target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id A1 receptor,18,P30542,Human,"(R,S)-PHPNECA",369,,91827339,CCNC(=O)[C@H]1O[C@H]([C@H]([C@H]1O)O)n1cnc2c1nc(C#CC(c1ccccc1)O)nc2N,"InChI=1S/C21H22N6O5/c1-2-23-20(31)17-15(29)16(30)21(32-17)27-10-24-14-18(22)25-13(26-19(14)27)9-8-12(28)11-6-4-3-5-7-11/h3-7,10,12,15-17,21,28-30H,2H2,1H3,(H,23,31)(H2,22,25,26)/t12?,15-,16+,17+,21-/m1/s1",WOAZCBPWCCREDO-CERUIEQFSA-N,Agonist,Full agonist,,,,,pKi,,8.6,,,,,,,,,,12109910, A1 receptor,18,P25099,Rat,2-chloroadenosine,372,,8974,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N,"InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1",BIXYYZIIJIXVFW-UUOKFMHZSA-N,Agonist,Agonist,,,,,pKi,,8.17,,Ki,,6.7,,=,,,,8441759, A1 receptor,18,P30542,Human,2-chloroadenosine,372,,8974,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N,"InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1",BIXYYZIIJIXVFW-UUOKFMHZSA-N,Agonist,Full agonist,,,,,pKi,5.6,,5.2,,,,,=,,,,7798201|9920910, A1 receptor,18,P30542,Human,2-hexynyl-NECA,373,,164437,CCCCC#Cc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC,"InChI=1S/C18H24N6O4/c1-3-5-6-7-8-10-22-15(19)11-16(23-10)24(9-21-11)18-13(26)12(25)14(28-18)17(27)20-4-2/h9,12-14,18,25-26H,3-6H2,1-2H3,(H,20,27)(H2,19,22,23)/t12-,13+,14-,18+/m0/s1",FDEACFAXFCKCHZ-MOROJQBDSA-N,Agonist,Full agonist,,,,,pKi,,7.2,,,,,,=,,,,12109910, A1 receptor,18,P25099,Rat,CCPA,374,,123807,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1",XSMYYYQVWPZWIZ-IDTAVKCVSA-N,Agonist,Agonist,,,,,pKi,,8.89,,Ki,,1.3,,=,,,,, A1 receptor,18,P30542,Human,CCPA,374,,123807,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1",XSMYYYQVWPZWIZ-IDTAVKCVSA-N,Agonist,Full agonist,,,,,pKi,8.1,,7.7,,,,,=,,,,16020631|16518376, A1 receptor,18,P25099,Rat,CGS 21680,375,,3086599,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N,"InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1",PAOANWZGLPPROA-RQXXJAGISA-N,Agonist,Agonist,,,,,pKi,,5.74,,Ki,,1800.0,,=,,,,, A1 receptor,18,P30542,Human,CGS 21680,375,,3086599,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N,"InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1",PAOANWZGLPPROA-RQXXJAGISA-N,Agonist,Full agonist,,,,,pKi,6.4,,5.8,,,,,=,,,,15476669|16518376, A1 receptor,18,P30542,Human,LUF5831,376,,135494270,OCCSc1nc(N)c(c(c1C#N)c1ccc(cc1)O)C#N,"InChI=1S/C15H12N4O2S/c16-7-11-13(9-1-3-10(21)4-2-9)12(8-17)15(19-14(11)18)22-6-5-20/h1-4,20-21H,5-6H2,(H2,18,19)",GYIHPWFWFRELQC-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,7.7,,,,,,,,,,16444290, A1 receptor,18,P25099,Rat,NECA,377,,448222,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1",JADDQZYHOWSFJD-FLNNQWSLSA-N,Agonist,Agonist,,,,,pKi,,8.29,,Ki,,5.1,,=,,,,, A1 receptor,18,P30542,Human,NECA,377,,448222,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1",JADDQZYHOWSFJD-FLNNQWSLSA-N,Agonist,Full agonist,,,,,pKi,8.2,,5.3,,,,,=,,,,7798201|9920910|8300561|15476669|14662005, A1 receptor,18,P30542,Human,PENECA,378,,9953255,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(C#Cc1ccccc1)nc2N,"InChI=1S/C20H20N6O4/c1-2-22-19(29)16-14(27)15(28)20(30-16)26-10-23-13-17(21)24-12(25-18(13)26)9-8-11-6-4-3-5-7-11/h3-7,10,14-16,20,27-28H,2H2,1H3,(H,22,29)(H2,21,24,25)/t14-,15+,16-,20+/m0/s1",SWXXHYTUMIMRFO-KSVNGYGVSA-N,Agonist,Full agonist,,,,,pKi,,6.2,,,,,,,,,,12109910, A1 receptor,18,P30542,Human,[3H]CCPA,379,,123807,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1",XSMYYYQVWPZWIZ-IDTAVKCVSA-N,Agonist,Full agonist,,,,,pKd,,9.2,,Kd,,0.631,,=,,,,9920910|9459566, A1 receptor,18,P30542,Human,cyclopentyladenosine,380,,657378,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1,"InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1",SQMWSBKSHWARHU-SDBHATRESA-N,Agonist,Full agonist,,,,,pKi,9.4,,6.5,,,,,=,,,,9827575|15740718|15476669|16444290|16518376|7798201|9920910, A1 receptor,18,P30542,Human,AS100,381,,135489238,CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl,"InChI=1S/C23H25Cl2N7O4/c1-4-8-31-21-19(22(34)32(9-5-2)23(31)35)27-20(28-21)16-11-18(29-30(16)3)36-12-17(33)26-13-6-7-14(24)15(25)10-13/h6-7,10-11H,4-5,8-9,12H2,1-3H3,(H,26,33)(H,27,28)",OESRCCUPNGDTIR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.5,,,,,,,,,,16219300, A1 