target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id M1 receptor,13,P11229,Human,clozapine,38,,135398737,CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2,"InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3",QZUDBNBUXVUHMW-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pIC50,,7.9,,,,,,,,,,14595031, M1 receptor,13,P08482,Rat,clozapine,38,,135398737,CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2,"InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3",QZUDBNBUXVUHMW-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pIC50,,7.7,,,,,,,,,,16959945, M1 receptor,13,P11229,Human,xanomeline,57,,60809,CCCCCCOc1nsnc1C1=CCCN(C1)C,"InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3",JOLJIIDDOBNFHW-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,7.9,,6.7,,,,,=,,,,9884068|9614217|10323594|36782010, M1 receptor,13,P11229,Human,amitriptyline,200,,2160,CN(CCC=C1c2ccccc2CCc2c1cccc2)C,"InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3",KRMDCWKBEZIMAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,7.83,,Ki,,14.7,,=,,,,8100134, M1 receptor,13,P11229,Human,(±)YM796,285,,177233,CN1CCC2(CC1)CC(=C)C(O2)C,"InChI=1S/C11H19NO/c1-9-8-11(13-10(9)2)4-6-12(3)7-5-11/h10H,1,4-8H2,2-3H3",HDTOQYUZMCNTBZ-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,4.7,,4.1,,,,,,,,,1310135, M1 receptor,13,P11229,Human,(+)-aceclidine,286,,6954180,CC(=O)O[C@@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m1/s1",WRJPSSPFHGNBMG-SECBINFHSA-O,Agonist,Full agonist,,,,,pEC50,,5.4,,,,,,,,,,8968358, M1 receptor,13,P11229,Human,(-)-YM796,287,,10313386,CN1CCC2(CC1)CC(=C)[C@H](O2)C,"InChI=1S/C11H19NO/c1-9-8-11(13-10(9)2)4-6-12(3)7-5-11/h10H,1,4-8H2,2-3H3/t10-/m1/s1",HDTOQYUZMCNTBZ-SNVBAGLBSA-N,Agonist,Partial agonist,,,,,pKi,4.8,,4.3,,,,,,,,,1310135, M1 receptor,13,P11229,Human,(-)-aceclidine,288,,6979053,CC(=O)O[C@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m0/s1",WRJPSSPFHGNBMG-VIFPVBQESA-O,Agonist,Partial agonist,,,,,pEC50,,5.0,,,,,,,,,,8968358, M1 receptor,13,P11229,Human,AC-42,289,,9948320,CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C,"InChI=1S/C20H31NO/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3",ANTKBACNWQHQJE-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.2,,,,,,,,,,16207821, M1 receptor,13,P11229,Human,AC-42,289,,9948320,CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C,"InChI=1S/C20H31NO/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3",ANTKBACNWQHQJE-UHFFFAOYSA-N,Allosteric modulator,Negative,,,,,pKi,,6.2,,,,,,,,,,16207821, M1 receptor,13,P11229,Human,McN-A-343,290,,5926,O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-],"InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H",CXFZFEJJLNLOTA-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,5.2,,4.8,,,,,,,,,7620715, M1 receptor,13,P08482,Rat,McN-A-343,290,,5926,O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-],"InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H",CXFZFEJJLNLOTA-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,5.1,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,NNC 11-1314,291,,10426487,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1,"InChI=1S/C18H19N3OS/c1-2-5-14(6-3-1)7-4-12-22-18-17(19-23-20-18)16-13-21-10-8-15(16)9-11-21/h1-3,5-6,15-16H,8-13H2",SNSMIIQEKVYNOH-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,7.4,,,,,,,,,,11504829, M1 receptor,13,P11229,Human,NNC 11-1585,292,,11757797,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1(17-37-29-27(31-39-33-29)25-19-35-13-9-23(25)10-14-35)3-21-5-7-22(8-6-21)4-2-18-38-30-28(32-40-34-30)26-20-36-15-11-24(26)12-16-36/h5-8,23-26H,9-20H2",ROEXPZFFOZZHOY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.9,,,,,,,,,,11504829, M1 receptor,13,P11229,Human,NNC 11-1607,293,,9985526,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1-4-21(6-2-16-37-29-27(31-39-33-29)25-19-35-12-8-23(25)9-13-35)18-22(5-1)7-3-17-38-30-28(32-40-34-30)26-20-36-14-10-24(26)11-15-36/h1,4-5,18,23-26H,8-17,19-20H2",TYLFZULSDOOCRC-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.6,,,,,,,,,,11504829, M1 receptor,13,P11229,Human,acetylcholine,294,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Full agonist,,yes,,,pKi,4.9,,4.3,,,,,=,,,,9224827|23798605, M1 receptor,13,P08482,Rat,acetylcholine,294,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Full agonist,,yes,,,pKi,,5.0,,,,,,,,,,12235229, M1 receptor,13,P11229,Human,arecaidine propargyl ester,295,,2229,CN1CC(=CCC1)C(=O)OCC#C,"InChI=1S/C10H13NO2/c1-3-7-13-10(12)9-5-4-6-11(2)8-9/h1,5H,4,6-8H2,2H3",SPHRJZBOFYIKMC-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.4,,,,,,=,,,,9224827, M1 receptor,13,P11229,Human,arecoline,296,,2230,COC(=O)C1=CCCN(C1)C,"InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3",HJJPJSXJAXAIPN-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.7,,,,,,=,,,,7620715|9224827|32717485, M1 