ABCB3

Target id: 770

Nomenclature: ABCB3

Abbreviated Name: TAP2

Systematic Nomenclature: ABCB3

Family: ABCB subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     ABCB3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - TAP2 transporter 2, ATP binding cassette subfamily B member
Mouse - - Tap2 transporter 2
Rat - - Tap2 transporter 2
Previous and Unofficial Names
Antigen peptide transporter 2 (APT2) | peptide supply factor 2 (PSF-2) | Peptide transporter TAP2 | MTP2 | ATP-binding cassette sub-family B member 3 | Cim | Transporter 2 ABC (ATP binding cassette) | Ham2 | peptide transporter involved in antigen processing 2 | RING11 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | transporter 2 | transporter 2, ATP binding cassette subfamily B member
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
TAP1 (ABCB2) and TAP2 (ABCB3) form a transporter that plays an important role in antigen presentation by major histocompatibility complex class I (MHCI) molecules in the adaptive immune response [1].
Immuno Process Associations
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) TAS
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) TAS
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent (GO:0002489) IMP
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) IDA
peptide antigen transport (GO:0046968) IDA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 

References

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1. Seyffer F, TampĂ© R. (2015) ABC transporters in adaptive immunity. Biochim. Biophys. Acta1850 (3): 449-60. [PMID:24923865]

Contributors

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How to cite this page

Mary Vore.
ABCB subfamily: ABCB3. Last modified on 19/04/2017. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=770.