receptor,18,P30542,Human,AS70,382,,135443367,CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1,"InChI=1S/C27H34N8O4/c1-4-11-34-25-23(26(37)35(12-5-2)27(34)38)28-24(29-25)20-17-21(30-31(20)3)39-18-22(36)33-15-13-32(14-16-33)19-9-7-6-8-10-19/h6-10,17H,4-5,11-16,18H2,1-3H3,(H,28,29)",BVHLYIIHYJFKSI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.6,,,,,,,,,,16219300, A1 receptor,18,P30542,Human,AS99,383,,135522368,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C,"InChI=1S/C25H31N7O4/c1-6-10-31-23-21(24(34)32(11-7-2)25(31)35)27-22(28-23)18-13-20(29-30(18)5)36-14-19(33)26-17-9-8-15(3)16(4)12-17/h8-9,12-13H,6-7,10-11,14H2,1-5H3,(H,26,33)(H,27,28)",FCMUQGWJTIVYIU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.1,,,,,,,,,,16219300, A1 receptor,18,P30542,Human,CGS 15943,384,,2690,Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1,"InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)",MSJODEOZODDVGW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.46,,Ki,,3.5,,=,,,,9933143, A1 receptor,18,P25099,Rat,CGS 15943,384,,2690,Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1,"InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)",MSJODEOZODDVGW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.19,,Ki,,6.4,,=,,,,, A1 receptor,18,P30542,Human,8-cyclopentyltheophylline,385,,1917,Cn1c2nc([nH]c2c(=O)n(c1=O)C)C1CCCC1,"InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)",SCVHFRLUNIOSGI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.0,,7.5,,,,,,,,,9827575, A1 receptor,18,P30542,Human,DPCPX,386,,1329,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)",FFBDFADSZUINTG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.2,,7.4,Ki,39.8,,0.63,=,,,,9920910|16020631|15740718|16902942|8032613, A1 receptor,18,P25099,Rat,DPCPX,386,,1329,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)",FFBDFADSZUINTG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.74,,9.0,Ki,1.0,,0.18,=,,,,16902942|12014951|2067592, A1 receptor,18,P30542,Human,FR194921,387,,9821511,CN1CCC(CC1)n1nc(ccc1=O)c1c(nn2c1cccc2)c1ccccc1,"InChI=1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3",YHDRUTMZCJZJAL-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.9,,,,,,,,,,15351792, A1 receptor,18,P30542,Human,isobutylmethylxanthine,388,,3758,CC(Cn1c(=O)n(C)c(=O)c2c1nc[nH]2)C,"InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)",APIXJSLKIYYUKG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.1,,,,,,,,,,7798201, A1 receptor,18,P30542,Human,L-97-1,389,,11627742,OCCN(CCn1c(Cc2ccccc2)nc2c1c(=O)n(CCC)c(=O)n2CCc1ccc(cc1)N)CC,"InChI=1S/C29H38N6O3/c1-3-15-35-28(37)26-27(34(29(35)38)16-14-22-10-12-24(30)13-11-22)31-25(21-23-8-6-5-7-9-23)33(26)18-17-32(4-2)19-20-36/h5-13,36H,3-4,14-21,30H2,1-2H3",QVEHDKFBFDUCEZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.2,,,,,,,,,,16020631, A1 receptor,18,P30542,Human,MRE 2029F20,390,,135484064,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2,"InChI=1S/C24H27N7O6/c1-4-8-30-22-20(23(33)31(9-5-2)24(30)34)26-21(27-22)15-11-19(28-29(15)3)35-12-18(32)25-14-6-7-16-17(10-14)37-13-36-16/h6-7,10-11H,4-5,8-9,12-13H2,1-3H3,(H,25,32)(H,26,27)",DBWQRFKXNBVPGA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.7,,,,,,=,,,,16219300|14998332, A1 receptor,18,P25099,Rat,MRS1041,392,,10247549,CCOc1cc(OCC)c2c(c1)oc(c(c2=O)OCC)c1ccccc1,"InChI=1S/C21H22O5/c1-4-23-15-12-16(24-5-2)18-17(13-15)26-20(14-10-8-7-9-11-14)21(19(18)22)25-6-3/h7-13H,4-6H2,1-3H3",YMQQPRDUZIXHBJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.2,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1042,393,,10500941,CCCOc1cc(OCCC)c2c(c1)oc(c(c2=O)OCCC)c1ccccc1,"InChI=1S/C24H28O5/c1-4-12-26-18-15-19(27-13-5-2)21-20(16-18)29-23(17-10-8-7-9-11-17)24(22(21)25)28-14-6-3/h7-11,15-16H,4-6,12-14H2,1-3H3",ABZJCSJCNNCZRY-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1062,394,,18784677,COc1ccc2c(c1)C(=O)C(C(O2)(C#Cc1ccccc1)c1ccccc1)O,"InChI=1S/C24H18O4/c1-27-19-12-13-21-20(16-19)22(25)23(26)24(28-21,18-10-6-3-7-11-18)15-14-17-8-4-2-5-9-17/h2-13,16,23,26H,1H3",ITOHYACNWAMSCT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.3,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1065,395,,10710647,COc1c2c(=O)cc(oc2cc2c1cco2)/C=C/c1ccccc1,"InChI=1S/C20H14O4/c1-22-20-15-9-10-23-17(15)12-18-19(20)16(21)11-14(24-18