target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id M4 receptor,16,P08173,Human,xanomeline,57,,60809,CCCCCCOc1nsnc1C1=CCCN(C1)C,"InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3",JOLJIIDDOBNFHW-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,7.7,,7.4,,,,,=,,,,9884068|10323594|36782010|35380782, M4 receptor,16,P08173,Human,amitriptyline,200,,2160,CN(CCC=C1c2ccccc2CCc2c1cccc2)C,"InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3",KRMDCWKBEZIMAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,8.14,,Ki,,7.2,,=,,,,8100134, M4 receptor,16,P08173,Human,(+)-aceclidine,286,,6954180,CC(=O)O[C@@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m1/s1",WRJPSSPFHGNBMG-SECBINFHSA-O,Agonist,Full agonist,,,,,pEC50,,5.4,,,,,,,,,,8968358, M4 receptor,16,P08173,Human,(-)-aceclidine,288,,6979053,CC(=O)O[C@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m0/s1",WRJPSSPFHGNBMG-VIFPVBQESA-O,Agonist,Partial agonist,,,,,pEC50,,4.8,,,,,,,,,,8968358, M4 receptor,16,P08173,Human,McN-A-343,290,,5926,O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-],"InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H",CXFZFEJJLNLOTA-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,6.7,,5.6,,,,,,,,,7680092, M4 receptor,16,P08173,Human,NNC 11-1314,291,,10426487,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1,"InChI=1S/C18H19N3OS/c1-2-5-14(6-3-1)7-4-12-22-18-17(19-23-20-18)16-13-21-10-8-15(16)9-11-21/h1-3,5-6,15-16H,8-13H2",SNSMIIQEKVYNOH-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,7.3,,,,,,,,,,11504829, M4 receptor,16,P08173,Human,NNC 11-1585,292,,11757797,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1(17-37-29-27(31-39-33-29)25-19-35-13-9-23(25)10-14-35)3-21-5-7-22(8-6-21)4-2-18-38-30-28(32-40-34-30)26-20-36-15-11-24(26)12-16-36/h5-8,23-26H,9-20H2",ROEXPZFFOZZHOY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.6,,,,,,,,,,11504829, M4 receptor,16,P08173,Human,NNC 11-1607,293,,9985526,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1-4-21(6-2-16-37-29-27(31-39-33-29)25-19-35-12-8-23(25)9-13-35)18-22(5-1)7-3-17-38-30-28(32-40-34-30)26-20-36-14-10-24(26)11-15-36/h1,4-5,18,23-26H,8-17,19-20H2",TYLFZULSDOOCRC-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.1,,,,,,,,,,11504829, M4 receptor,16,P08173,Human,acetylcholine,294,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Full agonist,,yes,,,pKi,5.6,,4.5,,,,,=,,,,9224827|23798605, M4 receptor,16,P08173,Human,arecaidine propargyl ester,295,,2229,CN1CC(=CCC1)C(=O)OCC#C,"InChI=1S/C10H13NO2/c1-3-7-13-10(12)9-5-4-6-11(2)8-9/h1,5H,4,6-8H2,2H3",SPHRJZBOFYIKMC-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.9,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,arecoline,296,,2230,COC(=O)C1=CCCN(C1)C,"InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3",HJJPJSXJAXAIPN-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.5,,,,,,=,,,,7620715|9224827|32717485, M4 receptor,16,P08173,Human,bethanechol,297,,2370,CC(C[N+](C)(C)C)OC(=O)N,"InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1",NZUPCNDJBJXXRF-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,,4.0,,,,,,=,,,,7620715|9224827, M4 receptor,16,P08173,Human,carbachol,298,,2551,NC(=O)OCC[N+](C)(C)C,"InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1",VPJXQGSRWJZDOB-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,4.9,,4.3,,,,,=,,,,9224827|10323594, M4 