receptor,13,P08482,Rat,arecoline,296,,2230,COC(=O)C1=CCCN(C1)C,"InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3",HJJPJSXJAXAIPN-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,5.3,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,bethanechol,297,,2370,CC(C[N+](C)(C)C)OC(=O)N,"InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1",NZUPCNDJBJXXRF-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,,4.0,,,,,,=,,,,7620715|9224827, M1 receptor,13,P08482,Rat,bethanechol,297,,2370,CC(C[N+](C)(C)C)OC(=O)N,"InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1",NZUPCNDJBJXXRF-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,,3.7,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,carbachol,298,,2551,NC(=O)OCC[N+](C)(C)C,"InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1",VPJXQGSRWJZDOB-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,5.3,,3.2,,,,,=,,,,9224827|9614217|10323594, M1 receptor,13,P08482,Rat,carbachol,298,,2551,NC(=O)OCC[N+](C)(C)C,"InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1",VPJXQGSRWJZDOB-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,,3.9,,,,,,,,,,12235229, M1 receptor,13,P11229,Human,furtrethonium,299,,10938,C[N+](Cc1ccco1)(C)C,"InChI=1S/C8H14NO/c1-9(2,3)7-8-5-4-6-10-8/h4-6H,7H2,1-3H3/q+1",HEDXEAAVEOJUCR-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,4.1,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,methylfurmethide,300,,4141,Cc1ccc(o1)C[N+](C)(C)C,"InChI=1S/C9H16NO/c1-8-5-6-9(11-8)7-10(2,3)4/h5-6H,7H2,1-4H3/q+1",KOWVJDFMEZKDDT-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,4.6,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,milameline,301,,9571002,CO/N=C/C1=CCCN(C1)C,"InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+",YMMXHEYLRHNXAB-RMKNXTFCSA-N,Agonist,Partial agonist,,,,,pKi,,4.8,,,,,,,,,,10323594, M1 receptor,13,P11229,Human,oxotremorine,302,,4630,O=C1CCCN1CC#CCN1CCCC1,"InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2",RSDOPYMFZBJHRL-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,5.5,,,,,,=,,,,7620715|9224827, M1 receptor,13,P08482,Rat,oxotremorine,302,,4630,O=C1CCCN1CC#CCN1CCCC1,"InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2",RSDOPYMFZBJHRL-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,6.0,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,oxotremorine-M,303,,4629,O=C1CCCN1CC#CC[N+](C)(C)C,"InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1",CANZROMYQDHYHR-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.1,,,,,,=,,,,9224827, M1 receptor,13,P08482,Rat,oxotremorine-M,303,,4629,O=C1CCCN1CC#CC[N+](C)(C)C,"InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1",CANZROMYQDHYHR-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.6,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,pentylthio-TZTP,304,,10062394,CCCCCSc1nsnc1C1=CCCN(C1)C,"InChI=1S/C13H21N3S2/c1-3-4-5-9-17-13-12(14-18-15-13)11-7-6-8-16(2)10-11/h7H,3-6,8-10H2,1-2H3",LRTWCQHCJKYNPS-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.6,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,pilocarpine,305,,5910,CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C,"InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1",QCHFTSOMWOSFHM-WPRPVWTQSA-N,Agonist,Partial agonist,,,,,pKi,,5.1,,,,,,=,,,,7620715|9224827, M1 receptor,13,P08482,Rat,pilocarpine,305,,5910,CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C,"InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1",QCHFTSOMWOSFHM-WPRPVWTQSA-N,Agonist,Partial agonist,,,,,pKi,,4.9,,,,,,,,,,2537406, M1 receptor,13,P11229,Human,sabcomeline,306,,9577995,CO/N=C(/[C@H]1CN2CCC1CC2)\C#N,"InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+/t9-/m0/s1",IQWCBYSUUOFOMF-QTLFRQQHSA-N,Agonist,Partial agonist,,,,,pKi,,6.7,,,,,,,,,,10323594, M1 receptor,13,P11229,Human,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.3,,,,,,=,,,,1994002, M1 receptor,13,P08482,Rat,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.9,,,,,,,,,,1325587, M1 receptor,13,P11229,Human,p-F-HHSiD,308,,3603,Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O,"InChI=1S/C20H32FNOSi/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22/h10-13,19,23H,1-9,14-17H2",ZNSZQJHTFRQUPD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.8,,7.1,,,,,,,,,12049493|8759038, M1 receptor,13,P11229,Human,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,6.2,,,,,,=,,,,8759038, M1 receptor,13,P08482,Rat,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.3,,5.9,,,,,,,,,1325587|2704370, M1 receptor,13,P11229,Human,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,,,,,8759038, M1 receptor,13,P08482,Rat,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.9,,7.4,,,,,,,,,1325587|2704370, M1 receptor,13,P11229,Human,muscarinic toxin 1,311,,,,,,Antagonist,Antagonist,,,,,pKi,7.6,,7.3,,,,,,,,,12512959|16439611, M1 receptor,13,P11229,Human,muscarinic toxin 2,312,,,,,,Antagonist,Antagonist,,,,,pKi,,6.4,,,,,,,,,,12512959, M1 receptor,13,P11229,Human,muscarinic