Liver receptor homolog-1

Nomenclature: Liver receptor homolog-1

Systematic Nomenclature: NR5A2

Family: 5A. Fushi tarazu F1-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 541 1q32.1 NR5A2 nuclear receptor subfamily 5, group A, member 2 8
Mouse 560 1 78.0cM Nr5a2 nuclear receptor subfamily 5, group A, member 2 19
Rat 560 13q13 Nr5a2 nuclear receptor subfamily 5, group A, member 2 9
Previous and Unofficial Names
FTZ-F1β
hB1F
FTZ-F1
hB1F-2
B1F2
LRH-1
Liver receptor homologue 1
α1-fetoprotein transcription factor
hepatocytic transcription factor
B1-binding factor
CYP7A promoter-binding factor
FTF
FTZ-F1beta
liver receptor homolog-1
FTZ-F1 beta
FTZ-F1 beta2 protein
fetoprotein transcription factor
liver receptor homolog 1
nuclear receptor subfamily 5 group A member 2
nuclear receptor subfamily 5, group A, member 2
D1Ertd308e
AU020803
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  LRH-1 Ligand Binding Domain
PDB Id:  1PK5
Resolution:  2.4Å
Species:  Human
References:  23
Natural/Endogenous Ligands
Comments: Orphan
DNA Binding
Structure:  Monomer
HRE core sequence:  YCA AGG YCR
Response element:  Half site
DNA Binding Comments
In the NR5A subfamily, specificity of DNA binding is dictated by the Ftz-F1 box, which is a stretch of 26 amino acids at the C terminus of the DBD.
Co-binding Partners
Name Interaction Effect Reference
DAX1 Physical, Functional Inhibition of LRH-1 dependent transactivation. 23
SHP Physical, Functional Inhibition of LRH-1 dependent transactivation. 15,23
Beta catenin Physical, Functional DNA binding and LRH-1 interacts with the armadillo repeats of beta-catenin. Beta catenin:LRH-1 complex formation enhance LRH-1 dependent transcriptional activation of the Cyclin E1 gene and beta catenin dependent activation of the Cyclin D1 gene. 2
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No No Yes 30
NCOA3 Co-activator No No Yes 18
EP300 Co-activator No No Yes 29
EID1 Co-activator No No No MBF-1 interacts with the Ftz-F1 box of LRH-1 and not with the AF-2. MBF-1 does not possess any of the classical histone modifying activities such as histone acetyl- or methyl transferase activities, linked to chromatin remodeling, but interacts in vitro with the transcription factor IID complex 3
PROX1 Co-repressor No No No Prox1 interacts with both the ligand binding domain (LBD) and the DNA binding domain (DBD) of hLRH-1. Gel shift assays reveal that Prox1 impairs the binding of hLRH-1 to the promoter of human cyp7a1 gene 21,27
SNW1 Co-activator No No No NCOA62 interacts and selectively activates LRH-1 in cell transfections assays. The SNW domain is required. (personal expert communication)
Main Target Genes
Name Species Effect Technique Comments References
CYP11A1 Human Activated Transient transfection, EMSA 11
APOA1 Human Activated ChIP, Transient transfection, EMSA, Other Activation of Apolipoprotein A-1 was shown in all species examined 5
Ccne1 Mouse Activated 2
STAR Human Activated Transient transfection, EMSA shown in all species 12
ABCG5 Human Activated Transient transfection, EMSA, Other LRH-1 activates the ABCG5/ABCG8 intergenic promoter 7
ABCG8 Human Activated Transient transfection, EMSA, Other LRH-1 activates the ABCG5/ABCG8 intergenic promoter 7
Tissue Distribution
Adult mammal tissues (endodermal; liver, pancreas, intestine) and species-specific in (pre-adipocyte ovarial, placenta, adrenal and testis)
Species:  Human
Technique:  Northern, in situ, Western, immunohistology
References:  1,4,6,8,10,14,16,24,26,28
Physiological Consequences of Altering Gene Expression
LRH-1 Knock-out Mice: LRH-1 -/- embryos die at E6.5–7.5, with features typical of visceral endoderm dysfunction. LRH-1 +/- adult mice are hypocholesterolemic, and express liver FTF at about 40% of the normal level. Haplo insufficiency of LRH-1 blunts intestinal tumorigenesis in the ApcMin/+ mice, a genetic model of intestinal cancer. Lrh-1+/- mice are protected against the formation of aberrant crypt foci in the colon of mice exposed to the carcinogen azoxymethane.
Species:  Mouse
Tissue: 
Technique:  Knockout
References:  2,20,25
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0005029 abnormal amnion morphology PMID: 15014077 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0005029 abnormal amnion morphology PMID: 15831456 
Nr5a2tm1Sakl|Tg(Alb-cre)21Mgn Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Alb-cre)21Mgn/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
MGI:1346834  MGI:2176226  MP:0004773 abnormal bile composition PMID: 18323469 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0004774 abnormal bile salt level PMID: 14766742 
Alb+|Albtm1(cre/ERT2)Mtz|Nr5a2tm2Sjns Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm2Sjns/Nr5a2tm2Sjns
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MGI:1346834  MGI:87991  MP:0004774 abnormal bile salt level PMID: 17908794 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd
MGI:1346834  MP:0000495 abnormal colon morphology PMID: 17670946 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd * C57BL/6J
MGI:1346834  MP:0000490 abnormal crypts of Lieberkuhn morphology PMID: 15327767 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd
MGI:1346834  MP:0000490 abnormal crypts of Lieberkuhn morphology PMID: 17670946 
Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0001675 abnormal ectoderm development PMID: 15014077 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0001675 abnormal ectoderm development PMID: 15831456 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0001672 abnormal embryogenesis/ development PMID: 15831456 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0001685 abnormal endoderm development PMID: 15831456 
Alb+|Albtm1(cre/ERT2)Mtz|Nr5a2tm2Sjns Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm2Sjns/Nr5a2tm2Sjns
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MGI:1346834  MGI:87991  MP:0003868 abnormal feces composition PMID: 17908794 
Alb+|Albtm1(cre/ERT2)Mtz|Nr5a2tm2Sjns Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm2Sjns/Nr5a2tm2Sjns
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MGI:1346834  MGI:87991  MP:0005342 abnormal lipid absorption PMID: 17908794 
Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0001680 abnormal mesoderm development PMID: 15014077 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0009661 abnormal pregnancy PMID: 17409375 
Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0001674 abnormal triploblastic development PMID: 15014077 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd
MGI:1346834  MP:0001652 colonic necrosis PMID: 17670946 
Nr5a2tm1Sjns|Tg(Vil-cre/ERT2)23Syr Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
involves: 129/Sv * C57BL/6 * DBA/2 * SJL
MGI:1346834  MGI:3053810  MP:0001652 colonic necrosis PMID: 17670946 
Nr5a2tm1Sakl|Tg(Alb-cre)21Mgn Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Alb-cre)21Mgn/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
MGI:1346834  MGI:2176226  MP:0005632 decreased circulating aspartate transaminase level PMID: 18323469 
Nr5a2tm1Sakl|Tg(Vil-cre)997Gum Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil-cre)997Gum/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL
MGI:1346834  MGI:2446957  MP:0005632 decreased circulating aspartate transaminase level PMID: 18323469 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0005179 decreased circulating cholesterol level PMID: 15014077 
Nr5a2tm1Sakl|Tg(Alb-cre)21Mgn Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Alb-cre)21Mgn/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
MGI:1346834  MGI:2176226  MP:0005179 decreased circulating cholesterol level PMID: 18323469 
Nr5a2tm1Sakl|Tg(Vil-cre)997Gum Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil-cre)997Gum/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL
MGI:1346834  MGI:2446957  MP:0005179 decreased circulating cholesterol level PMID: 18323469 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0005185 decreased circulating progesterone level PMID: 17409375 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: C57BL/6J
MGI:1346834  MP:0002780 decreased circulating testosterone level PMID: 17289919 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0001698 decreased embryo size PMID: 15831456 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: C57BL/6J
MGI:1346834  MP:0004929 decreased epididymis weight PMID: 17289919 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: C57BL/6J
MGI:1346834  MP:0004910 decreased seminal vesicle weight PMID: 17289919 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd
MGI:1346834  MP:0001785 edema PMID: 17670946 
Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0006205 embryonic lethality before somite formation PMID: 15014077 
Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129
MGI:1346834  MP:0006207 embryonic lethality during organogenesis PMID: 15831456 
Alb+|Albtm1(cre/ERT2)Mtz|Nr5a2tm2Sjns Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm2Sjns/Nr5a2tm2Sjns
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
MGI:1346834  MGI:87991  MP:0004789 increased bile salt level PMID: 17908794 
Nr5a2+|Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd
MGI:1346834  MP:0008537 increased susceptibility to induced colitis PMID: 17670946 
Nr5a2tm1Sjns|Tg(Vil-cre/ERT2)23Syr Nr5a2tm1Sjns/Nr5a2tm1Sjns,Tg(Vil-cre/ERT2)23Syr/?
involves: 129/Sv * C57BL/6 * DBA/2 * SJL
MGI:1346834  MGI:3053810  MP:0008537 increased susceptibility to induced colitis PMID: 17670946 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0004904 increased uterus weight PMID: 17409375 
Nr5a2tm1Auw Nr5a2tm1Auw/Nr5a2tm1Auw
involves: 129P2/OlaHsd * C57BL/6J
MGI:1346834  MP:0002080 prenatal lethality PMID: 15327767 
Nr5a2+|Nr5a2tm1Lex Nr5a2tm1Lex/Nr5a2+
involves: 129
MGI:1346834  MP:0002080 prenatal lethality PMID: 15831456 
Nr5a2+|Nr5a2tm1Bel Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL
MGI:1346834  MP:0001923 reduced female fertility PMID: 17409375 
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  LRH-1v1: identical to the most abundant isoform of LRH-1 with a larger A/B domain
Amino acids:  541
Protein accession: 
References:  8,17
Type:  Splice variant
Species:  Human
Description:  LRH-1v2: smallest isoform, contains deletion within the D and E domains, caused by another alternative splicing event in exon 5, and cannot activate transcription although the transcription factors involved have not yet been identified.
Amino acids:  495
Protein accession: 
References:  17,31
General Comments
Reported to be stimulated by dilauroylphosphatidylcholine [13,22].

