Alanine/serine/cysteine transporter 2 | Alanine/serine/cysteine transporter subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

Alanine/serine/cysteine transporter 2

Target id: 874

Nomenclature: Alanine/serine/cysteine transporter 2

Abbreviated Name: ASCT2

Systematic Nomenclature: SLC1A5

Family: Alanine/serine/cysteine transporter subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Alanine/serine/cysteine transporter 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC1A5 solute carrier family 1 member 5
Mouse - - Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5
Rat - - Slc1a5 solute carrier family 1 member 5
Previous and Unofficial Names
AAAT | hATB0 | Neutral amino acid transporter B(0) | ASCT2 | RDRC | sodium-dependent neutral amino acid transporter ASCT2 | CAZ-associated structural protein | H4-ASCT2 | H4-system ASC-like transporter | Slc1a7 | solute carrier family 1, member 7 | solute carrier family 1 (neutral amino acid transporter), member 5 | solute carrier family 1 (neutral amino acid transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC1A5 (Hs)
Other databases
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Cryo-EM structure of the human neutral amino acid transporter ASCT2
PDB Id:  6GCT
Resolution:  3.85Å
Species:  Human
References:  3
Stoichiometry
1 Na+: 1 amino acid (in): 1 Na+: 1 amino acid (out); (homo-, or hetero-exchange; [1])
Endogenous substrates (Human)
L-alanine = L-serine = L-cysteine (low Vmax) = L-threonine = L-glutamine = L-asparagine >> L-methionineglycineL-leucine > L-valine > L-glutamic acid (enhanced at low pH)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
p-nitrophenyl glutamyl anilide Rn Inhibition 4.3 pKi 2
pKi 4.3 (Ki 5.5x10-5 M) [2]
benzylcysteine Hs Inhibition 3.1 pKi 4
pKi 3.1 (Ki 7.8x10-4 M) [4]
benzylserine Hs Inhibition 3.0 pKi 4
pKi 3.0 (Ki 9x10-4 M) [4]
View species-specific inhibitor tables

References

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1. Bröer A, Brookes N, Ganapathy V, Dimmer KS, Wagner CA, Lang F, Bröer S. (1999) The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. J. Neurochem., 73 (5): 2184-94. [PMID:10537079]

2. Esslinger CS, Cybulski KA, Rhoderick JF. (2005) Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site. Bioorg. Med. Chem., 13 (4): 1111-8. [PMID:15670919]

3. Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ. (2018) Cryo-EM structure of the human neutral amino acid transporter ASCT2. Nat. Struct. Mol. Biol., 25 (6): 515-521. [PMID:29872227]

4. Grewer C, Grabsch E. (2004) New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J. Physiol. (Lond.), 557 (Pt 3): 747-59. [PMID:15107471]

How to cite this page

Alanine/serine/cysteine transporter subfamily: Alanine/serine/cysteine transporter 2. Last modified on 23/07/2018. Accessed on 19/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=874.