toxin 3,313,,,,,,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,=,,,,7925952, M1 receptor,13,P11229,Human,muscarinic toxin 7,314,,,,,,Allosteric modulator,Negative,,,,,pKi,11.1,,11.0,,,,,=,,,,16439611|10799315|11015294, M1 receptor,13,P11229,Human,N-methyl scopolamine,316,,71183,OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12?,13-,14-,15+,16-,17+/m1/s1",LZCOQTDXKCNBEE-XJMZPCNVSA-N,Antagonist,Antagonist,,,yes,,pKi,,9.9,,,,,,=,,,,16439611, M1 receptor,13,P11229,Human,[3H]N-methyl scopolamine,317,,71183,OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12?,13-,14-,15+,16-,17+/m1/s1",LZCOQTDXKCNBEE-XJMZPCNVSA-N,Antagonist,Antagonist,,,,,pKd,10.3,,9.4,Kd,0.42,,0.05,=,,,,9846649|9614217|11578621|11303071|9224827|16675658|7925952|16369696|7651370, M1 receptor,13,P08482,Rat,[3H]N-methyl scopolamine,317,,71183,OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12?,13-,14-,15+,16-,17+/m1/s1",LZCOQTDXKCNBEE-XJMZPCNVSA-N,Antagonist,Antagonist,,,,,pKd,,9.7,,,,,,,,,,7687290|12235229, M1 receptor,13,P11229,Human,[3H]QNB,318,,23056,O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2,"InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2",HGMITUYOCPPQLE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,10.8,,10.6,Kd,0.0251,,0.0158,=,,,,3443095|7562472, M1 receptor,13,P11229,Human,[3H]darifenacin,319,,444031,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2,"InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1",HXGBXQDTNZMWGS-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pKd,,8.8,,,,,,=,,,,9029489, M1 receptor,13,P11229,Human,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,yes,,pKi,9.6,,8.5,,,,,=,,,,3443095|9614217|12049493|16439611|11303071|9029489, M1 receptor,13,P08482,Rat,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,,,pKi,9.7,,9.0,,,,,,,,,12235229|1325587|2704370, M1 receptor,13,P11229,Human,darifenacin,321,,444031,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2,"InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1",HXGBXQDTNZMWGS-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pKi,9.1,,8.9,,,,,=,,,,11303071|20590605|9671109, M1 receptor,13,P08482,Rat,hexahydrodifenidol,322,,124226,OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C21H33NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1,4-5,11-12,20,23H,2-3,6-10,13-18H2",ILHSFCNKNNNPRN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.0,,,,,,,,,,2704370, M1 receptor,13,P08482,Rat,hexocyclium,323,,24199,C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O,"InChI=1S/C20H33N2O/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3/q+1",ZRYHPQCHHOKSMD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.6,,,,,,,,,,2704370, M1 receptor,13,P11229,Human,himbacine,324,,6436265,C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2,"InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1",FMPNFDSPHNUFOS-LPJDIUFZSA-N,Antagonist,Antagonist,,,,,pKi,7.1,,6.7,,,,,=,,,,7925952|1331410|1994002, M1 receptor,13,P11229,Human,ipratropium,325,,3746,OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C,"InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1",OEXHQOGQTVQTAT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.8,,9.3,,,,,=,,,,11303071|19653626, M1 receptor,13,P08482,Rat,lithocholylcholine,326,,22991950,OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C,"InChI=1S/C29H54NO2/c1-20(8-7-9-23(32)19-30(4,5)6)25-12-13-26-24-11-10-21-18-22(31)14-16-28(21,2)27(24)15-17-29(25,26)3/h20-27,31-32H,7-19H2,1-6H3/q+1",KWEWGNPMETZMTR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.6,,,,,,,,,,12235229, M1 receptor,13,P11229,Human,methoctramine,327,,4108,COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC,"InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3",RPMBYDYUVKEZJA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.3,,6.6,,,,,=,,,,8759038|9029489|1994002|9113359, M1 receptor,13,P08482,Rat,methoctramine,327,,4108,COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC,"InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3",RPMBYDYUVKEZJA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.8,,,,,,,,,,2704370, M1 receptor,13,P11229,Human,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,8.3,,7.6,,,,,=,,,,12049493|2704370|7925952|1994002|9113359|2043926, M1 receptor,13,P08482,Rat,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.9,,7.8,,,,,,,,,1325587|2704370, M1 receptor,13,P11229,Human,propantheline,329,,4934,O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C,"InChI=1S/C23H30NO3/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22/h6-13,16-17,22H,14-15H2,1-5H3/q+1",VVWYOYDLCMFIEM-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,9.7,,,,,,=,,,,12049493, M1 receptor,13,P11229,Human,scopolamine,330,,3000322,OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C,"InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1",STECJAGHUSJQJN-FWXGHANASA-N,Antagonist,Antagonist,,,yes,,pKi,,9.0,,,,,,=,,,,12049493|27085897, M1 receptor,13,P08482,Rat,silahexocyclium,331,,130169,C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O,"InChI=1S/C19H33N2OSi/c1-21(2)15-13-20(14-16-21)17-23(22,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,22H,4,7-8,11-17H2,1-2H3/q+1",GBISIIAKUATURW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.7,,,,,,,,,,2704370, M1 receptor,13,P11229,Human,N-benzyl brucine,332,,44358893,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1,"InChI=1S/C30H33N2O4/c1-34-23-13-21-22(14-24(23)35-2)31-27(33)15-25-28-20-12-26-30(21,29(28)31)9-10-32(26,17-19(20)8-11-36-25)16-18-6-4-3-5-7-18/h3-8,13-14,20,25-26,28-29H,9-12,15-17H2,1-2H3/q+1/t20-,25-,26-,28-,29-,30+,32?