receptor,16,P08173,Human,furtrethonium,299,,10938,C[N+](Cc1ccco1)(C)C,"InChI=1S/C8H14NO/c1-9(2,3)7-8-5-4-6-10-8/h4-6H,7H2,1-3H3/q+1",HEDXEAAVEOJUCR-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,4.3,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,methylfurmethide,300,,4141,Cc1ccc(o1)C[N+](C)(C)C,"InChI=1S/C9H16NO/c1-8-5-6-9(11-8)7-10(2,3)4/h5-6H,7H2,1-4H3/q+1",KOWVJDFMEZKDDT-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,4.7,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,milameline,301,,9571002,CO/N=C/C1=CCCN(C1)C,"InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+",YMMXHEYLRHNXAB-RMKNXTFCSA-N,Agonist,Partial agonist,,,,,pKi,,5.5,,,,,,,,,,10323594, M4 receptor,16,P08173,Human,oxotremorine,302,,4630,O=C1CCCN1CC#CCN1CCCC1,"InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2",RSDOPYMFZBJHRL-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.2,,,,,,=,,,,7620715|9224827, M4 receptor,16,P08173,Human,oxotremorine-M,303,,4629,O=C1CCCN1CC#CC[N+](C)(C)C,"InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1",CANZROMYQDHYHR-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.2,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,pentylthio-TZTP,304,,10062394,CCCCCSc1nsnc1C1=CCCN(C1)C,"InChI=1S/C13H21N3S2/c1-3-4-5-9-17-13-12(14-18-15-13)11-7-6-8-16(2)10-11/h7H,3-6,8-10H2,1-2H3",LRTWCQHCJKYNPS-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.7,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,pilocarpine,305,,5910,CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C,"InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1",QCHFTSOMWOSFHM-WPRPVWTQSA-N,Agonist,Partial agonist,,,,,pKi,,5.2,,,,,,=,,,,7620715|9224827, M4 receptor,16,P08173,Human,sabcomeline,306,,9577995,CO/N=C(/[C@H]1CN2CCC1CC2)\C#N,"InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+/t9-/m0/s1",IQWCBYSUUOFOMF-QTLFRQQHSA-N,Agonist,Partial agonist,,,,,pKi,,7.2,,,,,,,,,,10323594, M4 receptor,16,P08173,Human,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.9,,,,,,=,,,,1994002, M4 receptor,16,P08485,Rat,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.1,,,,,,,,,,1325587, M4 receptor,16,P08173,Human,p-F-HHSiD,308,,3603,Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O,"InChI=1S/C20H32FNOSi/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22/h10-13,19,23H,1-9,14-17H2",ZNSZQJHTFRQUPD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.5,,7.1,,,,,,,,,12049493|8759038, M4 receptor,16,P08173,Human,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,7.0,,,,,,=,,,,8759038, M4 receptor,16,P08485,Rat,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.5,,,,,,,,,,1325587, M4 receptor,16,P08173,Human,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.7,,6.5,,,,,,,,,8759038|2704370, M4 receptor,16,P08485,Rat,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,,,,,1325587, M4 receptor,16,P08173,Human,muscarinic toxin 1,311,,,,,,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,12512959, M4 receptor,16,P08173,Human,muscarinic toxin 2,312,,,,,,Antagonist,Antagonist,,,,,pKi,,5.9,,,,,,,,,,12512959, M4 receptor,16,P08173,Human,muscarinic toxin 3,313,,,,,,Allosteric modulator,Negative,,,,,pKi,,8.7,,,,,,=,,,,7925952|9862767, M4 receptor,16,P08173,Human,muscarinic toxin 3,313,,,,,,Antagonist,Antagonist,,,,,pKi,,8.52,,Ki,,3.0,,=,,,,29860464, M4 receptor,16,P08173,Human,muscarinic toxin 7,314,,,,,,Antagonist,Antagonist,,,,,pKi,,5.0,,,,,,>,,,,10799315, M4 receptor,16,P08173,Human,[3H]N-methyl