GPR107

Target id: 651

Nomenclature: GPR107

Family: Other 7TM proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 600 9q34.11 GPR107 G protein-coupled receptor 107
Mouse 7 551 2 B Gpr107 G protein-coupled receptor 107
Rat 7 551 3p12 Gpr107 G protein-coupled receptor 107
Previous and Unofficial Names
LUSTR1
GCDRP
Lung seven transmembrane receptor 1
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NeXtProt
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
neuronostatin {Sp: Human, Pig}
Comments: Proposed ligand, single publication
General Comments
GPR107 is a member of the LUSTR family of proteins found in both plants and animals, having similar topology to G protein-coupled receptors [1]. GPR107 shows no homology to known G protein-coupled receptors.

Neuronostatin, an endogenous peptide from the somatostatin precursor, has been demonstated to be a ligand for GPR107 in one publication [2].

References

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1. Edgar AJ. (2007) Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. DNA Seq.18 (3): 235-41. [PMID:17454009]

2. Yosten GL, Redlinger LJ, Samson WK. (2012) Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am. J. Physiol. Regul. Integr. Comp. Physiol.303 (9): R941-9. [PMID:22933024]

How to cite this page

Other 7TM proteins: GPR107. Last modified on 21/09/2015. Accessed on 24/01/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=651.