<i>GPR27</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR27

Target id: 97

Nomenclature: GPR27

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR27 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 375 3p21-p14 GPR27 G protein-coupled receptor 27 3-4
Mouse 7 379 6 E1 Gpr27 G protein-coupled receptor 27
Rat 7 377 4q34 Gpr27 G protein-coupled receptor 27
Previous and Unofficial Names
super conserved receptor expressed in brain 1 | SREB1
Database Links
Specialist databases
GPCRDB gpr27_human (Hs), gpr27_mouse (Mm), gpr27_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Comments:  Alteration of gene expression affects stimulation of IP3 [1]
References: 
Tissue Distribution
Brain (caudate nucleus, putamen, hippocampus, subthalamic nucleus), ovary, testis, heart, prostate, pancreas, peripheral leukocytes
Species:  Human
Technique:  Northern Blot
References:  3
Cerebral cortex (piriform cortex, anterior cingulate, frontoparietal, somatosensory areas); caudate putamen, nucleus accumbens; hypothalamic nuclei (suprachiasmatic, supraoptic, ventromedial, paraventricular, arcuate)
Species:  Rat
Technique:  in situ hybridisation
References:  4
Whole brain, hippocampus, striatum, frontal cortex, thalamus, pons, hypothalamus
Species:  Rat
Technique:  Northern Blot
References:  4
Tissue Distribution Comments
GPR27 has been detected at higher levels in fetal brains than in adult brains, suggesting a role in neural plasticity. The receptor is highly conserved amongst mammals, with expression seen in grey matter areas of the monkey brain (hippocampal dentate gyrus and supraoptic nucleus of the hypothalamus) as demonstrated by in situ hybridisation [2].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Overexpression of Gpr27 increases inositol trisphosphate levels with no effect on cAMP
Species:  Mouse
Tissue:  MIN6 cells
Technique:  Gene overexpression
References:  1
Knockdown of Gpr27 reduces endogenous mouse insulin promotor activity and glucose stimulated insulin secretion
Species:  Mouse
Tissue:  Pancreatic β cells
Technique:  RNA interference
References:  1
Clinically-Relevant Mutations and Pathophysiology Comments
GPR27 mapped to a 15Mb constitutional de novo interstitial deletion of chromosome 3 shown to cause developmental delay and congenital anomalies. Deletion is also seen along with FOXP1, EIF4E3 and PROK2 resulting in speech delay, contractures, hypertonia and blepharophimosis, although the physiological role (if any) of GPR27 is unknown [5-6].

References

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1. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. (2012) An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet., 8 (1): e1002449. [PMID:22253604]

2. Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, Lipska BK, Weinberger DR, Kleinman JE. (2005) A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Res. Mol. Brain Res., 138 (1): 58-69. [PMID:15893849]

3. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K. (2000) An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem. Biophys. Res. Commun., 272 (2): 576-82. [PMID:10833454]

4. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR. (1998) Discovery of three novel G-protein-coupled receptor genes. Genomics, 47: 310-313. [PMID:9479505]

5. Pariani MJ, Spencer A, Graham JM, Rimoin DL. (2009) A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. Eur J Med Genet, 52 (2-3): 123-7. [PMID:19332160]

6. Petek E, Windpassinger C, Simma B, Mueller T, Wagner K, Kroisel PM. (2003) Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies. J. Hum. Genet., 48 (6): 283-7. [PMID:12836054]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR27. Last modified on 31/07/2015. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=97.