scopolamine,317,,71183,OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12?,13-,14-,15+,16-,17+/m1/s1",LZCOQTDXKCNBEE-XJMZPCNVSA-N,Antagonist,Antagonist,,,,,pKd,10.22,,9.85,Kd,0.14,,0.06,=,,,,7687290|7651370|9224827|16369696|9846649|7562472, M4 receptor,16,P08173,Human,[3H]QNB,318,,23056,O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2,"InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2",HGMITUYOCPPQLE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,10.5,,9.7,Kd,0.2,,0.0316,=,,,,2841607|7562472, M4 receptor,16,P08173,Human,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,yes,,pKi,9.5,,8.7,,,,,=,,,,3443095|12049493|11303071|27085897, M4 receptor,16,P08485,Rat,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,,,pKi,,9.7,,,,,,=,,,,1325587, M4 receptor,16,P08173,Human,darifenacin,321,,444031,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2,"InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1",HXGBXQDTNZMWGS-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pKi,8.1,,7.3,,,,,=,,,,11303071|20590605|9671109, M4 receptor,16,P08173,Human,hexahydrodifenidol,322,,124226,OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C21H33NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1,4-5,11-12,20,23H,2-3,6-10,13-18H2",ILHSFCNKNNNPRN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,2704370, M4 receptor,16,P08173,Human,hexocyclium,323,,24199,C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O,"InChI=1S/C20H33N2O/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3/q+1",ZRYHPQCHHOKSMD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.3,,,,,,,,,,2704370, M4 receptor,16,P08173,Human,himbacine,324,,6436265,C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2,"InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1",FMPNFDSPHNUFOS-LPJDIUFZSA-N,Antagonist,Antagonist,,,,,pKi,,8.4,,Ki,,4.0,,=,,,,29860464, M4 receptor,16,P08173,Human,himbacine,324,,6436265,C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2,"InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1",FMPNFDSPHNUFOS-LPJDIUFZSA-N,Antagonist,Antagonist,,,,,pKi,8.2,,7.9,Ki,,,,=,,,,7925952|1331410|1994002, M4 receptor,16,P08173,Human,ipratropium,325,,3746,OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C,"InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1",OEXHQOGQTVQTAT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.2,,,,,,=,,,,11303071, M4 receptor,16,P08173,Human,lithocholylcholine,326,,22991950,OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C,"InChI=1S/C29H54NO2/c1-20(8-7-9-23(32)19-30(4,5)6)25-12-13-26-24-11-10-21-18-22(31)14-16-28(21,2)27(24)15-17-29(25,26)3/h20-27,31-32H,7-19H2,1-6H3/q+1",KWEWGNPMETZMTR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.3,,,,,,,,,,12235229, M4 receptor,16,P08173,Human,methoctramine,327,,4108,COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC,"InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3",RPMBYDYUVKEZJA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.5,,6.6,,,,,=,,,,8759038|2704370|1994002|9113359, M4 receptor,16,P08173,Human,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.1,,Ki,,8.0,,=,,,,29860464, M4 receptor,16,P08173,Human,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.6,,7.0,,,,,=,,,,12049493|7925952|1994002|9113359|2043926, M4 receptor,16,P08485,Rat,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,1325587, M4 