References

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1. Boerboom D, Pilon N, Behdjani R, Silversides DW, Sirois J. (2000) Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process. Endocrinology141 (12): 4647-56. [PMID:11108279]

2. Botrugno OA, Fayard E, Annicotte JS, Haby C, Brennan T, Wendling O, Tanaka T, Kodama T, Thomas W, Auwerx J, Schoonjans K. (2004) Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol. Cell15 (4): 499-509. [PMID:15327767]

3. Brendel C, Gelman L, Auwerx J. (2002) Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol. Endocrinol.16 (6): 1367-77. [PMID:12040021]

4. Clyne CD, Speed CJ, Zhou J, Simpson ER. (2002) Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J. Biol. Chem.277 (23): 20591-7. [PMID:11927588]

5. Delerive P, Galardi CM, Bisi JE, Nicodeme E, Goodwin B. (2004) Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription. Mol. Endocrinol.18 (10): 2378-87. [PMID:15218078]

6. Fahmi AI, Patel M, Stevens EB, Fowden AL, John JE, Lee K, Pinnock R, Morgan K, Jackson AP, Vandenberg JI. (2001) The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart. J. Physiol. (Lond.)537 (Pt 3): 693-700. [PMID:11744748]

7. Freeman LA, Kennedy A, Wu J, Bark S, Remaley AT, Santamarina-Fojo S, Brewer HB. (2004) The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. J. Lipid Res.45 (7): 1197-206. [PMID:15121760]