)8-7-13-5-3-2-4-6-13/h2-12H,1H3/b8-7+",HTBFQFPYNPJVLO-BQYQJAHWSA-N,Antagonist,Antagonist,,,,,pKi,,4.5,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1066,396,,10806465,CCOc1c2c(=O)cc(oc2cc2c1cco2)/C=C/c1ccccc1,"InChI=1S/C21H16O4/c1-2-23-21-16-10-11-24-18(16)13-19-20(21)17(22)12-15(25-19)9-8-14-6-4-3-5-7-14/h3-13H,2H2,1H3/b9-8+",TZRUAYHMQMKKLT-CMDGGOBGSA-N,Antagonist,Antagonist,,,,,pKi,,4.4,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1084,397,,10593671,CCCOc1c2c(=O)cc(oc2cc2c1cco2)/C=C/c1ccccc1,"InChI=1S/C22H18O4/c1-2-11-25-22-17-10-12-24-19(17)14-20-21(22)18(23)13-16(26-20)9-8-15-6-4-3-5-7-15/h3-10,12-14H,2,11H2,1H3/b9-8+",RCPBGBWHKGZPFO-CMDGGOBGSA-N,Antagonist,Antagonist,,,,,pKi,,4.4,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1086,398,,10813088,CCOc1ccc(c(c1)OCC)c1oc2cc(OCC)cc(c2c(=O)c1OCC)OCC,"InChI=1S/C25H30O7/c1-6-27-16-11-12-18(19(13-16)29-8-3)24-25(31-10-5)23(26)22-20(30-9-4)14-17(28-7-2)15-21(22)32-24/h11-15H,6-10H2,1-5H3",JVGSHXMDRPGOQM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.5,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1093,399,,10568125,CCOc1cc(O)c2c(c1)oc(c(c2=O)OCC)c1ccccc1,"InChI=1S/C19H18O5/c1-3-22-13-10-14(20)16-15(11-13)24-18(12-8-6-5-7-9-12)19(17(16)21)23-4-2/h5-11,20H,3-4H2,1-2H3",ZPEWNDIPSPULBP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.7,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS1132,400,,736736,O=c1c(Cl)c(oc2c1cccc2)c1ccccc1,InChI=1S/C15H9ClO2/c16-13-14(17)11-8-4-5-9-12(11)18-15(13)10-6-2-1-3-7-10/h1-9H,FHXDSQYFCFWKAW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.6,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS923,401,,631105,COc1ccc(c(c1)OC)c1oc2cc(OC)cc(c2c(=O)c1OC)OC,"InChI=1S/C20H20O7/c1-22-11-6-7-13(14(8-11)24-3)19-20(26-5)18(21)17-15(25-4)9-12(23-2)10-16(17)27-19/h6-10H,1-5H3",KPJGABLCRGWDRB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.6,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,MRS928,402,,117900,COc1cc(OC)c2c(c1)oc(c(c2=O)OC)c1ccccc1,"InChI=1S/C18H16O5/c1-20-12-9-13(21-2)15-14(10-12)23-17(18(22-3)16(15)19)11-7-5-4-6-8-11/h4-10H,1-3H3",CBTHKWVPSIGKMI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,,,,,8691424, A1 receptor,18,P30542,Human,SCH 58261,403,,176408,Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1,"InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)",UTLPKQYUXOEJIL-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.3,,6.1,,,,,=,,,,8300561|9933143|16518376, A1 receptor,18,P30542,Human,xanthine amine congener,404,,5697,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN,"InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)",FIQGIOAELHTLHM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,7.5,,,,,,=,,,,19317449, A1 receptor,18,P30542,Human,xanthine amine congener,404,,5697,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN,"InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)",FIQGIOAELHTLHM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.6,,,,,,,,,,7798201, A1 receptor,18,P30542,Human,ZM-241385,405,,176407,Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1,"InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)",PWTBZOIUWZOPFT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.6,,6.1,,,,,=,,,,9933143|16518376, A1 receptor,18,P30542,Human,[3H]DPCPX,406,,53319341,C([3H])CC(n1c2nc([nH]c2c(=O)n(c1=O)C(CC[3H])[3H])C1CCCC1)[3H],"InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)/i1T,2T,9T,10T",FFBDFADSZUINTG-LEZITTIZSA-N,Antagonist,Antagonist,,,,,pKd,9.2,,8.4,Kd,1.2,,0.6,,,,,9920910|8300561|9459566|9827575|9933143|11705449, A1 receptor,18,P30542,Human,caffeine,407,,2519,Cn1cnc2c1c(=O)n(C)c(=O)n2C,"InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3",RYYVLZVUVIJVGH-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,4.97,,4.35,Ki,44900.0,,10700.0,=,,,,8469419|14563788, A1 receptor,18,P25099,Rat,caffeine,407,,2519,Cn1cnc2c1c(=O)n(C)c(=O)n2C,"InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3",RYYVLZVUVIJVGH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,4.39,,4.36,Ki,44000.0,,41000.0,=,,,,8182711|1658821, A1 