CCR7 | Chemokine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

CCR7

Target id: 64

Nomenclature: CCR7

Family: Chemokine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     CCR7 has curated GtoImmuPdb data

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 378 17q12-q21.2 CCR7 C-C motif chemokine receptor 7 47
Mouse 7 378 11 D Ccr7 chemokine (C-C motif) receptor 7 47
Rat 7 378 10q31 Ccr7 C-C motif chemokine receptor 7
Previous and Unofficial Names
EBI-1 [47,59] | CD197
Database Links
Specialist databases
GPCRDB ccr7_human (Hs), ccr7_mouse (Mm), q6u2d6_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
CCL19 {Sp: Human}
CCL21 {Sp: Human}
CCL19 {Sp: Mouse}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CCL19 {Sp: Human} Hs Agonist 10.0 pKd 53
pKd 10.0 (Kd 1x10-10 M) [53]
Ccl21b {Sp: Mouse} Hs Agonist 9.9 pKd 53
pKd 9.9 (Kd 1.34x10-10 M) [53]
CCL21 {Sp: Human} Hs Agonist 9.3 pIC50 60
pIC50 9.3 [60]
CCL19 {Sp: Human} Hs Agonist 7.7 – 9.0 pIC50 40,59-60
pIC50 7.7 – 9.0 [40,59-60]
Ccl21b {Sp: Mouse} Hs Agonist 8.3 pIC50 40
pIC50 8.3 (IC50 4.7x10-9 M) [40]
CCL19 {Sp: Mouse} Mm Agonist - - 34
[34]
Ccl21a {Sp: Mouse} Mm Agonist - - 34
[34]
Ccl21b {Sp: Mouse} Mm Agonist - - 34
[34]
View species-specific agonist tables
Agonist Comments
CCL19 but not CCL21 leads to CCR7 phosphorylation and internalization.
Antibody Comments
An anti-CCR7 monoclonal antibody (mouse anti-human CCR7 mAb, 150503 clone) is reported to have potent anti-tumor activity in mice xenografted with human mantle cell lymphoma cells [49].
Immunopharmacology Comments
CCR7 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0002407 dendritic cell chemotaxis IC
GO:0002408 myeloid dendritic cell chemotaxis IDA
GO:0002885 positive regulation of hypersensitivity ISS
GO:0006954 inflammatory response NAS
GO:0090023 positive regulation of neutrophil chemotaxis IDA
GO:0097022 lymphocyte migration into lymph node TAS
GO:2000510 positive regulation of dendritic cell chemotaxis ISS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0001768 establishment of T cell polarity IC
GO:2000525 positive regulation of T cell costimulation ISS
click arrow to show/hide IEA associations
GO:0045060 negative thymic T cell selection IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 8 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0002885 positive regulation of hypersensitivity ISS
GO:0002922 positive regulation of humoral immune response ISS
GO:0090023 positive regulation of neutrophil chemotaxis IDA
GO:2000510 positive regulation of dendritic cell chemotaxis ISS
GO:2000522 positive regulation of immunological synapse formation ISS
GO:2000525 positive regulation of T cell costimulation ISS
click arrow to show/hide IEA associations
GO:0050862 positive regulation of T cell receptor signaling pathway IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0097029 mature conventional dendritic cell differentiation ISS
click arrow to show/hide IEA associations
GO:0045060 negative thymic T cell selection IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 8 GO processes
GO:0016493 C-C chemokine receptor activity ISS
GO:0032649 regulation of interferon-gamma production ISS
GO:0032735 positive regulation of interleukin-12 production ISS
GO:0038117 C-C motif chemokine 19 receptor activity IDA
GO:0038121 C-C motif chemokine 21 receptor activity IDA
GO:0050706 regulation of interleukin-1 beta secretion ISS
GO:0071345 cellular response to cytokine stimulus IDA
GO:0072610 interleukin-12 secretion ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 6 GO processes
GO:0002407 dendritic cell chemotaxis IC
GO:0002408 myeloid dendritic cell chemotaxis IDA
GO:0090023 positive regulation of neutrophil chemotaxis IDA
GO:0097022 lymphocyte migration into lymph node TAS
GO:2000510 positive regulation of dendritic cell chemotaxis ISS
GO:2000525 positive regulation of T cell costimulation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0001768 establishment of T cell polarity IC
GO:2000522 positive regulation of immunological synapse formation ISS
GO:2000525 positive regulation of T cell costimulation ISS
GO:2000526 positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation ISS
click arrow to show/hide IEA associations
GO:0045060 negative thymic T cell selection IEA
GO:0050862 positive regulation of T cell receptor signaling pathway IEA
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Calcium channel
References:  43,53-54
Secondary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Other - See Comments
Comments:  Activation of the MAPK cascade.
CCR7 mediates Jak2 and Jak3 phosphorylation in CCL21 treated murine T cells [13,52].
References:  22
Tissue Distribution