receptor,16,P08173,Human,propantheline,329,,4934,O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C,"InChI=1S/C23H30NO3/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22/h6-13,16-17,22H,14-15H2,1-5H3/q+1",VVWYOYDLCMFIEM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,10.2,,,,,,=,,,,12049493, M4 receptor,16,P08173,Human,scopolamine,330,,3000322,OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C,"InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1",STECJAGHUSJQJN-FWXGHANASA-N,Antagonist,Antagonist,,,,,pKi,9.5,,9.1,,,,,=,,,,12049493|1346637, M4 receptor,16,P08173,Human,silahexocyclium,331,,130169,C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O,"InChI=1S/C19H33N2OSi/c1-21(2)15-13-20(14-16-21)17-23(22,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,22H,4,7-8,11-17H2,1-2H3/q+1",GBISIIAKUATURW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.5,,,,,,,,,,2704370, M4 receptor,16,P08173,Human,N-benzyl brucine,332,,44358893,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1,"InChI=1S/C30H33N2O4/c1-34-23-13-21-22(14-24(23)35-2)31-27(33)15-25-28-20-12-26-30(21,29(28)31)9-10-32(26,17-19(20)8-11-36-25)16-18-6-4-3-5-7-18/h3-8,13-14,20,25-26,28-29H,9-12,15-17H2,1-2H3/q+1/t20-,25-,26-,28-,29-,30+,32?/m0/s1",XFMQETLKDRNYRE-QIBSSCBHSA-N,Allosteric modulator,Negative,,,,,pKd,,4.5,,,,,,,,,,9495826, M4 receptor,16,P08173,Human,N-benzyl brucine,332,,44358893,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1,"InChI=1S/C30H33N2O4/c1-34-23-13-21-22(14-24(23)35-2)31-27(33)15-25-28-20-12-26-30(21,29(28)31)9-10-32(26,17-19(20)8-11-36-25)16-18-6-4-3-5-7-18/h3-8,13-14,20,25-26,28-29H,9-12,15-17H2,1-2H3/q+1/t20-,25-,26-,28-,29-,30+,32?/m0/s1",XFMQETLKDRNYRE-QIBSSCBHSA-N,Allosteric modulator,Neutral,,,,,pKd,,4.5,,,,,,,,,,9495826, M4 receptor,16,P08173,Human,Gö 7874,335,,3500,COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1,"InChI=1S/C27H26N4O4/c1-29(2)12-14(32)13-31-19-10-9-15(35-4)11-17(19)21-23-22(26(33)28-27(23)34)20-16-7-5-6-8-18(16)30(3)24(20)25(21)31/h5-11,14,32H,12-13H2,1-4H3,(H,28,33,34)",NYBAPNLYWRMTJL-UHFFFAOYSA-N,Allosteric modulator,Neutral,,,,,pKd,,5.7,,,,,,,,,,10860942, M4 receptor,16,P08173,Human,KT 5720,337,,16219545,CCCCCCOC(=O)[C@@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1",ZHEHVZXPFVXKEY-IKZDWWSZSA-N,Allosteric modulator,Neutral,,,,,pKd,,6.4,,,,,,,,,,10860942, M4 receptor,16,P08173,Human,"WIN 51,708",339,,9803245,C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1,"InChI=1S/C29H33N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,17,19-22,33H,9-16H2,2-3H3/t19-,20+,21-,22-,27-,28-,29-/m0/s1",AIIXYCDTEGICEE-HZVAOYAWSA-N,Allosteric modulator,Negative,,,,,pKd,,6.2,,,,,,,,,,12435818, M4 receptor,16,P08173,Human,"WIN 62,577",340,,15118529,C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2,"InChI=1S/C29H31N3O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24/h1,5-8,15,17,20-22,33H,9-14,16H2,2-3H3/t20-,21+,22+,27+,28+,29+/m1/s1",YBCYJDNOPAFFOW-XOAARHKISA-N,Allosteric modulator,Negative,,,,,pKd,,5.9,,,,,,,,,,12435818, M4 receptor,16,P08173,Human,alcuronium,341,,5311001,C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C,"InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13?,30-14?,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47?,48?