Na-Cl symporter

Nomenclature: Na-Cl symporter

Abbreviated Name: NCC

Systematic Nomenclature: SLC12A3

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1021 16q13 SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
Mouse - 1002 8 46.46 cM Slc12a3 solute carrier family 12, member 3
Rat - 1002 19p14-p12 Slc12a3 solute carrier family 12 (sodium/chloride transporter), member 3
Previous and Unofficial Names
Thiazide-sensitive sodium-chloride cotransporter
TSC
NCCT
NCC
solute carrier family 12 member 3
solute carrier family 12, member 3
thiazide-sensitive Na-Cl cotransporter
solute carrier family 12 (sodium/chloride transporters), member 3
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PhosphoSitePlus
TreeFam
UniProtKB
Stoichiometry
1 Na+ : 1 Cl- (in)
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
hydrochlorothiazide Hs Inhibition - -
chlorothiazide Hs Inhibition - -
cyclothiazide Hs Inhibition - -
metolazone Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Gitelman syndrome
OMIM:  263800
Orphanet:  358
References: 
Mutations not determined

How to cite this page

SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 21/03/2014. Accessed on 02/08/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=970.