/m0/s1",XFMQETLKDRNYRE-QIBSSCBHSA-N,Allosteric modulator,Negative,,,,,pKd,,4.4,,,,,,,,,,9495826, M1 receptor,13,P11229,Human,N-desmethylclozapine,333,,135409468,Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1,"InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2",HESZUPIXRNZIOI-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pIC50,,7.3,,,,,,,,,,14595031, M1 receptor,13,P08482,Rat,N-desmethylclozapine,333,,135409468,Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1,"InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2",HESZUPIXRNZIOI-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pIC50,,6.8,,,,,,,,,,16959945, M1 receptor,13,P08482,Rat,AC-260584,334,,9928284,CCCCC1CCN(CC1)CCCN1C(=O)COc2c1ccc(c2)F,"InChI=1S/C20H29FN2O2/c1-2-3-5-16-8-12-22(13-9-16)10-4-11-23-18-7-6-17(21)14-19(18)25-15-20(23)24/h6-7,14,16H,2-5,8-13,15H2,1H3",BWAKMLKESHKOHK-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pIC50,,5.9,,,,,,,,,,16959945, M1 receptor,13,P11229,Human,Gö 7874,335,,3500,COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1,"InChI=1S/C27H26N4O4/c1-29(2)12-14(32)13-31-19-10-9-15(35-4)11-17(19)21-23-22(26(33)28-27(23)34)20-16-7-5-6-8-18(16)30(3)24(20)25(21)31/h5-11,14,32H,12-13H2,1-4H3,(H,28,33,34)",NYBAPNLYWRMTJL-UHFFFAOYSA-N,Allosteric modulator,Negative,,,,,pKd,,5.8,,,,,,,,,,10860942, M1 receptor,13,P11229,Human,K-252a,336,,490561,COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m0/s1",KOZFSFOOLUUIGY-IYYJOCMQSA-N,Allosteric modulator,Positive,,,,,pKd,,5.1,,,,,,,,,,10860942, M1 receptor,13,P11229,Human,KT 5720,337,,16219545,CCCCCCOC(=O)[C@@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1",ZHEHVZXPFVXKEY-IKZDWWSZSA-N,Allosteric modulator,Positive,,,,,pKd,,6.4,,Kd,,398.0,,=,,,,10860942, M1 receptor,13,P11229,Human,KT 5823,338,,108152,COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C,"InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1",QTYMDECKVKSGSM-YMUMJAELSA-N,Allosteric modulator,Positive,,,,,pKd,,5.7,,,,,,,,,,10860942, M1 receptor,13,P11229,Human,"WIN 51,708",339,,9803245,C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1,"InChI=1S/C29H33N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,17,19-22,33H,9-16H2,2-3H3/t19-,20+,21-,22-,27-,28-,29-/m0/s1",AIIXYCDTEGICEE-HZVAOYAWSA-N,Allosteric modulator,Negative,,,,,pKd,,5.8,,,,,,,,,,12435818, M1 receptor,13,P11229,Human,"WIN 62,577",340,,15118529,C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2,"InChI=1S/C29H31N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,15,17,20-22,33H,9-14,16H2,2-3H3/t20-,21+,22+,27+,28+,29+/m1/s1",YBCYJDNOPAFFOW-XOAARHKISA-N,Allosteric modulator,Negative,,,,,pKd,,5.5,,,,,,,,,,12435818, M1 receptor,13,P11229,Human,alcuronium,341,,5311001,C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C,"InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13?,30-14?,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47?,48?/m0/s1",MUQUYTSLDVKIOF-NCQXAQDZSA-N,Allosteric modulator,Negative,,,,,pKd,,5.0,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,brucine,342,,442021,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2,"InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1",RRKTZKIUPZVBMF-IBTVXLQLSA-N,Allosteric modulator,Neutral,,,,,pKd,,4.5,,,,,,=,,,,9495826, M1 receptor,13,P11229,Human,brucine,342,,442021,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2,"InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1",RRKTZKIUPZVBMF-IBTVXLQLSA-N,Allosteric modulator,Positive,,,,,pKd,5.8,,4.5,Kd,30000.0,,1780.0,=,,,,10101037|9224827|9495826, M1 receptor,13,P11229,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Neutral,,,,,pKd,,3.2,,,,,,,,,,9495826, M1 receptor,13,P11229,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Positive,,,,,pKd,,3.2,,,,,,=,,,,9495826, M1 receptor,13,P11229,Human,N-chloromethyl-brucine,344,,44358908,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl,"InChI=1S/C24H28ClN2O4/c1-29-17-8-15-16(9-18(17)30-2)26-21(28)10-19-22-14-7-20-24(15,23(22)26)4-5-27(20,12-25)11-13(14)3-6-31-19/h3,8-9,14,19-20,22-23H,4-7,10-12H2,1-2H3/q+1/t14-,19-,20-,22-,23-,24+,27?