receptor,18,P25099,Rat,flavanone,408,,10251,O=C1CC(Oc2c1cccc2)c1ccccc1,"InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2",ZONYXWQDUYMKFB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.5,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,flavone,409,,10680,O=c1cc(oc2c1cccc2)c1ccccc1,InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,VHBFFQKBGNRLFZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.5,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,galangin,410,,5281616,Oc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccccc1,"InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H",VCCRNZQBSJXYJD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.1,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,morin,411,,5281670,Oc1ccc(c(c1)O)c1oc2cc(O)cc(c2c(=O)c1O)O,"InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H",YXOLAZRVSSWPPT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.9,,,,,,,,,,8691424, A1 receptor,18,P25099,Rat,sakuranetin,412,,73571,COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O,"InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1",DJOJDHGQRNZXQQ-AWEZNQCLSA-N,Antagonist,Antagonist,,,,,pKi,,5.1,,,,,,,,,,8691424, A1 receptor,18,P30542,Human,theophylline,413,,2153,Cn1c(=O)n(C)c2c(c1=O)[nH]cn2,"InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)",ZFXYFBGIUFBOJW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,5.2,,4.9,,,,,=,,,,7798201|9459566|16219300|11705449, A1 receptor,18,P25099,Rat,theophylline,413,,2153,Cn1c(=O)n(C)c2c(c1=O)[nH]cn2,"InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)",ZFXYFBGIUFBOJW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,5.06,,4.85,Ki,14000.0,,8740.0,=,,,,8230124, A1 receptor,18,P25099,Rat,(R)-PIA,414,,93205,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1",RIRGCFBBHQEQQH-SSFGXONLSA-N,Agonist,Agonist,,,,,pKi,,8.92,,Ki,,1.2,,=,,,,8441759, A1 receptor,18,P30542,Human,(R)-PIA,414,,93205,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1",RIRGCFBBHQEQQH-SSFGXONLSA-N,Agonist,Full agonist,,,,,pKi,8.7,,6.4,,,,,=,,,,7798201|9920910|8300561|15476669|9459566, A1 receptor,18,P30542,Human,(S)-PIA,415,,5312112,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13+,15+,16+,19+/m0/s1",RIRGCFBBHQEQQH-KFAHYOAQSA-N,Agonist,Full agonist,,,,,pKi,6.0,,4.6,,,,,,,,,7798201|8300561, A1 receptor,18,P30542,Human,piclidenoson,422,,123683,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I,"InChI=1S/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1",HUJXGQILHAUCCV-MOROJQBDSA-N,Agonist,Agonist,,,,,pKi,,7.29,,Ki,,51.0,,=,,,,16518376, A1 receptor,18,P25099,Rat,N(6)-cyclohexyladenosine,423,,9841284,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1,"InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1",SZBULDQSDUXAPJ-XNIJJKJLSA-N,Agonist,Agonist,,,,,pKi,,9.07,,Ki,,0.85,,=,,,,8441759, A1 receptor,18,P30542,Human,MRS1754,449,,6603931,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N,"InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)",AJBBEYXFRYFVNM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.39,,Ki,,403.0,,=,,,,10737749, A1 receptor,18,P25099,Rat,MRS1754,449,,6603931,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N,"InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)",AJBBEYXFRYFVNM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.77,,Ki,,16.8,,=,,,,10737749, A1 receptor,18,P30542,Human,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Agonist,,,,,pKi,,6.66,,Ki,,220.0,,=,,,,16518376, A1 receptor,18,Q60612,Mouse,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Agonist,,,,,pKi,,7.46,,Ki,,35.0,,=,,,,, A1 receptor,18,P25099,Rat,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Agonist,,,,,pKi,,6.55,,Ki,,280.0,,=,,,,, A1 receptor,18,P30542,Human,MRE 3008F20,459,,5310960,CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC,"InChI=1S/C21H20N8O3/c1-3-10-28-12-15-17(26-28)24-20(25-21(30)22-13-6-8-14(31-2)9-7-13)29-19(15)23-18(27-29)16-5-4-11-32-16/h4-9,11-12H,3,10H2,1-2H3,(H2,22,24,25,26,30)",CJRNHKSLHHWUAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.0,,5.9,,,,,=,,,,16219300|10779381|16518376, A1 receptor,18,P30542,Human,MRS1191,470,,393594,CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1,"InChI=1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3",SNVFDPHQAOXWJZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,, A1 