ASIC2 | Acid-sensing (proton-gated) ion channels (ASICs) | IUPHAR/BPS Guide to PHARMACOLOGY

ASIC2

Target id: 685

Nomenclature: ASIC2

Family: Acid-sensing (proton-gated) ion channels (ASICs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ASIC2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 17q11.2-q12 ASIC2 acid sensing ion channel subunit 2
Mouse - - 11 B5 Asic2 acid-sensing (proton-gated) ion channel 2
Rat - - 10q26 Asic2 acid sensing ion channel subunit 2
Previous and Unofficial Names
BNaC1 | BNC1 | ACCN | ACCN1 | ASIC2a | amiloride-sensitive cation channel 1, neuronal | degenerin | acid-sensing ion channel 2 | amiloride-sensitive brain sodium channel 2 | amiloride-sensitive cation channel 1 | BNC1k | brain sodium channel 1 | BNaC1a | acid-sensing (proton-gated) ion channel 2 | acid sensing (proton gated) ion channel 2
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Functional Characteristics
γ~10.4-13.4 pS
PNa/PK =10, PNa/PCa = 20
rapid activation rate, moderate inactivation rate (3.3-5.5 s) @ pH 5
Natural/Endogenous Ligands
H+

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
Extracellular H+ Hs - ~4.1 – 5.0 pEC50 - no
pEC50 ~4.1 – 5.0 (EC50 ~8x10-5 – 1x10-5 M)
Not voltage dependent
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
amiloride Hs - no 4.6 pIC50 - no
pIC50 4.6 (IC50 2.8x10-5 M)
Not voltage dependent
A-317567 Hs - no ~4.5 pIC50 - no
pIC50 ~4.5 (IC50 ~3x10-5 M)
Not voltage dependent
nafamostat Hs - no ~4.2 pIC50 - no
pIC50 ~4.2 (IC50 ~7x10-5 M)
Not voltage dependent
Cd2+ Hs - no ~3.0 pIC50 - no
pIC50 ~3.0 (IC50 ~1x10-3 M)
Not voltage dependent

Contributors

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How to cite this page

Stephan Kellenberger, Laurent Schild.
Acid-sensing (proton-gated) ion channels (ASICs): ASIC2. Last modified on 13/03/2018. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=685.