/m0/s1",GCEPQLWZBVGLQN-CQIPDZJVSA-N,Allosteric modulator,Negative,,,,,pKd,,4.1,,,,,,,,,,9495826, M1 receptor,13,P11229,Human,vinburnine,345,,71203,CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1,"InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1",WYJAPUKIYAZSEM-MOPGFXCFSA-N,Allosteric modulator,Neutral,,,,,pKd,,5.1,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,staurosporine,346,,44259,CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1",HKSZLNNOFSGOKW-FYTWVXJKSA-N,Allosteric modulator,Positive,,,,,pKd,,5.9,,,,,,,,,,10860942, M1 receptor,13,P11229,Human,strychnine,347,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Allosteric modulator,Negative,,,,,pKd,,4.9,,,,,,,,,,7651370, M1 receptor,13,P11229,Human,strychnine,347,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Allosteric modulator,Neutral,,,,,pKd,5.0,,4.9,,,,,,,,,7651370|9224827, M1 receptor,13,P11229,Human,thiochrome,348,,66706,OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C,"InChI=1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3",GTQXMAIXVFLYKF-UHFFFAOYSA-N,Allosteric modulator,Neutral,,,,,pKd,,4.1,,,,,,,,,,14722259, M1 receptor,13,P11229,Human,vincamine,349,,15376,COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3,"InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1",RXPRRQLKFXBCSJ-GIVPXCGWSA-N,Allosteric modulator,Neutral,,,,,pKd,,4.8,,,,,,,,,,9224827, M1 receptor,13,P11229,Human,dicyclomine,355,,3042,CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC,"InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3",CURUTKGFNZGFSE-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,9.08,,Ki,,0.83,,=,,,,, M1 receptor,13,P11229,Human,oxybutynin,359,,4634,CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC,"InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3",XIQVNETUBQGFHX-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,8.6,,Ki,,2.4,,=,,,,22243489|20590605, M1 receptor,13,P08482,Rat,oxybutynin,359,,4634,CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC,"InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3",XIQVNETUBQGFHX-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.2,,,,,,=,,,,16220976, M1 receptor,13,P11229,Human,tolterodine,360,,443879,Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O,"InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1",OOGJQPCLVADCPB-HXUWFJFHSA-N,Antagonist,Antagonist,,,,,pKi,8.5,,8.4,,,,,=,,,,20590605|9671109, M1 receptor,13,P11229,Human,tripitramine,361,,132947,CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C,"InChI=1S/C64H77N13O6/c1-72(41-20-8-5-17-35-65-44-56(78)75-53-32-14-11-26-47(53)62(81)69-50-29-23-36-66-59(50)75)39-18-6-3-4-7-19-40-73(2)42-21-9-10-22-43-74(45-57(79)76-54-33-15-12-27-48(54)63(82)70-51-30-24-37-67-60(51)76)46-58(80)77-55-34-16-13-28-49(55)64(83)71-52-31-25-38-68-61(52)77/h11-16,23-34,36-38,65H,3-10,17-22,35,39-46H2,1-2H3,(H,69,81)(H,70,82)(H,71,83)",YUJOQEAGGUIMED-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.8,,,,,,=,,,,7805774, M1 receptor,13,P11229,Human,tiotropium,367,,5487427,O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17+",LERNTVKEWCAPOY-FPISHFTHSA-N,Antagonist,Antagonist,,,,,pKi,10.7,,9.6,,,,,=,,,,19653626|8441333|22854200|21036042, M1 receptor,13,P11229,Human,VU0090157,3259,,2882724,O=C1NC(C(=C(N1C)C)C(=O)OC1CCCC1)c1cc2OCOc2cc1[N+](=O)[O-],"InChI=1S/C19H21N3O7/c1-10-16(18(23)29-11-5-3-4-6-11)17(20-19(24)21(10)2)12-7-14-15(28-9-27-14)8-13(12)22(25)26/h7-8,11,17H,3-6,9H2,1-2H3,(H,20,24)",GUFKDOZSNUQIAS-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,19047481, M1 receptor,13,P11229,Human,VU0029767,3261,,135867898,CCOc1ccc(cc1)NCC(=O)N/N=C/c1c(O)ccc2c1cccc2,"InChI=1S/C21H21N3O3/c1-2-27-17-10-8-16(9-11-17)22-14-21(26)24-23-13-19-18-6-4-3-5-15(18)7-12-20(19)25/h3-13,22,25H,2,14H2,1H3,(H,24,26)/b23-13+",JWRJGCUSLSJMMD-YDZHTSKRSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,19047481, M1 receptor,13,P11229,Human,AFDX384,3264,,119357,CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC,"InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)",MZDYABXXPZNUCT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.5,,,,,,=,,,,1994002, M1 receptor,13,P11229,Human,[11C]butylthio-TZTP,3268,,73755038,[11CH3]CCCSc1nsnc1C1=CCCN(C1)C,"InChI=1S/C12H19N3S2/c1-3-4-8-16-12-11(13-17-14-12)10-6-5-7-15(2)9-10/h6H,3-5,7-9H2,1-2H3/i1-1",SFXHHGRYNXLPKT-BJUDXGSMSA-N,Agonist,Full agonist,,,,,,,,,,,,,=,,,,8835881, M1 receptor,13,P11229,Human,[3H]pirenzepine,3272,,53325462,O=C(n1c2ccccc2c(=O)[nH]c2c1nccc2)CN1CCN(CC1)C([3H])([3H])[3H],"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/i1T3",RMHMFHUVIITRHF-RLXJOQACSA-N,Antagonist,Antagonist,,,,,pKd,,7.9,,Kd,,14.0,,=,,,,6546354|18957051|29515448|32079174, M1 receptor,13,P08482,Rat,[3H]pirenzepine,3272,,53325462,O=C(n1c2ccccc2c(=O)[nH]c2c1nccc2)CN1CCN(CC1)C([3H])([3H])[3H],"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/i1T3",RMHMFHUVIITRHF-RLXJOQACSA-N,Antagonist,Antagonist,,,,,pKd,7.9,,7.7,,,,,=,,,,2704371|7350532, M1 