receptor,18,P25099,Rat,MRS1191,470,,393594,CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1,"InChI=1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3",SNVFDPHQAOXWJZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.4,,Ki,,40100.0,,=,,,,, A1 receptor,18,P30542,Human,MRS1523,474,,3661570,CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC,"InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3",UUSHFEVEROROSP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,, A1 receptor,18,P25099,Rat,MRS1523,474,,3661570,CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC,"InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3",UUSHFEVEROROSP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.81,,Ki,,15600.0,,=,,,,, A1 receptor,18,P30542,Human,adenosine,2844,,60961,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1",OIRDTQYFTABQOQ-KQYNXXCUSA-N,Agonist,Agonist,,yes,yes,,pKi,,7.0,,Ki,,100.0,,~,,,,14662005, A1 receptor,18,P25099,Rat,adenosine,2844,,60961,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1",OIRDTQYFTABQOQ-KQYNXXCUSA-N,Agonist,Agonist,,yes,,,pKi,,7.14,,Ki,,73.0,,=,,,,14662005, A1 receptor,18,P25099,Rat,VUF5574,3280,,4046493,COc1ccccc1NC(=O)Nc1nc(nc2c1cccc2)c1cccnc1,"InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)",YRAFEJSZTVWUMD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,<,,,,9767636, A1 receptor,18,P30542,Human,derenofylline,3281,,9953065,O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1,"InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)/t13-,14-",RBZNJGHIKXAKQE-HDJSIYSDSA-N,Antagonist,Antagonist,,,,,pKi,,9.0,,Ki,,1.0,,=,,,,17558436, A1 receptor,18,P25099,Rat,derenofylline,3281,,9953065,O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1,"InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)/t13-,14-",RBZNJGHIKXAKQE-HDJSIYSDSA-N,Antagonist,Antagonist,,,,,pKi,,8.6,,Ki,,2.51,,=,,,,17558436, A1 receptor,18,P30542,Human,SCH442416,3283,,10668061,COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1,"InChI=1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)",AEULVFLPCJOBCE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.95,,Ki,,1110.0,,=,,,,16518376, A1 receptor,18,P30542,Human,PSB603,3284,,44185871,CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl,"InChI=1S/C24H25ClN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33)",OVHCTHHFOHMNFV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,19569717, A1 receptor,18,P25099,Rat,PSB603,3284,,44185871,CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl,"InChI=1S/C24H25ClN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33)",OVHCTHHFOHMNFV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,19569717, A1 receptor,18,P25099,Rat,PSB36,3285,,11689583,OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3,"InChI=1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23)",CIBIXJYFYPFMTN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.9,,Ki,,0.124,,=,,,,14563788, A1 receptor,18,P30542,Human,PSB1115,3286,,5311479,CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O,"InChI=1S/C14H14N4O5S/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23)",UYDRRQPGDSIMNU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,11906291, A1 receptor,18,P25099,Rat,PSB1115,3286,,5311479,CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O,"InChI=1S/C14H14N4O5S/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23)",UYDRRQPGDSIMNU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.66,,Ki,,2200.0,,=,,,,8230124, A1 receptor,18,P25099,Rat,GR79236,3288,,9884817,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1CCC[C@@H]1O,"InChI=1S/C15H21N5O5/c21-4-9-11(23)12(24)15(25-9)20-6-18-10-13(16-5-17-14(10)20)19-7-2-1-3-8(7)22/h5-9,11-12,15,21-24H,1-4H2,(H,16,17,19)/t7-,8-,9+,11+,12+,15+/m0/s1",GYWXTRVEUURNEW-TVDBPQCTSA-N,Agonist,Agonist,,,,,pKi,,8.51,,Ki,,3.1,,=,,,,16518376, A1 receptor,18,P30542,Human,BAY 60-6583,3289,,11717831,N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N,"InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)",ZTYHZMAZUWOXNC-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,17632123, A1 