8. Galarneau L, Drouin R, Bélanger L. (1998) Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization. Cytogenet. Cell Genet.82 (3-4): 269-70. [PMID:9858833]

9. Galarneau L, Paré JF, Allard D, Hamel D, Levesque L, Tugwood JD, Green S, Bélanger L. (1996) The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family. Mol. Cell. Biol.16 (7): 3853-65. [PMID:8668203]

10. Hinshelwood MM, Repa JJ, Shelton JM, Richardson JA, Mangelsdorf DJ, Mendelson CR. (2003) Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol. Cell. Endocrinol.207 (1-2): 39-45. [PMID:12972182]

11. Kim JW, Havelock JC, Carr BR, Attia GR. (2005) The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells. J. Clin. Endocrinol. Metab.90 (3): 1678-85. [PMID:15613430]

12. Kim JW, Peng N, Rainey WE, Carr BR, Attia GR. (2004) Liver receptor homolog-1 regulates the expression of steroidogenic acute regulatory protein in human granulosa cells. J. Clin. Endocrinol. Metab.89 (6): 3042-7. [PMID:15181096]

13. Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature474 (7352): 506-10. [PMID:21614002]

14. Li M, Xie YH, Kong YY, Wu X, Zhu L, Wang Y. (1998) Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus. J. Biol. Chem.273 (44): 29022-31. [PMID:9786908]

15. Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE. (2005) Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proc. Natl. Acad. Sci. U.S.A.102 (27): 9505-10. [PMID:15976031]

16. Liu DL, Liu WZ, Li QL, Wang HM, Qian D, Treuter E, Zhu C. (2003) Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary. Biol. Reprod.69 (2): 508-17. [PMID:12672674]

17. Nitta M, Ku S, Brown C, Okamoto AY, Shan B. (1999) CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc. Natl. Acad. Sci. U.S.A.96 (12): 6660-5. [PMID:10359768]

18. Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. (2005) Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat. Struct. Mol. Biol.12 (4): 357-63. [PMID:15723037]

19. Pare JF, Roy S, Galarneau L, Belanger L. (2001) The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promoters. J. Biol. Chem.276 (16): 13136-44. [PMID:11145965]

20. Paré JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Bélanger L. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J. Biol. Chem.279 (20): 21206-16. [PMID:15014077]

21. Qin J, Gao DM, Jiang QF, Zhou Q, Kong YY, Wang Y, Xie YH. (2004) Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol. Endocrinol.18 (10): 2424-39. [PMID:15205472]

22. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. (2009) Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol. Endocrinol.23 (1): 25-34. [PMID:18988706]

23. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. (2003) Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol. Cell11 (6): 1575-85. [PMID:12820970]

24. Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, Auwerx J. (2002) Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep.3 (12): 1181-7. [PMID:12446566]

25. Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, Auwerx J. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc. Natl. Acad. Sci. U.S.A.102 (6): 2058-62. [PMID:15684064]

26. Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V, Rainey WE. (2002) Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes. J. Endocrinol.174 (3): R13-7. [PMID:12208674]

27. Steffensen KR, Holter E, Båvner A, Nilsson M, Pelto-Huikko M, Tomarev S, Treuter E. (2004) Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. EMBO Rep.5 (6): 613-9. [PMID:15143342]

28. Wang ZN, Bassett M, Rainey WE. (2001) Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase. J. Mol. Endocrinol.27 (2): 255-8. [PMID:11564608]

29. Weck J, Mayo KE. (2006) Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells. Mol. Endocrinol.20 (5): 1090-103. [PMID:16423880]

30. Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell116: 883-895. [PMID:15035989]

31. Zhang CK, Lin W, Cai YN, Xu PL, Dong H, Li M, Kong YY, Fu G, Xie YH, Huang GM, Wang Y. (2001) Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene. Gene273 (2): 239-49. [PMID:11595170]

How to cite this page

5A. Fushi tarazu F1-like receptors: Liver receptor homolog-1. Last modified on 13/12/2013. Accessed on 31/07/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=633.