receptor,13,P11229,Human,VU0255035,3274,,24768606,O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2,"InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2",WXDHQWPQLKGANZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.8,,Ki,,14.87,,=,,,,19407080, M1 receptor,13,P08482,Rat,"[18F](R,R)-quinuclidinyl-4-fluoromethyl-benzilate",3275,,73755039,[18F]Cc1ccc(cc1)[C@](c1ccccc1)(C(=O)O[C@H]1CN2CCC1CC2)O,"InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20-,22+/m0/s1/i23-1",WYNSCFORRAXQPA-IFWCHYDGSA-N,Antagonist,Antagonist,,,,,,,,,,,,,=,,,,9313861, M1 receptor,13,P08482,Rat,guanylpirenzepine,3276,,129786,NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N7O2/c20-19(21)25-10-8-24(9-11-25)12-16(27)26-15-6-2-1-4-13(15)18(28)23-14-5-3-7-22-17(14)26/h1-7H,8-12H2,(H3,20,21)(H,23,28)",YGBQWISDDSXPRF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.6,,7.3,,,,,=,,,,8813552|10323493, M1 receptor,13,P11229,Human,[11C]xanomeline,3278,,73755040,CCCCCCOc1nsnc1C1=CCCN(C1)[11CH3],"InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3/i2-1",JOLJIIDDOBNFHW-JVVVGQRLSA-N,Agonist,Full agonist,,,,,,,,,,,,,=,,,,8835881, M1 receptor,13,P11229,Human,BQCA,5436,,17865255,OC(=O)c1c(=O)[nH]c2c(c1Cc1ccccc1)cccc2,"InChI=1S/C17H13NO3/c19-16-15(17(20)21)13(10-11-6-2-1-3-7-11)12-8-4-5-9-14(12)18-16/h1-9H,10H2,(H,18,19)(H,20,21)",LPQIYUCWQOQFCS-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKB,4.8,,4.0,,,,,=,,,,19717450|22086918|24443568|25326383, M1 receptor,13,P11229,Human,ML169,5437,,44475955,Brc1ccc(c(c1)Cn1cc(c2c1cccc2)S(=O)(=O)CC(=O)Nc1noc(c1)C)F,"InChI=1S/C21H17BrFN3O4S/c1-13-8-20(25-30-13)24-21(27)12-31(28,29)19-11-26(18-5-3-2-4-16(18)19)10-14-9-15(22)6-7-17(14)23/h2-9,11H,10,12H2,1H3,(H,24,25,27)",RUYRNYRGPSAXTK-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.9,,EC50,,1380.0,,=,,,,23173069, M1 receptor,13,P11229,Human,LY593093,5441,,9893054,O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C,"InChI=1S/C32H30FN3O2/c1-21(36(2)20-22-8-15-27(33)16-9-22)34-28-17-14-26-18-30(37)31(29(26)19-28)35-32(38)25-12-10-24(11-13-25)23-6-4-3-5-7-23/h3-17,19,30-31,37H,18,20H2,1-2H3,(H,35,38)/t30-,31-/m1/s1",KOQVBYSCBCRVQJ-FIRIVFDPSA-N,Agonist,Partial agonist,,,,,pKi,,6.21,,,,,,=,,,,21558436, M1 receptor,13,P12657,Mouse,tacrine,6687,,1935,Nc1c2CCCCc2nc2c1cccc2,"InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)",YLJREFDVOIBQDA-UHFFFAOYSA-N,Allosteric modulator,Negative,,,,,pIC50,,5.7,,IC50,,2000.0,,=,,,,1552502, M1 receptor,13,P11229,Human,iperoxo,6937,,10104167,C[N+](CC#CCOC1=NOCC1)(C)C,"InChI=1S/C10H17N2O2/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10/h6-9H2,1-3H3/q+1",WXXOCGISBCTWPW-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,24863257, M1 receptor,13,P11229,Human,biperiden,7128,,2381,OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1,"InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2",YSXKPIUOCJLQIE-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKd,,9.32,,Kd,,0.48,,=,,,,1346637, M1 receptor,13,P08482,Rat,ethopropazine,7181,,3290,CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC,"InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3",CDOZDBSBBXSXLB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.51,,Ki,,3.1,,=,Displacement of [H]QNB binding in rat forebrain brain homogenate.,,,2904117, M1 receptor,13,P11229,Human,trihexyphenidyl,7315,,5572,OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1,"InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2",HWHLPVGTWGOCJO-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,8.87,,Ki,,1.35,,=,,,,, M1 receptor,13,P11229,Human,umeclidinium,7354,,11519070,OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1,"InChI=1S/C29H34NO2/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25/h1-15,31H,16-24H2/q+1",FVTWTVQXNAJTQP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.8,,Ki,,0.16,,=,,,,19317446|23435542, M1 receptor,13,P11229,Human,droxidopa,7391,,92974,OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N,"InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1",QXWYKJLNLSIPIN-JGVFFNPUSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,=,,,,27085897, M1 receptor,13,P08482,Rat,methacholine,7438,,1993,CC(C[N+](C)(C)C)OC(=O)C,"InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1",NZWOPGCLSHLLPA-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,6.4,,EC50,,400.0,,=,,,,7620715|9622546, M1 receptor,13,P11229,Human,aclidinium,7449,,11434515,O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2,"InChI=1S/C26H30NO4S2/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1",ASMXXROZKSBQIH-VITNCHFBSA-N,Antagonist,Antagonist,,,,,pIC50,10.2,,10.1,IC50,,,,=,,,,19653626|21036042, M1 receptor,13,P11229,Human,glycopyrrolate,7459,,3494,O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C,"InChI=1S/C19H28NO3/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3/q+1",ANGKOCUUWGHLCE-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pIC50,10.1,,9.6,IC50,,,,=,Assay