receptor,18,P30542,Human,apadenoson,3290,,9805430,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(C#CC[C@@H]1CC[C@H](CC1)C(=O)OC)nc2N,"InChI=1S/C23H30N6O6/c1-3-25-21(32)18-16(30)17(31)22(35-18)29-11-26-15-19(24)27-14(28-20(15)29)6-4-5-12-7-9-13(10-8-12)23(33)34-2/h11-13,16-18,22,30-31H,3,5,7-10H2,1-2H3,(H,25,32)(H2,24,27,28)/t12-,13-,16-,17+,18-,22+/m0/s1",FLEVIENZILQUKB-XTWQNQIISA-N,Agonist,Agonist,,,,,pKi,,7.11,,Ki,,77.0,,=,,,,16518376, A1 receptor,18,P30542,Human,mefloquine,4252,,4046,OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1,"InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2",XEEQGYMUWCZPDN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.17,,Ki,,675.0,,=,Binding affinity determined by displacement of [3H]-DPCPX from human A1 receptors by increasing concentrations of racemic mefloquine.,,,14663021, A1 receptor,18,P30542,Human,TCPA,5590,,136218973,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1,"InChI=1S/C22H27N9O5/c32-10-14-16(33)17(34)20(36-14)31-11-23-15-18(24-12-8-4-5-9-12)26-21(27-19(15)31)28-30-29-22(35)25-13-6-2-1-3-7-13/h1-3,6-7,11-12,14,16-17,20,32-34H,4-5,8-10H2,(H3,24,25,26,27,28,29,35)/t14-,16-,17-,20-/m1/s1",RZJAODYQRFMAKN-WVSUBDOOSA-N,Agonist,Agonist,,,,,pKi,,8.55,,Ki,,2.8,,=,,,,12672250, A1 receptor,18,,Pig,tecadenoson,5592,,158795,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1COCC1,"InChI=1S/C14H19N5O5/c20-3-8-10(21)11(22)14(24-8)19-6-17-9-12(15-5-16-13(9)19)18-7-1-2-23-4-7/h5-8,10-11,14,20-22H,1-4H2,(H,15,16,18)/t7-,8-,10-,11-,14-/m1/s1",OESBDSFYJMDRJY-BAYCTPFLSA-N,Agonist,Agonist,,,yes,,pKi,,8.19,,Ki,,6.5,,=,,,,16518376|21185259, A1 receptor,18,P30542,Human,GS9667,5593,,11561692,O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F,"InChI=1S/C21H24FN5O4S/c22-11-4-1-2-7-15(11)32-8-14-17(29)18(30)21(31-14)27-10-25-16-19(23-9-24-20(16)27)26-12-5-3-6-13(12)28/h1-2,4,7,9-10,12-14,17-18,21,28-30H,3,5-6,8H2,(H,23,24,26)/t12-,13-,14-,17-,18-,21-/m1/s1",IZRXENCTXNMAMI-DIJFLQFKSA-N,Agonist,Agonist,,,,,pKi,,7.26,,Ki,,55.0,,=,,,,19012505, A1 receptor,18,P30542,Human,binodenoson,5595,,9576912,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N,"InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1",XJFMHMFFBSOEPR-DNZQAUTHSA-N,Agonist,Agonist,,,,,pKi,,4.32,,Ki,,48000.0,,=,,,,16518376, A1 receptor,18,P30542,Human,regadenoson,5596,,219024,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC,"InChI=1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1",LZPZPHGJDAGEJZ-AKAIJSEGSA-N,Agonist,Agonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,16518376, A1 receptor,18,P30542,Human,"CP608,039",5598,,73977920,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1N)O)n1cnc2c1ncnc2NCc1cc(Cl)ccc1COc1onc(c1)C,"InChI=1S/C23H25ClN8O5/c1-11-5-15(37-31-11)35-8-12-3-4-14(24)6-13(12)7-27-20-17-21(29-9-28-20)32(10-30-17)23-18(33)16(25)19(36-23)22(34)26-2/h3-6,9-10,16,18-19,23,33H,7-8,25H2,1-2H3,(H,26,34)(H,27,28,29)/t16-,18+,19-,23+/m0/s1",KXDJDMIUJGBFAV-QYUDBREXSA-N,Agonist,Agonist,,,,,pKi,,5.14,,Ki,,7300.0,,=,,,,16518376, A1 receptor,18,P30542,Human,HEMADO,5599,,10981286,CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO,"InChI=1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1",KOCIMZNSNPOGOP-IWCJZZDYSA-N,Agonist,Agonist,,,,,pKi,,6.48,,Ki,,330.0,,=,,,,12109910|17126322, A1 receptor,18,P30542,Human,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,6.59,,Ki,,260.0,,=,,,,16518376, A1 receptor,18,Q60612,Mouse,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,7.8,,Ki,,15.8,,=,,,,, A1 receptor,18,P25099,Rat,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,6.98,,Ki,,105.0,,=,,,,, A1 receptor,18,P30542,Human,CPFPX,5603,,5461879,[18F]CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H23FN4O2/c1-2-9-21-15(22)12-14(20(16(21)23)10-5-8-17)19-13(18-12)11-6-3-4-7-11/h11H,2-10H2,1H3,(H,18,19)/i17-1",GGGMDKJPUXTDAW-SJPDSGJFSA-N,Antagonist,Antagonist,,,,,pKi,,8.9,,Ki,,1.26,,=,,,,12408725, A1 receptor,18,P25099,Rat,CPFPX,5603,,5461879,[18F]CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H23FN4O2/c1-2-9-21-15(22)12-14(20(16(21)23)10-5-8-17)19-13(18-12)11-6-3-4-7-11/h11H,2-10H2,1H3,(H,18,19)/i17-1",GGGMDKJPUXTDAW-SJPDSGJFSA-N,Antagonist,Antagonist,,,,,pKi,,9.2,,Ki,,0.63,,=,,,,12408725, A1 receptor,18,P30542,Human,rolofylline,5604,,64627,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3,"InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)",PJBFVWGQFLYWCB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.14,,8.1,Ki,8.0,,0.72,=,,,,17125264|9191953, A1 