/m0/s1",MUQUYTSLDVKIOF-NCQXAQDZSA-N,Allosteric modulator,Negative,,,,,pKd,,5.6,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,brucine,342,,442021,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2,"InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1",RRKTZKIUPZVBMF-IBTVXLQLSA-N,Allosteric modulator,Negative,,,,,pKd,6.0,,4.7,,,,,,,,,9224827|9495826, M4 receptor,16,P08173,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Neutral,,,,,pKd,,3.6,,,,,,,,,,9495826, M4 receptor,16,P08173,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Positive,,,,,pKd,,3.6,,,,,,,,,,9495826, M4 receptor,16,P08173,Human,N-chloromethyl-brucine,344,,44358908,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl,"InChI=1S/C24H28ClN2O4/c1-29-17-8-15-16(9-18(17)30-2)26-21(28)10-19-22-14-7-20-24(15,23(22)26)4-5-27(20,12-25)11-13(14)3-6-31-19/h3,8-9,14,19-20,22-23H,4-7,10-12H2,1-2H3/q+1/t14-,19-,20-,22-,23-,24+,27?/m0/s1",GCEPQLWZBVGLQN-CQIPDZJVSA-N,Allosteric modulator,Neutral,,,,,pKd,,4.4,,,,,,,,,,9495826, M4 receptor,16,P08173,Human,vinburnine,345,,71203,CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1,"InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1",WYJAPUKIYAZSEM-MOPGFXCFSA-N,Allosteric modulator,Positive,,,,,pKd,,4.6,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,staurosporine,346,,44259,CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O,"InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1",HKSZLNNOFSGOKW-FYTWVXJKSA-N,Allosteric modulator,Neutral,,,,,pKd,,5.3,,,,,,,,,,10860942, M4 receptor,16,P08173,Human,strychnine,347,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Allosteric modulator,Positive,,,,,pKd,5.0,,4.8,,,,,,,,,7651370|9224827, M4 receptor,16,P08173,Human,thiochrome,348,,66706,OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C,"InChI=1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3",GTQXMAIXVFLYKF-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKd,,4.0,,,,,,=,,,,14722259, M4 receptor,16,P08173,Human,vincamine,349,,15376,COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3,"InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1",RXPRRQLKFXBCSJ-GIVPXCGWSA-N,Allosteric modulator,Positive,,,,,pKd,,4.2,,,,,,,,,,9224827, M4 receptor,16,P08173,Human,dicyclomine,355,,3042,CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC,"InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3",CURUTKGFNZGFSE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.3,,Ki,,5.0,,=,,,,29860464, M4 receptor,16,P08173,Human,oxybutynin,359,,4634,CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC,"InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3",XIQVNETUBQGFHX-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.7,,8.4,,,,,=,,,,22243489|20590605, M4 receptor,16,P08173,Human,tolterodine,360,,443879,Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O,"InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1",OOGJQPCLVADCPB-HXUWFJFHSA-N,Antagonist,Antagonist,,,,,pKi,8.4,,8.3,,,,,=,,,,20590605|9671109, M4 receptor,16,P08173,Human,tripitramine,361,,132947,CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C,"InChI=1S/C64H77N13O6/c1-72(41-20-8-5-17-35-65-44-56(78)75-53-32-14-11-26-47(53)62(81)69-50-29-23-36-66-59(50)75)39-18-6-3-4-7-19-40-73(2)42-21-9-10-22-43-74(45-57(79)76-54-33-15-12-27-48(54)63(82)70-51-30-24-37-67-60(51)76)46-58(80)77-55-34-16-13-28-49(55)64(83)71-52-31-25-38-68-61(52)77/h11-16,23-34,36-38,65H,3-10,17-22,35,39-46H2,1-2H3,(H,69,81)(H,70,82)(H,71,83)",YUJOQEAGGUIMED-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.94,,,,,,=,,,,18595721, M4 receptor,16,P08173,Human,tiotropium,367,,5487427,O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17+",LERNTVKEWCAPOY-FPISHFTHSA-N,Antagonist,Antagonist,,,,,pKi,10.6,,10.2,,,,,=,,,,22854200|21036042, M4 