Rxratm1Ipc/Rxratm1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0002060 abnormal skin morphology PMID: 16751185 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0002060 abnormal skin morphology PMID: 11171393 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0009527 abnormal sublingual duct morphology PMID: 19255444 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0002434 abnormal T-helper 2 cell morphology PMID: 16259011 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006356 abnormal third branchial arch artery morphology PMID: 19255444 
Rxratm2Ipc|Rxrbtm1Mma Rxratm2Ipc/Rxratm2Ipc,Rxrbtm1Mma/Rxrbtm1Mma
involves: 129/Sv * C57BL/6
MGI:98214  MGI:98215  MP:0006339 abnormal third branchial arch morphology PMID: 19255444 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002624 abnormal tricuspid valve morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002624 abnormal tricuspid valve morphology PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010454 abnormal truncus arteriosis septation PMID: 7926783 
Rxratm2Ipc|Rxratm4.1Ipc Rxratm2Ipc/Rxratm4.1Ipc
involves: 129/Sv
MGI:98214  MP:0001622 abnormal vasculogenesis PMID: 11171393 
Rxratm4.1Ipc Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0001622 abnormal vasculogenesis PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0004058 abnormal ventricle papillary muscle morphology PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0004058 abnormal ventricle papillary muscle morphology PMID: 8823298 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0008881 absent Harderian gland PMID: 19255444 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0000414 alopecia PMID: 16259011 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000414 alopecia PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000414 alopecia PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000414 alopecia PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010455 aortopulmonary window PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010519 atrioventricular block PMID: 7638202 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010413 complete atrioventricular septal defect PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0006138 congestive heart failure PMID: 7638202  7926783 
Rxratm1.1Krc Rxratm1.1Krc/Rxratm1.1Krc
involves: 129S4/SvJae * Black Swiss
MGI:98214  MP:0006138 congestive heart failure PMID: 9550726 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0001314 corneal opacity PMID: 16259011 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0003393 decreased cardiac output PMID: 7638202 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0003983 decreased cholesterol level PMID: 16751185 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0004200 decreased fetal size PMID: 19255444 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005333 decreased heart rate PMID: 7638202 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0004001 decreased hepatocyte proliferation PMID: 7926783 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0001327 decreased retinal photoreceptor cell number PMID: 14742273 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0005598 decreased ventricle muscle contractility PMID: 7638202 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0003011 delayed dark adaptation PMID: 14742273 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000422 delayed hair appearance PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000597 delayed hepatic development PMID: 7926783 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0001247 dermal cysts PMID: 16259011 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001247 dermal cysts PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001247 dermal cysts PMID: 11171393 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0004971 dermal hyperplasia PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001194 dermatitis PMID: 16199515 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0003140 dilated heart atrium PMID: 7926783 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002754 dilated heart right ventricle PMID: 7926783 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0000371 diluted coat color PMID: 16259011 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000371 diluted coat color PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000389 disorganized outer root sheath cells PMID: 11171393 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0008586 disorganized photoreceptor outer segment PMID: 14742273 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0000384 distorted hair follicle pattern PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000284 double outlet heart right ventricle PMID: 8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000284 double outlet heart right ventricle PMID: 8823298 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003853 dry skin PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001849 ear inflammation PMID: 16199515 
Rxratm2Ipc|Rxratm4.1Ipc Rxratm2Ipc/Rxratm4.1Ipc
involves: 129/Sv
MGI:98214  MP:0001785 edema PMID: 11171393 
Rxratm4.1Ipc Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0001785 edema PMID: 11171393 
Rxratm1.1Pcn|Rxrbtm1Ipc Rxratm1.1Pcn/Rxratm1.1Pcn,Rxrbtm1Ipc/Rxrbtm1Ipc
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MGI:98215  MP:0003984 embryonic growth retardation PMID: 19255444 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000599 enlarged liver PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000702 enlarged lymph nodes PMID: 16199515 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000291 enlarged pericardium PMID: 7926783 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000691 enlarged spleen PMID: 16199515 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001222 epidermal hyperplasia PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001222 epidermal hyperplasia PMID: 16199515 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000299 failure of atrioventricular cushion closure PMID: 8823298 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003413 hair follicle degeneration PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0003413 hair follicle degeneration PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0003413 hair follicle degeneration PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010559 heart block PMID: 7638202 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001242 hyperkeratosis PMID: 11171393 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0002461 increased immunoglobulin level PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0009583 increased keratinocyte proliferation PMID: 11171393 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0000218 increased leukocyte cell number PMID: 16199515 