receptor,18,P25099,Rat,rolofylline,5604,,64627,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3,"InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)",PJBFVWGQFLYWCB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.72,,7.9,Ki,12.6,,0.19,=,,,,9191953, A1 receptor,18,P30542,Human,tonapofylline,5605,,216466,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O,"InChI=1S/C22H32N4O4/c1-3-13-25-17-16(18(29)26(14-4-2)20(25)30)23-19(24-17)22-10-7-21(8-11-22,9-12-22)6-5-15(27)28/h3-14H2,1-2H3,(H,23,24)(H,27,28)",ZWTVVWUOTJRXKM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.13,,Ki,,7.4,,=,,,,17125264, A1 receptor,18,P25099,Rat,tonapofylline,5605,,216466,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O,"InChI=1S/C22H32N4O4/c1-3-13-25-17-16(18(29)26(14-4-2)20(25)30)23-19(24-17)22-10-7-21(8-11-22,9-12-22)6-5-15(27)28/h3-14H2,1-2H3,(H,23,24)(H,27,28)",ZWTVVWUOTJRXKM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.89,,Ki,,1.3,,=,,,,17125264, A1 receptor,18,P30542,Human,FK-453,5606,,6439091,OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1,"InChI=1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1",OPLOPFHUHFGKMJ-JXOMPUQVSA-N,Antagonist,Antagonist,,,,,pKi,,7.74,,Ki,,18.0,,=,,,,16518376, A1 receptor,18,P30542,Human,LUF5981,5607,,16109435,C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1,"InChI=1S/C24H23N3/c1-4-10-17(11-5-1)20-16-21(18-12-6-2-7-13-18)25-24-22(20)26-23(27-24)19-14-8-3-9-15-19/h1-2,4-7,10-13,16,19H,3,8-9,14-15H2,(H,25,26,27)",DXBBMCIVYYJMJC-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.05,,Ki,,0.9,,=,,,,17300165, A1 receptor,18,P30542,Human,istradefylline,5608,,5311037,COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC,"InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+",IQVRBWUUXZMOPW-PKNBQFBNSA-N,Antagonist,Antagonist,,,,,pKi,,6.08,,Ki,,841.0,,=,,,,21303899, A1 receptor,18,P25099,Rat,istradefylline,5608,,5311037,COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC,"InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+",IQVRBWUUXZMOPW-PKNBQFBNSA-N,Antagonist,Antagonist,,,,,pKi,,6.64,,Ki,,230.0,,=,,,,21303899, A1 receptor,18,P25099,Rat,CSC,5609,,5353365,Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C,"InChI=1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-14-13(19)15(22)21(3)16(23)20(14)2/h4-9H,1-3H3/b8-7+",WBWFIUAVMCNYPG-BQYQJAHWSA-N,Antagonist,Antagonist,,,,,pKi,,4.55,,Ki,,28000.0,,=,,,,8496902, A1 receptor,18,P30542,Human,MSX-2,5610,,10046145,OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC,"InChI=1S/C21H22N4O4/c1-4-11-25-20(27)18-19(24(21(25)28)12-6-13-26)22-17(23(18)2)10-9-15-7-5-8-16(14-15)29-3/h1,5,7-10,14,26H,6,11-13H2,2-3H3/b10-9+",FWLDDFYHEQMIGG-MDZDMXLPSA-N,Antagonist,Antagonist,,,,,pKi,,5.6,,Ki,,2500.0,,=,,,,10669571, A1 receptor,18,P25099,Rat,MSX-2,5610,,10046145,OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC,"InChI=1S/C21H22N4O4/c1-4-11-25-20(27)18-19(24(21(25)28)12-6-13-26)22-17(23(18)2)10-9-15-7-5-8-16(14-15)29-3/h1,5,7-10,14,26H,6,11-13H2,2-3H3/b10-9+",FWLDDFYHEQMIGG-MDZDMXLPSA-N,Antagonist,Antagonist,,,,,pKi,,6.05,,Ki,,900.0,,=,,,,10669571, A1 receptor,18,P30542,Human,vipadenant,5612,,21874557,Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N,"InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20)",HQSBCDPYXDGTCL-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.17,,Ki,,68.0,,=,,,,19072055, A1 receptor,18,P30542,Human,ST-1535,5613,,9860294,CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1,"InChI=1S/C12H16N8/c1-3-4-5-8-16-10(13)9-11(17-8)19(2)12(18-9)20-14-6-7-15-20/h6-7H,3-5H2,1-2H3,(H2,13,16,17)",CYYQMAWUIRPCNW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.14,,Ki,,71.8,,=,,,,16250647, A1 receptor,18,P30542,Human,preladenant,5614,,10117987,COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1,"InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)",DTYWJKSSUANMHD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,18221214, A1 receptor,18,P30542,Human,CVT-6883,5615,,11270783,CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F,"InChI=1S/C21H21F3N6O2/c1-3-8-30-19(31)16-18(29(4-2)20(30)32)27-17(26-16)14-10-25-28(12-14)11-13-6-5-7-15(9-13)21(22,23)24/h5-7,9-10,12H,3-4,8,11H2,1-2H3,(H,26,27)",KOYXXLLNCXWUNF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.71,,Ki,,1940.0,,=,,,,18321039, A1 