receptor,16,P08173,Human,[3H]AF DX-384,368,,119357,CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC,"InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)",MZDYABXXPZNUCT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,8.7,,,,,,=,,,,1941609|29515448|32079174, M4 receptor,16,P08485,Rat,VU0152099,3256,,1541501,Cc1cc(C)c2c(n1)sc(c2N)C(=O)NCc1ccc2c(c1)OCO2,"InChI=1S/C18H17N3O3S/c1-9-5-10(2)21-18-14(9)15(19)16(25-18)17(22)20-7-11-3-4-12-13(6-11)24-8-23-12/h3-6H,7-8,19H2,1-2H3,(H,20,22)",AZOGCTMOKNTHIU-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,6.39,,EC50,,403.0,,=,,,,18772318, M4 receptor,16,P08173,Human,3-quinuclidinyl-benzilate,3260,,23056,O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2,"InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2",HGMITUYOCPPQLE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,10.4,,Ki,,0.04,,=,,,,29860464, M4 receptor,16,P08173,Human,LY2033298,3262,,11536903,COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1,"InChI=1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)",CTEGQKDJTBWFHW-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKB,5.5,,4.9,,,,,=,,,,14595031|18678919, M4 receptor,16,P08485,Rat,VU0152100,3263,,864492,COc1ccc(cc1)CNC(=O)c1sc2c(c1N)c(C)cc(n2)C,"InChI=1S/C18H19N3O2S/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12/h4-8H,9,19H2,1-3H3,(H,20,22)",MDNWGCQSCGNTKH-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,6.42,,EC50,,380.0,,=,,,,18772318, M4 receptor,16,P08173,Human,AFDX384,3264,,119357,CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC,"InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)",MZDYABXXPZNUCT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.0,,7.3,,,,,=,,,,1994002|27085897, M4 receptor,16,P08173,Human,VU0255035,3274,,24768606,O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2,"InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2",WXDHQWPQLKGANZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.9,,,,,,=,,,,19407080, M4 receptor,16,P08485,Rat,guanylpirenzepine,3276,,129786,NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N7O2/c20-19(21)25-10-8-24(9-11-25)12-16(27)26-15-6-2-1-4-13(15)18(28)23-14-5-3-7-22-17(14)26/h1-7H,8-12H2,(H3,20,21)(H,23,28)",YGBQWISDDSXPRF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.2,,,,,,=,,,,8813552, M4 receptor,16,P08173,Human,iperoxo,6937,,10104167,C[N+](CC#CCOC1=NOCC1)(C)C,"InChI=1S/C10H17N2O2/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10/h6-9H2,1-3H3/q+1",WXXOCGISBCTWPW-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,24863257, M4 receptor,16,P08173,Human,LY2119620,6938,,57664406,CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1,"InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H,3-9,21H2,1-2H3,(H,22,27)",TYTGOXSAAQWLPJ-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKd,,5.5,,,,,,=,,,,24807965, M4 receptor,16,P08173,Human,biperiden,7128,,2381,OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1,"InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2",YSXKPIUOCJLQIE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,8.62,,Kd,,2.4,,=,,,,1346637, M4 receptor,16,P08173,Human,oxyphenonium,7257,,5749,CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C,"InChI=1S/C21H34NO3/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3/q+1",GFRUPHOKLBPHTQ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.84,,Ki,,0.145,,=,,,,29860464, M4 