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Target not currently curated in GtoImmuPdb
Target id: 792
Nomenclature: ABCG2
Abbreviated Name: ABCP
Systematic Nomenclature: ABCG2
Family: ABCG subfamily
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 655 | 4q22.1 | ABCG2 | ATP binding cassette subfamily G member 2 (JR blood group) | |
| Mouse | 6 | 657 | 6 27.82 cM | Abcg2 | ATP binding cassette subfamily G member 2 (Junior blood group) | |
| Rat | 6 | 657 | 4q24 | Abcg2 | ATP binding cassette subfamily G member 2 | |
| Previous and Unofficial Names |
| BCRP | breast cancer resistance protein | mitoxantrone resistance-associated protein | MXR | Placenta-specific ATP- binding cassette transporter | ABCP | CD338 | ATP-binding cassette protein G2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette, sub-family G (WHITE), member 2 | BCRP1 | breast cancer resistance protein 1 homolog | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | ATP-binding cassette, subfamily G (WHITE), member 2 | ATP-binding cassette | ATP binding cassette subfamily G member 2 (Junior blood group) |
| Database Links |
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| Alphafold | Q9UNQ0 (Hs), Q7TMS5 (Mm), Q80W57 (Rn) |
| ChEMBL Target | CHEMBL5393 (Hs), CHEMBL2073705 (Mm), CHEMBL3509585 (Rn) |
| Ensembl Gene | ENSG00000118777 (Hs), ENSMUSG00000029802 (Mm), ENSRNOG00000007041 (Rn) |
| Entrez Gene | 9429 (Hs), 26357 (Mm), 312382 (Rn) |
| Human Protein Atlas | ENSG00000118777 (Hs) |
| KEGG Gene | hsa:9429 (Hs), mmu:26357 (Mm), rno:312382 (Rn) |
| OMIM | 603756 (Hs) |
| Pharos | Q9UNQ0 (Hs) |
| UniProtKB | Q9UNQ0 (Hs), Q7TMS5 (Mm), Q80W57 (Rn) |
| Wikipedia | ABCG2 (Hs) |
| Selected 3D Structures |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific inhibitor tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| General Comments |
| ABCG2 causes multidrug resistance in cancer [1-3]. |
1. Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res, 58 (23): 5337-9. [PMID:9850061]
2. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA, 95 (26): 15665-70. [PMID:9861027]
3. Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Cristensen B, Brangi M, Greenberger L, Dean M, Fojo T et al.. (1999) Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res, 59 (1): 8-13. [PMID:9892175]
4. Ozvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, Sarkadi B. (2001) Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun, 285 (1): 111-7. [PMID:11437380]
5. Silbermann K, Stefan SM, Elshawadfy R, Namasivayam V, Wiese M. (2019) Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. J Med Chem, 62 (9): 4383-4400. [PMID:30925062]
6. Taylor NMI, Manolaridis I, Jackson SM, Kowal J, Stahlberg H, Locher KP. (2017) Structure of the human multidrug transporter ABCG2. Nature, 546 (7659): 504-509. [PMID:28554189]