uses glycopyrronium bromide,,,21036043|22854200, M1 receptor,13,P11229,Human,solifenacin,7483,,154059,O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2,"InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1",FBOUYBDGKBSUES-VXKWHMMOSA-N,Antagonist,Antagonist,,,,,pIC50,,7.2,,IC50,,63.5,,=,,,,21524581, M1 receptor,13,P11229,Human,solifenacin,7483,,154059,O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2,"InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1",FBOUYBDGKBSUES-VXKWHMMOSA-N,Antagonist,Antagonist,,,,,pKi,,7.6,,,,,,=,,,,12122494|20590605, M1 receptor,13,P08482,Rat,solifenacin,7483,,154059,O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2,"InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1",FBOUYBDGKBSUES-VXKWHMMOSA-N,Antagonist,Antagonist,,,,,pKi,,8.0,,,,,,=,,,,16220976, M1 receptor,13,P11229,Human,dosulepin,7549,,5282426,CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C,"InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11-",PHTUQLWOUWZIMZ-BOPFTXTBSA-N,Antagonist,Antagonist,,,,,pKi,,7.74,,Ki,,18.0,,=,,,,8100134, M1 receptor,13,P08482,Rat,benzatropine,7601,,1201549,CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1,"InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+",GIJXKZJWITVLHI-PMOLBWCYSA-N,Antagonist,Antagonist,,,,,pKi,,9.02,,Ki,,0.95,,=,Displacement binding experiment using homogenised rat caudate putamen.,,,7562926, M1 receptor,13,P11229,Human,VU0119498,7632,,3008304,Brc1ccc(cc1)CN1c2ccccc2C(=O)C1=O,"InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2",DELLOEULSHGYCG-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.2,,EC50,,6040.0,,=,,,,19438238, M1 receptor,13,P11229,Human,AZD6088,7822,,25195463,CCOC(=O)N1CCC(CC1)(C)N1CCC(CC1)N1C(=O)N[C@@H]2[C@@H]1CCCC2,"InChI=1S/C21H36N4O3/c1-3-28-20(27)23-14-10-21(2,11-15-23)24-12-8-16(9-13-24)25-18-7-5-4-6-17(18)22-19(25)26/h16-18H,3-15H2,1-2H3,(H,22,26)/t17-,18-/m0/s1",IVJDEIANCSDDAO-ROUUACIJSA-N,Agonist,Partial agonist,,,yes,,pEC50,,8.3,,EC50,,5.0,,=,,,,, M1 receptor,13,P11229,Human,benzoquinazolinone 12,8549,,46196414,O[C@H]1CCCC[C@@H]1n1cnc2c(c1=O)cc(c1c2cccc1)Cc1ccc(nc1)c1cnn(c1)C,"InChI=1S/C28H27N5O2/c1-32-16-20(15-31-32)24-11-10-18(14-29-24)12-19-13-23-27(22-7-3-2-6-21(19)22)30-17-33(28(23)35)25-8-4-5-9-26(25)34/h2-3,6-7,10-11,13-17,25-26,34H,4-5,8-9,12H2,1H3/t25-,26-/m0/s1",SXJQBWJPNSOKQV-UIOOFZCWSA-N,Allosteric modulator,Positive,,,,,pKB,,6.6,,,,,,=,,,,25326383, M1 receptor,13,P11229,Human,AQ-RA 741,8584,,129989,CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)",BCUGCHZRMKTPMU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.5,,7.2,,,,,=,,,,1994002|9671109, M1 receptor,13,P11229,Human,ML381,8591,,42519285,CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C,"InChI=1S/C21H21N3O4/c1-14(19-9-4-5-10-22-19)24(3)21(26)20-12-18(28-23-20)13-27-17-8-6-7-16(11-17)15(2)25/h4-12,14H,13H2,1-3H3/t14-/m0/s1",JMYDHMCYZKRDPD-AWEZNQCLSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,24692176, M1 receptor,13,P11229,Human,[3H]acetylcholine,8593,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, M1 receptor,13,P08482,Rat,[3H](+)telenzepine,8594,,5387,CN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2,"InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)",VSWPGAIWKHPTKX-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.4,,,,,,=,,,,2704371, M1 receptor,13,P11229,Human,Cy3B-telenzepine,8598,,91827377,O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2,"InChI=1S/C59H73N7O7S2/c1-38-54-43(37-74-38)57(69)61-46-16-12-13-17-49(46)66(54)53(68)36-63-30-28-62(29-31-63)25-15-11-9-7-6-8-10-14-24-60-52(67)33-39-18-20-47-44(32-39)58(2,3)55-41-35-42-51(73-50(41)22-26-64(47)55)23-27-65-48-21-19-40(75(70,71)72)34-45(48)59(4,5)56(42)65/h12-13,16-21,32,34-35,37,50-51H,6-11,14-15,22-31,33,36H2,1-5H3,(H4-,60,61,67,69,70,71,72)/p-2",DGPHRPUJPHDIPO-UHFFFAOYSA-L,Antagonist,Antagonist,,,,,pKd,,10.5,,,,,,=,,,,20133736, M1 receptor,13,P11229,Human,Alexa-488-telenzepine,8600,,91827379,O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2,"InChI=1S/C49H57N7O12S3/c1-29-42-35(28-69-29)48(59)53-38-12-8-9-13-39(38)56(42)40(57)27-55-24-22-54(23-25-55)21-11-7-5-3-2-4-6-10-20-52-47(58)30-14-15-31(34(26-30)49(60)61)41-32-16-18-36(50)45(70(62,63)64)43(32)68-44-33(41)17-19-37(51)46(44)71(65,66)67/h8-9,12-19,26,28,50,62-67H,2-7,10-11,20-25,27,51H2,1H3,(H,52,58)(H,53,59)(H,60,61)/p-6",SRLBGILQMKQWSJ-UHFFFAOYSA-H,Antagonist,Antagonist,,,,,pKd,,9.3,,,,,,=,,,,20133736, M1 receptor,13,P11229,Human,BODIPY-pirenzepine,8604,,101244456,O=C(CCc1ccc(n1B(F)F)/C=C/1\C=CC(=N1)c1cccs1)NCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C40H43BF2N8O3S/c42-41(43)51-30(14-15-31(51)27-29-13-17-33(46-29)36-12-8-26-55-36)16-18-37(52)44-19-5-1-2-6-21-48-22-24-49(25-23-48)28-38(53)50-35-11-4-3-9-32(35)40(54)47-34-10-7-20-45-39(34)50/h3-4,7-15,17,20,26-27H,1-2,5-6,16,18-19,21-25,28H2,(H,44,52)(H,47,54)/b29-27+",QGXCAYBSIKPOHP-ORIPQNMZSA-N,Antagonist,Antagonist,,,,,pKi,,7.0,,,,,,=,,,,19451648, M1 