Bone marrow stromal cells (BMSCs).
Species:  Human
Technique:  Flow cytometry and RT-PCR.
References:  16
T cells.
Species:  Human
Technique:  Multicolor flow cytometry.
References:  20
Natural killer (NK) cells.
Species:  Human
Technique:  Flow cytometric and RNase protection assay.
References:  18
Blood T lymphocytes.
Species:  Human
Technique:  Flow cytometry.
References:  1
Central memory T cells.
Species:  Human
Technique:  Flow cytometry.
References:  44
Dendritic cells, mature.
Species:  Human
Technique:  Flow cytometry.
References:  45
Inflamed synovial tissue.
Species:  Human
Technique:  Immunohistochemistry.
References:  14
B cells.
Species:  Mouse
Technique:  Flow cytometry.
References:  42
Plasmacytoid dendritic cells.
Species:  Mouse
Technique:  Flow cytometry.
References:  48
Neutrophils.
Species:  Mouse
Technique:  Flow cytometry.
References:  2
Monocytes.
Species:  Mouse
Technique:  RT-PCR.
References:  41
Mature dendritic cells.
Species:  Mouse
Technique:  Western blotting.
References:  56
Regulatory T cells.
Species:  Mouse
Technique:  Flow cytometry.
References:  46
T cells.
Species:  Mouse
Technique:  Microarray analysis, RNase protection assay, Western blotting and in vitro chemokine transmigration assays.
References:  33
Hippocampus.
Species:  Mouse
Technique:  Flow cytometry and immunohistochemistry.
References:  27
DN thymocytes, SP thymocytes.
Species:  Mouse
Technique:  Flow cytometry.
References:  32
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of chemotaxis of murine L1.2 cells transfected with the human CCR7 receptor.
Species:  Human
Tissue:  Murine L1.2 cells.
Response measured:  Chemotaxis.
References:  60
Measurement of Ca2+ levels in K562 cells transfected with the human CCR7 receptor.
Species:  Human
Tissue:  K562 cells.
Response measured:  Ca2+ mobilisation.
References:  59
Measurement of chemotaxis of HEK 293/EBNA-1 cells transfected with the human CCR7 receptor.
Species:  Human
Tissue:  HEK 293/EBNA-1 cells.
Response measured:  Chemotaxis.
References:  59
Measurement of Ca2+ levels in murine L1.2 cells transfected with the human CCR7 receptor.
Species:  Human
Tissue:  Murine L1.2 cells.
Response measured:  Ca2+ mobilisation.
References:  60
Measurement of the phosphorylation of MAPKs (ERK1/2, JNK, and p38) in dendritic cells endogenously expressing the CCR7 receptor.
Species:  Human
Tissue:  Dendritic cells.
Response measured:  PTX-sensitive activation of ERK1/2, JNK, and p38.
References:  43
Measurement of MAP kinase activity in HEK 293 cells transfected with the human CCR7 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Activation of ERK1/2.
References:  22
Measurement of chemotaxis of murine CCR7-deficient T cells expressing human CCR7.
Species:  Mouse
Tissue:  T cells isolated from lymph nodes.
Response measured:  Chemotaxis.
References:  57
Physiological Functions
Organogenesis (cooperative with the CXCR5 receptor).
Species:  Mouse
Tissue:  Lymphoid organ.
References:  37
Antiapoptotic signalling.
Species:  Human
Tissue:  Dendritic cells.
References:  54
Positioning of lymphocytes within defined compartments in secondary lymphoid organs.
Species:  Mouse
Tissue:  Lymph nodes.
References:  11
Migration of Langerhans cells from the skin to skin draining lymph nodes.
Species:  Mouse
Tissue:  Lymph nodes.
References:  38
Migration of bone marrow-derived T cell precursors into the thymus (in synergy with CCR9 and CXCR4).
Species:  Mouse
Tissue:  Thymus.
References:  5,23
Migration of CD4 and CD8 single positive thymocytes from the thymic cortex to the medulla upon positive selection.
Species:  Mouse
Tissue:  Thymus.
References:  8
Entry of naïve lymphocytes into lymph nodes and Peyer's patches through high endothelial venules.
Species:  Mouse
Tissue:  Secondary lymphoid organs.
References:  12
Enables antigen specific DC-T cell interactions in the lymph node paracortex and splenic PALS.
Species:  Mouse
Tissue:  Lymph nodes, spleen.
References:  11
Enables efficient B cell priming in T cell dependent immune responses.
Species:  Mouse
Tissue:  Lymph nodes, spleen.
References:  11
Enables egress of effector T cells from peripheral tissues.
Species:  Mouse
Tissue:  Skin, lung.
References:  4,9
Physiological Consequences of Altering Gene Expression
CXCR5-/- CCR7-/- double knockout mice exhibit decreased B cell levels in the peritoneal cavity as well as reduced IgM responses to administration of Streptococcus pneumoniae.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17
CCR7 receptor knockout mice exhibit profound disorganisation of secondary lymphoid tissue and defective primary immune responses.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  11