Rxrapke Rxrapke/Rxrapke
C57BL/6J-Rxra
MGI:98214  MP:0000160 kyphosis PMID: 16259011 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0006208 lethality throughout fetal growth and development PMID: 7926783 
Rxratm1.1Krc Rxratm1.1Krc/Rxratm1.1Krc
involves: 129S4/SvJae * Black Swiss
MGI:98214  MP:0006208 lethality throughout fetal growth and development PMID: 9550726 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0006208 lethality throughout fetal growth and development PMID: 19255444 
Rxratm2Ipc|Rxratm4.1Ipc Rxratm2Ipc/Rxratm4.1Ipc
involves: 129/Sv
MGI:98214  MP:0006208 lethality throughout fetal growth and development PMID: 11171393 
Rxratm4.1Ipc Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0006208 lethality throughout fetal growth and development PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0006119 mitral valve atresia PMID: 7926783 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0006122 mitral valve stenosis PMID: 8823298 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001246 mixed cellular infiltration to dermis PMID: 16199515 
Rxratm1Ipc|Rxratm4Ipc|Rxrbtm1Mma|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001246 mixed cellular infiltration to dermis PMID: 16199515 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010420 muscular ventricular septal defect PMID: 7638202  7926783  8823298 
Myl2+|Myl2tm1(cre)Krc|Rxratm1Krc Myl2tm1(cre)Krc/Myl2+,Rxratm1Krc/Rxratm1Krc
involves: 129S4/SvJae * Black Swiss
MGI:97272  MGI:98214  MP:0002169 no abnormal phenotype detected PMID: 9550726 
Rxratm2Ipc|Rxratm4.1Ipc Rxratm2Ipc/Rxratm4.1Ipc
involves: 129/Sv
MGI:98214  MP:0003717 pallor PMID: 11171393 
Rxratm4.1Ipc Rxratm4.1Ipc/Rxratm4.1Ipc
involves: 129S2/SvPas
MGI:98214  MP:0003717 pallor PMID: 11171393 
Rxratm1.1Pcn Rxratm1.1Pcn/Rxratm1.1Pcn
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:98214  MP:0002081 perinatal lethality PMID: 19255444 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0002633 persistent truncus arteriosis PMID: 8823298 
Rxratm3Ipc Rxratm3Ipc/Rxratm3Ipc
involves: 129/Sv * C57BL/6
MGI:98214  MP:0002082 postnatal lethality PMID: 11493527 
Rxratm2Ipc Rxratm2Ipc/Rxratm2Ipc
involves: 129/Sv
MGI:98214  MP:0002080 prenatal lethality PMID: 7923367 
Rxra+|Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxra+,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0001167 prostate gland epithelial hyperplasia PMID: 12183441 
Rxra+|Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxra+,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0009219 prostate intraepithelial neoplasia PMID: 12183441 
Rxratm1Krc|Tg(Pbsn-cre)4Prb Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
MGI:2388169  MGI:98214  MP:0009219 prostate intraepithelial neoplasia PMID: 12183441 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010457 pulmonary artery stenosis PMID: 8823298 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0005548 retinal pigment epithelium atrophy PMID: 14742273 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001192 scaly skin PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001192 scaly skin PMID: 11171393 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MGI:98215  MP:0001196 shiny skin PMID: 16751185 
Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001196 shiny skin PMID: 16751185 
Rxratm4Ipc|Tg(Tyrp1-cre)1Ipc Rxratm4Ipc/Rxratm4Ipc,Tg(Tyrp1-cre)1Ipc/0
involves: 129S2/SvPas
MGI:2447649  MGI:98214  MP:0008587 short photoreceptor outer segment PMID: 14742273 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0001786 skin edema PMID: 7926783 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0004947 skin inflammation PMID: 11171393 
Rxratm4Ipc|Rxrbtm1Pcn|Tg(KRT14-cre/ERT2)1Ipc Rxratm4Ipc/Rxratm4Ipc,Rxrbtm1Pcn/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129S2/SvPas
MGI:2177423  MGI:98214  MGI:98215  MP:0001212 skin lesions PMID: 16199515 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001212 skin lesions PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000601 small liver PMID: 7926783 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0001245 thick dermal layer PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0009612 thick epidermis suprabasal layer PMID: 11171393 
Rxratm2Ipc|Rxratm4Ipc|Tg(KRT14-cre)1Ipc Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
involves: 129S2/SvPas * C57BL/6 * SJL
MGI:2177412  MGI:98214  MP:0004126 thin hypodermis PMID: 11171393 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000280 thin ventricular wall PMID: 7926783  8823298 
Rxra+|Rxratm1Rev Rxratm1Rev/Rxra+
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000280 thin ventricular wall PMID: 8823298 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000295 trabecula carnea hypoplasia PMID: 7926783 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0001201 translucent skin PMID: 7926783 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0000279 ventricular hypoplasia PMID: 7926783 
Rxratm1Rev Rxratm1Rev/Rxratm1Rev
involves: 129S4/SvJae * C57BL/6
MGI:98214  MP:0010640 ventricular myocardium compact layer hypoplasia PMID: 8823298 
General Comments
Through its heterodimeric interaction with many other nuclear receptors, RXRα may play a role in a wide variety of diseases as well as in the control of multiple target genes.

References

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2B. Retinoid X receptors: Retinoid X receptor-α. Last modified on 01/05/2014. Accessed on 29/07/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=610.