NRAMP1

Target id: 966

Nomenclature: NRAMP1

Systematic Nomenclature: SLC11A1

Family: SLC11 family of proton-coupled metal ion transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     NRAMP1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC11A1 solute carrier family 11 member 1
Mouse - - Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Rat - - Slc11a1 solute carrier family 11 member 1
Previous and Unofficial Names
LSH | NRAMP | Bcg | Itg | natural resistance associated macrophage protein 1 | Ity | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporters)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC11A1 (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Fe2+ Hs - -
Mn2+ Hs - -
Stoichiometry
1 H+ : 1 Fe2+ (out) or 1 Fe2+ (in) : 1 H+ (out)
Immunopharmacology Comments
NRAMP1 / SLC11A1 appears to be involved in macrophage antimicrobial action against intracellular pathogens, and although its precise mechanism is not fully resolved, evidence indicates its involvement in the activation of phagocytes and synthesis of proinflammatory cytokines. Polymorphisms in the human SLC11A1 gene have been associated with susceptibility to several infections [1,3-4], and more recently in genetic susceptibility to development of rheumatoid arthritis [2] (describing a protective role for the SLC11A1D543N variant in the tested population) .
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 8 GO processes
GO:0002309 T cell proliferation involved in immune response ISS
GO:0002369 T cell cytokine production ISS
GO:0006909 phagocytosis ISS
GO:0006954 inflammatory response ISS
GO:0034341 response to interferon-gamma ISS
GO:0042116 macrophage activation ISS
GO:0043312 neutrophil degranulation TAS
GO:0050766 positive regulation of phagocytosis ISS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 4 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0006909 phagocytosis ISS
GO:0048002 antigen processing and presentation of peptide antigen ISS
GO:0050766 positive regulation of phagocytosis ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0002309 T cell proliferation involved in immune response ISS
GO:0002369 T cell cytokine production ISS
GO:0002827 positive regulation of T-helper 1 type immune response ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0002369 T cell cytokine production ISS
GO:0002827 positive regulation of T-helper 1 type immune response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0002827 positive regulation of T-helper 1 type immune response ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0001818 negative regulation of cytokine production ISS
GO:0001819 positive regulation of cytokine production ISS
GO:0002369 T cell cytokine production ISS
GO:0032623 interleukin-2 production ISS
GO:0032632 interleukin-3 production ISS
GO:0032729 positive regulation of interferon-gamma production ISS
GO:0034341 response to interferon-gamma ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002309 T cell proliferation involved in immune response ISS
GO:0042116 macrophage activation ISS
GO:0043312 neutrophil degranulation TAS

References

Show »

1. Brochado MJ, Gatti MF, Zago MA, Roselino AM. (2016) Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample. Mem. Inst. Oswaldo Cruz, 111 (2): 101-5. [PMID:26814595]

2. Niño-Moreno P, Turrubiartes-Martínez E, Oceguera-Maldonado B, Baltazar-Benítez N, Negrete-González C, Oliva-Ramírez B, Baranda L, González-Amaro R. (2017) The Role of NRAMP1/SLC11A1 Gene Variant D543N (1730G/A) in the Genetic Susceptibility to Develop Rheumatoid Arthritis in the Mexican Mestizo population. Rev. Invest. Clin., 69 (1): 5-10. [PMID:28239176]

3. Somuk BT, Koc S, Ates O, Göktas G, Soyalic H, Uysal IO, Gurbuzler L, Sapmaz E, Sezer S, Eyibilen A. (2016) MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. Acta Otolaryngol., 136 (11): 1168-1172. [PMID:27223255]

4. Sophie M, Hameed A, Muneer A, Samdani AJ, Saleem S, Azhar A. (2017) SLC11A1 polymorphisms and host susceptibility to cutaneous leishmaniasis in Pakistan. Parasit Vectors, 10 (1): 12. [PMID:28061874]

How to cite this page

SLC11 family of proton-coupled metal ion transporters: NRAMP1. Last modified on 19/04/2017. Accessed on 19/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=966.