CCR7-/- CXCR5-/- double knockout mice lack peripheral lymph nodes.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  37
Aged CCR7-/- mice develop multi-organ autoimmunity.
Species:  Mouse
Tissue:  Stomach, salivary glands, pancreas.
Technique:  Gene knock-outs
References:  7
CCR7-/- mice develop spontaneous bronchial associated lymphoid tissue from day 5 p.n.
Species:  Mouse
Tissue:  Lung
Technique:  Gene knock-outs
References:  7
CCR7-/- mice display severely impaired migration of naïve T cells into lymph nodes and Peyer' s patches.
Species:  Mouse
Tissue:  Lymph nodes, Peyer's patches.
Technique:  Gene knock-outs
References:  11
CCR7-/- mice develop reduced atherosclerotic plaques.
Species:  Mouse
Tissue:  Arterial vessels.
Technique:  Gene knock-outs
References:  29
CCR7-/- mice succumb to acute T. gondii infection.
Species:  Mouse
Tissue:  Lung, liver and brain.
Technique:  Gene knock-outs
References:  36
Single positive thymocytes in CCR7-/- mice are retained in the thymic cortex rather than migrating to the medulla .
Species:  Mouse
Tissue:  Thymus.
Technique:  Gene knock-outs
References:  55
CCR7-/- mice develop dacryoadenitis and sialadenitis.
Species:  Mouse
Tissue:  Lacrimal and salivary glands.
Technique:  Gene knock-outs
References:  25
CR7-/- mice show significantly reduced volume of thymic medulla.
Species:  Mouse
Tissue:  Thymus.
Technique:  Gene knock-outs
References:  55
CCR7-/- mice display aberrant activation of B cells and abnormal class switch recombination.
Species:  Mouse
Tissue: 
Technique:  Gene knock-outs
References:  11,35
CCR7-/- T cells show reduced motility in lymph nodes.
Species:  Mouse
Tissue:  Lymph nodes.
Technique:  Gene knock-outs
References:  39,58
Xenobiotics Influencing Gene Expression
Nickel (NiSO4) and 2,4-dinitrochlorobenzene (DNCB) induce CCR7 expression.
Species:  Human
Tissue:  Dendritic cells.
Technique: 
References:  3
Synthetic oligodeoxynucleotide with CpG motif leads to CCR7 upregulation.
Species:  Human
Tissue:  Plasmacytoid dendritic cells.
Technique: 
References:  24
Dexamethasone inhibits CCR7 expression, whereas rapamycin mediates CCR7 upregulation.
Species:  Human
Tissue:  Dendritic cells.
Technique: 
References:  50
Triptolide inhibits LPS-induced CCR7 upregulation.
Species:  Mouse
Tissue:  Bone marrow derived dendritic cells.
Technique: 
References:  28
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008217 abnormal B cell activation PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002459 abnormal B cell physiology PMID: 10520991 
Ccr7tm1Rfor|Tg(DO11.10)10Dlo Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
involves: 129P2/OlaHsd
MGI:103011  MGI:2664401  MP:0003091 abnormal cell migration PMID: 17474155 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0004816 abnormal class switch recombination PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002376 abnormal dendritic cell physiology PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MGI:103011  MP:0002376 abnormal dendritic cell physiology PMID: 18451854 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0002163 abnormal gland morphology PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0001800 abnormal humoral immune response PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0001346 abnormal lacrimal gland morphology PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0003156 abnormal leukocyte migration PMID: 10520991 
Ccr7tm1Rfor|Tg(DO11.10)10Dlo Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
involves: 129P2/OlaHsd
MGI:103011  MGI:2664401  MP:0003156 abnormal leukocyte migration PMID: 17474155 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0003156 abnormal leukocyte migration PMID: 15302902  16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002343 abnormal lymph node cortex PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008522 abnormal lymph node germinal center PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002347 abnormal lymph node T cell domain PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0003452 abnormal parotid gland morphology PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002392 abnormal Peyer's patch T cell area PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0008872 abnormal physiological response to xenobiotic PMID: 16473829 
Ccr7tm1Rfor|Tg(DO11.10)10Dlo Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
involves: 129P2/OlaHsd