receptor,13,P11229,Human,PF-06767832,9228,,118663155,O[C@H]1COCC[C@@H]1NC(=O)c1ncc(c(c1)Cc1ccc(cc1)c1cscn1)C,"InChI=1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1",VVZZHFMLRHJXTO-RXVVDRJESA-N,Allosteric modulator,Positive,,,yes,,pEC50,,7.22,,EC50,,60.0,,=,FLIPR calcium mobilisation assay,,,27275946, M1 receptor,13,P11229,Human,cevimeline,9658,,2684,CC1SCC2(O1)CN1CCC2CC1,"InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3",WUTYZMFRCNBCHQ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.31,,Ki,,4850.0,,=,Displacement of [3H]QNB from cloned receptor.,,,9399977, M1 receptor,13,P11229,Human,(S)-dimetindene,10104,,6604866,CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C,"InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m1/s1",MVMQESMQSYOVGV-OAHLLOKOSA-N,Antagonist,Antagonist,,,,,pKi,,6.72,,Ki,,190.6,,=,Binding to hM1 receptors expressed in CHO cells.,,,12593665, M1 receptor,13,P11229,Human,revefenacin,10129,,11753673,O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C,"InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41)23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)",FYDWDCIFZSGNBU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.38,,Ki,,0.417,,=,"Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM1 receptor, and displacement of [3H]NMS tracer.",,,29736245, M1 receptor,13,,None,SPP1,10259,,137553163,Cc1cccc(c1)N1CN(C(=O)C21CCN(CC2)C1CCN(CC1)C(=O)OC1CC1)C,"InChI=1S/C24H34N4O3/c1-18-4-3-5-20(16-18)28-17-25(2)22(29)24(28)10-14-26(15-11-24)19-8-12-27(13-9-19)23(30)31-21-6-7-21/h3-5,16,19,21H,6-15,17H2,1-2H3",ZZZVRFJGTJAHFM-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,30276808, M1 receptor,13,P11229,Human,T‐495,10711,,124155515,O[C@H]1CCC[C@@H]1N1COc2c(C1=O)cc(c(c2Cl)C)Cc1ccc(nc1)Cl,"InChI=1S/C20H20Cl2N2O3/c1-11-13(7-12-5-6-17(21)23-9-12)8-14-19(18(11)22)27-10-24(20(14)26)15-3-2-4-16(15)25/h5-6,8-9,15-16,25H,2-4,7,10H2,1H3/t15-,16-/m0/s1",BWJHJLINOYAPEG-HOTGVXAUSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,31990455, M1 receptor,13,P11229,Human,MK-7622,10712,,46207733,O[C@H]1CCCC[C@@H]1n1cnc2c(c1=O)cc(c1c2cccc1)Cc1ccc(nc1)C,"InChI=1S/C25H25N3O2/c1-16-10-11-17(14-26-16)12-18-13-21-24(20-7-3-2-6-19(18)20)27-15-28(25(21)30)22-8-4-5-9-23(22)29/h2-3,6-7,10-11,13-15,22-23,29H,4-5,8-9,12H2,1H3/t22-,23-/m0/s1",JUVQLZBJFOGEEO-GOTSBHOMSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,30034595, M1 receptor,13,P11229,Human,T532,12303,,142503719,Cn1nnc(c1)c1ccc(cc1)Cc1c2c(nc(c1)C(=O)N[C@H]1CCOC[C@@H]1O)cco2,"InChI=1S/C23H23N5O4/c1-28-12-20(26-27-28)15-4-2-14(3-5-15)10-16-11-19(24-18-7-9-32-22(16)18)23(30)25-17-6-8-31-13-21(17)29/h2-5,7,9,11-12,17,21,29H,6,8,10,13H2,1H3,(H,25,30)/t17-,21-/m0/s1",KDAYHBHQHWHAOK-UWJYYQICSA-N,Allosteric modulator,Positive,,,,,pEC50,8.1,,8.0,EC50,10.0,,8.0,=,PAM potency determined in M1 receptor-expressing CHO cells,,,31374156, M1 receptor,13,P11229,Human,T440,12304,,153520922,Fc1cc(ccc1C(=O)NCCOC)Cc1cc2c(=O)n(cnc2c(c1C)C)[C@H]1CCOC[C@@H]1O,"InChI=1S/C26H30FN3O5/c1-15-16(2)24-20(26(33)30(14-29-24)22-6-8-35-13-23(22)31)12-18(15)10-17-4-5-19(21(27)11-17)25(32)28-7-9-34-3/h4-5,11-12,14,22-23,31H,6-10,13H2,1-3H3,(H,28,32)/t22-,23-/m0/s1",SNQCVLJLRXRTTJ-GOTSBHOMSA-N,Allosteric modulator,Positive,,,,,pEC50,,8.2,,EC50,,6.3,,=,Determined in CHO-K1 cells transfected with the human M1 receptor.,,,32337809, M1 receptor,13,P08482,Rat,T440,12304,,153520922,Fc1cc(ccc1C(=O)NCCOC)Cc1cc2c(=O)n(cnc2c(c1C)C)[C@H]1CCOC[C@@H]1O,"InChI=1S/C26H30FN3O5/c1-15-16(2)24-20(26(33)30(14-29-24)22-6-8-35-13-23(22)31)12-18(15)10-17-4-5-19(21(27)11-17)25(32)28-7-9-34-3/h4-5,11-12,14,22-23,31H,6-10,13H2,1-3H3,(H,28,32)/t22-,23-/m0/s1",SNQCVLJLRXRTTJ-GOTSBHOMSA-N,Allosteric modulator,Positive,,,,,pEC50,,8.23,,EC50,,5.9,,=,,,,32337809, M1 receptor,13,P11229,Human,VU0486846,12305,,118124117,C1CC[C@@H]([C@H](C1)NC(=O)[C@H]1CN(c2ccccc2O1)Cc1ccc(cc1)n1cccn1)O,"InChI=1S/C25H28N4O3/c30-22-8-3-1-6-20(22)27-25(31)24-17-28(21-7-2-4-9-23(21)32-24)16-18-10-12-19(13-11-18)29-15-5-14-26-29/h2,4-5,7,9-15,20,22,24,30H,1,3,6,8,16-17H2,(H,27,31)/t20-,22-,24+/m0/s1",LZCHTDQRMCSDSE-ODGPQVTHSA-N,Allosteric modulator,Agonist,,,,,pEC50,,5.4,,EC50,,4000.0,,=,Agonist potency,,,29701957, M1 receptor,13,P11229,Human,VU0486846,12305,,118124117,C1CC[C@@H]([C@H](C1)NC(=O)[C@H]1CN(c2ccccc2O1)Cc1ccc(cc1)n1cccn1)O,"InChI=1S/C25H28N4O3/c30-22-8-3-1-6-20(22)27-25(31)24-17-28(21-7-2-4-9-23(21)32-24)16-18-10-12-19(13-11-18)29-15-5-14-26-29/h2,4-5,7,9-15,20,22,24,30H,1,3,6,8,16-17H2,(H,27,31)/t20-,22-,24+/m0/s1",LZCHTDQRMCSDSE-ODGPQVTHSA-N,Allosteric modulator,Positive,,,,,pEC50,,6.51,,EC50,,310.0,,=,PAM potency,,,29701957, M1 receptor,13,P11229,Human,[3H]iperoxo,12486,,167993643,[3H][N+](C)(C)CC#CCOC1=NOCC1,"InChI=1S/C9H14N2O2/c1-11(2)6-3-4-7-12-9-5-8-13-10-9/h5-8H2,1-2H3/p+1/i/hT",CADHNBBPGYVTOA-MNYXATJNSA-O,Agonist,Agonist,,,,,pKd,,8.7,,,,,,=,,,,24863257,