Na-Cl symporter

Target id: 970

Nomenclature: Na-Cl symporter

Abbreviated Name: NCC

Systematic Nomenclature: SLC12A3

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Na-Cl symporter in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1021 16q13 SLC12A3 solute carrier family 12 member 3 1
Mouse - 1002 8 46.46 cM Slc12a3 solute carrier family 12, member 3
Rat - 1002 19p14-p12 Slc12a3 solute carrier family 12 member 3
Previous and Unofficial Names
Thiazide-sensitive sodium-chloride cotransporter | TSC | NCCT | solute carrier family 12 (sodium/chloride transporters), member 3 | solute carrier family 12 (sodium/chloride transporter), member 3
Database Links
Specialist databases
Bioparadigms SLC Tables SLC12A3 (Hs)
Other databases
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Stoichiometry
1 Na+ : 1 Cl- (in)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cyclothiazide Hs Inhibition - -
chlorothiazide Hs Inhibition - -
hydrochlorothiazide Hs Inhibition - -
metolazone Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Gitelman syndrome
Disease Ontology: DOID:0050450
OMIM: 263800
Orphanet: ORPHA358
References:  2

References

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1. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. (1996) Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics35 (3): 486-93. [PMID:8812482]

2. Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G. (2004) Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am. J. Physiol. Renal Physiol.287 (2): F195-203. [PMID:15068971]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 01/04/2015. Accessed on 24/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=970.