receptor,16,P08173,Human,tropicamide,7319,,5593,CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1,"InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3",BGDKAVGWHJFAGW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.9,,,,,,=,,,,29860464, M4 receptor,16,P08173,Human,umeclidinium,7354,,11519070,OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1,"InChI=1S/C29H34NO2/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25/h1-15,31H,16-24H2/q+1",FVTWTVQXNAJTQP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,10.3,,,,,,=,,,,23435542, M4 receptor,16,P08485,Rat,methacholine,7438,,1993,CC(C[N+](C)(C)C)OC(=O)C,"InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1",NZWOPGCLSHLLPA-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.8,,Ki,,1600.0,,=,,,,7620715|9622546, M4 receptor,16,P08173,Human,aclidinium,7449,,11434515,O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2,"InChI=1S/C26H30NO4S2/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1",ASMXXROZKSBQIH-VITNCHFBSA-N,Antagonist,Antagonist,,,,,pKi,,10.0,,,,,,=,,,,21036042, M4 receptor,16,P08173,Human,glycopyrrolate,7459,,3494,O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C,"InChI=1S/C19H28NO3/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3/q+1",ANGKOCUUWGHLCE-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,10.0,,9.1,,,,,=,,,,21036043|22854200, M4 receptor,16,P08173,Human,solifenacin,7483,,154059,O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2,"InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1",FBOUYBDGKBSUES-VXKWHMMOSA-N,Antagonist,Antagonist,,,,,pKi,,6.8,,,,,,=,,,,20590605, M4 receptor,16,P08173,Human,dosulepin,7549,,5282426,CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C,"InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11-",PHTUQLWOUWZIMZ-BOPFTXTBSA-N,Antagonist,Antagonist,,,,,pKi,,7.21,,Ki,,61.0,,=,,,,8100134, M4 receptor,16,P08173,Human,VU0010010,7633,,154733029,O=C(C1Sc2c(C1N)c(C)cc(n2)C)NCc1ccc(cc1)Cl,"InChI=1S/C17H18ClN3OS/c1-9-7-10(2)21-17-13(9)14(19)15(23-17)16(22)20-8-11-3-5-12(18)6-4-11/h3-7,14-15H,8,19H2,1-2H3,(H,20,22)",IKKFWVKRPITRNW-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,19201489, M4 receptor,16,P08173,Human,UH-AH 37,8583,,129140,CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2,"InChI=1S/C21H22ClN3O2/c1-24-11-9-14(10-12-24)13-19(26)25-18-8-3-2-5-15(18)21(27)23-17-7-4-6-16(22)20(17)25/h2-8,14H,9-13H2,1H3,(H,23,27)",UFJWXHOFKIGIAF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.4,,8.3,,,,,=,,,,2043926|9671109, M4 receptor,16,P08173,Human,AQ-RA 741,8584,,129989,CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)",BCUGCHZRMKTPMU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.2,,7.8,,,,,=,,,,1994002|9671109, M4 receptor,16,P08173,Human,AE9C90CB,8586,,9862598,CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2,"InChI=1S/C21H24N2O2/c1-23(14-19-17-12-22-13-18(17)19)20(24)21(25,15-8-4-2-5-9-15)16-10-6-3-7-11-16/h2-11,17-19,22,25H,12-14H2,1H3/t17-,18+,19-",AARSINSGAQDAKQ-REPLKXPHSA-N,Antagonist,Antagonist,,,,,pKi,,9.5,,,,,,=,,,,20590605, M4 receptor,16,P08173,Human,ML381,8591,,42519285,CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C,"InChI=1S/C21H21N3O4/c1-14(19-9-4-5-10-22-19)24(3)21(26)20-12-18(28-23-20)13-27-17-8-6-7-16(11-17)15(2)25/h4-12,14H,13H2,1-3H3/t14-/m0/s1",JMYDHMCYZKRDPD-AWEZNQCLSA-N,Antagonist,Antagonist,,,,,pKi,,4.52,,Ki,,30000.0,,<,,,,24692176, M4 