target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id 15-LOX-1,1388,P16050,Human,compound 34 [PMID: 20866075],8751,,1999882,COc1ccc(cc1)C(=O)OCC#CCSc1nnc(o1)c1cccc2c1cccc2,"InChI=1S/C24H18N2O4S/c1-28-19-13-11-18(12-14-19)23(27)29-15-4-5-16-31-24-26-25-22(30-24)21-10-6-8-17-7-2-3-9-20(17)21/h2-3,6-14H,15-16H2,1H3",PYNKKMZSVFDYAC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,8.0,,Ki,,10.0,,<,,,,20866075, 15-LOX-1,1388,P16050,Human,PKUMDL_MH_1001,9141,,11841193,CN1CCN(CC1)CC(=O)N1N=C2C(C1c1ccccc1)CCC/C/2=C\c1ccccc1,"InChI=1S/C27H32N4O/c1-29-15-17-30(18-16-29)20-25(32)31-27(22-11-6-3-7-12-22)24-14-8-13-23(26(24)28-31)19-21-9-4-2-5-10-21/h2-7,9-12,19,24,27H,8,13-18,20H2,1H3/b23-19+",GEMFAWUXUVGGTE-FCDQGJHFSA-N,Allosteric modulator,Positive,,,,,pKd,,5.41,,Kd,,3900.0,,=,Determined by surface plasmon resonance (SPR),,,26290290, 15-LOX-1,1388,P16050,Human,ML351,10263,,664510,CNc1oc(nc1C#N)c1cccc2c1cccc2,"InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3",DYXYXTDIFMDJIR-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.7,,IC50,,200.0,,=,,,,24672829, 15-LOX-1,1388,P16050,Human,PD-146176,11390,,297589,c1ccc2c(c1)SCc1c2[nH]c2c1cccc2,"InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2",ZGOOPZVQMLHPFM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,6.7,,,,,,=,,,,9105693,