MGI:103011  MGI:2664401  MP:0004946 abnormal regulatory T cell physiology PMID: 17474155 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002363 abnormal spleen marginal sinus morphology PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002356 abnormal spleen red pulp morphology PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0003793 abnormal submandibular gland morphology PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002444 abnormal T cell physiology PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0002371 abnormal thymus cortex morphology PMID: 15302902 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0002375 abnormal thymus medulla morphology PMID: 15302902 
Ccr7tm1Dgen Ccr7tm1Dgen/Ccr7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:103011  MP:0002499 chronic inflammation
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008075 decreased CD4-positive T cell number PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008127 decreased dendritic cell number PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008498 decreased IgG3 level PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0005616 decreased susceptibility to type IV hypersensitivity reaction PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0005018 decreased T cell number PMID: 10520991 
Ccr7Gt(hpk)Byg Ccr7Gt(hpk)Byg/Ccr7Gt(hpk)Byg
involves: 129 * C57BL/6
MGI:103011  MP:0003008 enhanced long term potentiation PMID: 9825957 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0000691 enlarged spleen PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008074 increased CD4-positive T cell number PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002497 increased IgE level PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008499 increased IgG1 level PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008500 increased IgG2a level PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0001846 increased inflammatory response PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0005350 increased susceptibility to autoimmune disorder PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0005015 increased T cell number PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0008880 lacrimal gland inflammation PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
B6.129P2-Ccr7
MGI:103011  MP:0001870 salivary gland inflammation PMID: 16473829 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0002217 small lymph nodes PMID: 10520991 
Ccr7tm1Rfor Ccr7tm1Rfor/Ccr7tm1Rfor
involves: 129P2/OlaHsd * BALB/c
MGI:103011  MP:0008135 small Peyer's patches PMID: 10520991 
Clinically-Relevant Mutations and Pathophysiology
Disease:  B-cell chronic lymphocytic leukemia
Description: B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma.
Synonyms: B-CLL
lymphoplasmacytic leukemia
small lymphocytic lymphoma
OMIM: 151400
Orphanet: ORPHA67038
References:  15
Disease:  Breast cancer
Disease Ontology: DOID:1612
OMIM: 114480
References:  21
Disease:  Esophageal cancer
Disease Ontology: DOID:5041
OMIM: 133239
References:  19
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
References:  31
Disease:  Mantle cell lymphoma
Disease Ontology: DOID:0050746
Orphanet: ORPHA52416
References:  30
Disease:  Ovarian cancer
Disease Ontology: DOID:2394
OMIM: 167000
References:  6
Disease:  Pancreatic cancer
Disease Ontology: DOID:1793
OMIM: 260350
References:  51
Disease:  Squamous cell carcinoma, head and neck
Synonyms: HNSCC
OMIM: 275355
Orphanet: ORPHA67037
References:  26
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Description:  The rs3136687 and rs11574665 SNPs in intron 1 are significantly associated with risk of chronic lymphocytic leukemia.
SNP accession: 
References:  10

References

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1. Bardi G, Lipp M, Baggiolini M, Loetscher P. (2001) The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur J Immunol, 31: 3291-3297. [PMID:11745346]

2. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML, Magistrelli G, Masternak K, Chevailler A, Delneste Y et al.. (2011) CCR7 is involved in the migration of neutrophils to lymph nodes. Blood, 117 (4): 1196-204. [PMID:21051556]

3. Boislève F, Kerdine-Römer S, Rougier-Larzat N, Pallardy M. (2004) Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. J. Invest. Dermatol., 123 (3): 494-502. [PMID:15304089]

4. Brown MN, Fintushel SR, Lee MH, Jennrich S, Geherin SA, Hay JB, Butcher EC, Debes GF. (2010) Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. J. Immunol., 185 (8): 4873-82. [PMID:20833836]

5. Calderón L, Boehm T. (2011) Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc. Natl. Acad. Sci. U.S.A., 108 (18): 7517-22. [PMID:21502490]

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Israel F. Charo, Reinhold Förster, Rebecca Hills, Richard Horuk, Kouji Matsushima, Georgios L Moschovakis, Philip M. Murphy, Joost J. Oppenheim.
Chemokine receptors: CCR7. Last modified on 19/02/2018. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=64.