Na-Cl symporter

Target id: 970

Nomenclature: Na-Cl symporter

Abbreviated Name: NCC

Systematic Nomenclature: SLC12A3

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1021 16q13 SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1
Mouse - 1002 8 46.46 cM Slc12a3 solute carrier family 12, member 3
Rat - 1002 19p14-p12 Slc12a3 solute carrier family 12 (sodium/chloride transporter), member 3
Previous and Unofficial Names
Thiazide-sensitive sodium-chloride cotransporter
TSC
NCCT
solute carrier family 12 (sodium/chloride transporters), member 3
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PhosphoSitePlus
TreeFam
UniProtKB
Stoichiometry
1 Na+ : 1 Cl- (in)
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
hydrochlorothiazide Hs Inhibition - -
chlorothiazide Hs Inhibition - -
cyclothiazide Hs Inhibition - -
metolazone Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Gitelman syndrome
OMIM:  263800
Orphanet:  358
References:  2

References

Show »

1. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. (1996) Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics35 (3): 486-93. [PMID:8812482]

2. Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G. (2004) Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am. J. Physiol. Renal Physiol.287 (2): F195-203. [PMID:15068971]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 18/07/2014. Accessed on 22/12/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=970.