receptor,16,P08173,Human,[3H]acetylcholine,8593,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKd,,8.2,,Kd,,6.3,,=,,,,14722259, M4 receptor,16,P08173,Human,cevimeline,9658,,2684,CC1SCC2(O1)CN1CCC2CC1,"InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3",WUTYZMFRCNBCHQ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.99,,Ki,,1012.0,,=,Displacement of [3H]QNB from cloned receptor.,,,9399977, M4 receptor,16,P08173,Human,(S)-dimetindene,10104,,6604866,CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C,"InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m1/s1",MVMQESMQSYOVGV-OAHLLOKOSA-N,Antagonist,Antagonist,,,,,pKi,,6.53,,Ki,,295.1,,=,Binding to hM4 receptors expressed in CHO cells.,,,12593665, M4 receptor,16,P08173,Human,revefenacin,10129,,11753673,O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C,"InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41)23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)",FYDWDCIFZSGNBU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.26,,Ki,,0.55,,=,"Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM4 receptor, and displacement of [3H]NMS tracer.",,,29736245, M4 receptor,16,P08173,Human,mepenzolic acid,10470,,4057,O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C,"InChI=1S/C21H26NO3/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,9,14-16H2,1-2H3/q+1",GKNPSSNBBWDAGH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.44,,Ki,,0.36,,=,,,,29860464, M4 receptor,16,P08173,Human,PD 102807,11498,,4995951,CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC,"InChI=1S/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3",VDDUJINYXKGZLV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.6,,7.4,,,,,=,,,,27085897|10576595, M4 receptor,16,P08173,Human,PCS1055,11499,,10894911,c1ccc(cc1)CN1CCC(CC1)CCNc1nnc2c(c1)CCCc1c2cccc1,"InChI=1S/C27H32N4/c1-2-7-22(8-3-1)20-31-17-14-21(15-18-31)13-16-28-26-19-24-11-6-10-23-9-4-5-12-25(23)27(24)30-29-26/h1-5,7-9,12,19,21H,6,10-11,13-18,20H2,(H,28,29)",ATHZIFFSGSWIAU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.2,,,,,,=,,,,27085897, M4 receptor,16,P08173,Human,VU0467154,12301,,73774630,Cc1c(nnc2c1c(c(s2)C(=O)NCc1ccc(cc1)S(=O)(=O)C(F)(F)F)N)C,"InChI=1S/C17H15F3N4O3S2/c1-8-9(2)23-24-16-12(8)13(21)14(28-16)15(25)22-7-10-3-5-11(6-4-10)29(26,27)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25)",UDSFKIFLJPECRN-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,6.2,,EC50,,631.0,,=,Potentiation of ACh response at human receptor,,,25137629, M4 receptor,16,P08485,Rat,VU0467154,12301,,73774630,Cc1c(nnc2c1c(c(s2)C(=O)NCc1ccc(cc1)S(=O)(=O)C(F)(F)F)N)C,"InChI=1S/C17H15F3N4O3S2/c1-8-9(2)23-24-16-12(8)13(21)14(28-16)15(25)22-7-10-3-5-11(6-4-10)29(26,27)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25)",UDSFKIFLJPECRN-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,7.75,,EC50,,17.8,,=,,,,25137629, M4 receptor,16,,Monkey,VU0467154,12301,,73774630,Cc1c(nnc2c1c(c(s2)C(=O)NCc1ccc(cc1)S(=O)(=O)C(F)(F)F)N)C,"InChI=1S/C17H15F3N4O3S2/c1-8-9(2)23-24-16-12(8)13(21)14(28-16)15(25)22-7-10-3-5-11(6-4-10)29(26,27)17(18,19)20/h3-6H,7,21H2,1-2H3,(H,22,25)",UDSFKIFLJPECRN-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,6.0,,EC50,,1000.0,,=,,,,25137629, M4 receptor,16,P08173,Human,[3H]iperoxo,12486,,167993643,[3H][N+](C)(C)CC#CCOC1=NOCC1,"InChI=1S/C9H14N2O2/c1-11(2)6-3-4-7-12-9-5-8-13-10-9/h5-8H2,1-2H3/p+1/i/hT",CADHNBBPGYVTOA-MNYXATJNSA-O,Agonist,Agonist,,,,,pKd,,10.1,,Kd,,0.08,,=,,,,24863257,