receptor,18,P30542,Human,ATL802,5616,,24780383,CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C,"InChI=1S/C24H22F3N7O3/c1-3-10-33-20-18(22(36)34(23(33)37)15-6-7-15)30-19(31-20)13-5-9-17(29-11-13)32(2)21(35)14-4-8-16(28-12-14)24(25,26)27/h4-5,8-9,11-12,15H,3,6-7,10H2,1-2H3,(H,30,31)",IKIXRBGOWUFFBN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.43,,Ki,,369.0,,=,,,,10737749, A1 receptor,18,Q60612,Mouse,ATL802,5616,,24780383,CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C,"InChI=1S/C24H22F3N7O3/c1-3-10-33-20-18(22(36)34(23(33)37)15-6-7-15)30-19(31-20)13-5-9-17(29-11-13)32(2)21(35)14-4-8-16(28-12-14)24(25,26)27/h4-5,8-9,11-12,15H,3,6-7,10H2,1-2H3,(H,30,31)",IKIXRBGOWUFFBN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.02,,Ki,,9583.0,,=,,,,10737749, A1 receptor,18,P30542,Human,LAS38096,5617,,11716665,n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1,"InChI=1S/C17H12N6O/c1-3-12(9-18-6-1)22-17-20-10-13(14-5-7-19-11-21-14)16(23-17)15-4-2-8-24-15/h1-11H,(H,20,22,23)",YRPIMMMBNUUYLG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.55,,Ki,,2821.0,,=,,,,17469811|20137946, A1 receptor,18,P30542,Human,KF26777,5618,,135409562,CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br,"InChI=1S/C16H16BrN5O/c1-2-8-21-15-12(14-18-7-9-22(14)16(21)23)19-13(20-15)10-3-5-11(17)6-4-10/h3-6H,2,7-9H2,1H3,(H,19,20)",GYGNZJDWTHECQT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.74,,Ki,,1800.0,,=,,,,12063073, A1 receptor,18,P30542,Human,PSB-10,5619,,135401232,CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C,"InChI=1S/C16H14Cl3N5O/c1-3-8-6-24-15(20-8)12-14(23(2)16(24)25)22-13(21-12)9-4-7(17)5-10(18)11(9)19/h4-5,8H,3,6H2,1-2H3,(H,21,22)/t8-/m1/s1",YYDHUJWLNPIBDS-MRVPVSSYSA-N,Antagonist,Antagonist,,,,,pKi,,5.77,,Ki,,1700.0,,=,,,,12517430, A1 receptor,18,P25099,Rat,PSB-10,5619,,135401232,CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C,"InChI=1S/C16H14Cl3N5O/c1-3-8-6-24-15(20-8)12-14(23(2)16(24)25)22-13(21-12)9-4-7(17)5-10(18)11(9)19/h4-5,8H,3,6H2,1-2H3,(H,21,22)/t8-/m1/s1",YYDHUJWLNPIBDS-MRVPVSSYSA-N,Antagonist,Antagonist,,,,,pKi,,6.09,,Ki,,805.0,,=,,,,12139454, A1 receptor,18,P30542,Human,PSB-11,5620,,135433658,CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1,"InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)/t11-/m1/s1",RGDHRCXUMURWBJ-LLVKDONJSA-N,Antagonist,Antagonist,,,,,pKi,,5.79,,Ki,,1640.0,,=,,,,12517430, A1 receptor,18,P25099,Rat,PSB-11,5620,,135433658,CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1,"InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)/t11-/m1/s1",RGDHRCXUMURWBJ-LLVKDONJSA-N,Antagonist,Antagonist,,,,,pKi,,6.36,,Ki,,440.0,,=,,,,12517430, A1 receptor,18,P30542,Human,MRS5151,5622,,91827346,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1C#CCCCC(=O)O)Cl,"InChI=1S/C26H27ClN6O5/c1-28-25(38)26-10-16(26)20(21(36)22(26)37)33-13-32-19-23(30-12-31-24(19)33)29-11-14-6-5-8-17(27)15(14)7-3-2-4-9-18(34)35/h5-6,8,12-13,16,20-22,36-37H,2,4,9-11H2,1H3,(H,28,38)(H,34,35)(H,29,30,31)/t16-,20-,21+,22+,26+/m1/s1",CYQQUPOETXXUCK-CSTWGOEFSA-N,Agonist,Agonist,,,,,pKi,,4.83,,Ki,,14900.0,,=,,,,18424135, A1 receptor,18,Q60612,Mouse,MRS5151,5622,,91827346,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1C#CCCCC(=O)O)Cl,"InChI=1S/C26H27ClN6O5/c1-28-25(38)26-10-16(26)20(21(36)22(26)37)33-13-32-19-23(30-12-31-24(19)33)29-11-14-6-5-8-17(27)15(14)7-3-2-4-9-18(34)35/h5-6,8,12-13,16,20-22,36-37H,2,4,9-11H2,1H3,(H,28,38)(H,34,35)(H,29,30,31)/t16-,20-,21+,22+,26+/m1/s1",CYQQUPOETXXUCK-CSTWGOEFSA-N,Agonist,Agonist,,,,,pKi,,4.98,,Ki,,10500.0,,=,,,,18424135, A1 receptor,18,P30542,Human,5-Cl-5-deoxy-(±)-ENBA,6560,,15599147,ClCC1OC(C(C1O)O)n1cnc2c1ncnc2NC1CC2CC1CC2,"InChI=1S/C17H22ClN5O3/c18-5-11-13(24)14(25)17(26-11)23-7-21-12-15(19-6-20-16(12)23)22-10-4-8-1-2-9(10)3-8/h6-11,13-14,17,24-25H,1-5H2,(H,19,20,22)",PVJGDYDNVNCGBT-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.29,,Ki,,0.51,,=,,,,19317449, A1 receptor,18,P30542,Human,WRC-0571,8419,,91827359,OC1CC2CC1C[C@H]2Nc1ncnc2c1nc(n2C)N(C(C)C)C,"InChI=1S/C17H26N6O/c1-9(2)22(3)17-21-14-15(18-8-19-16(14)23(17)4)20-12-6-11-5-10(12)7-13(11)24/h8-13,24H,5-7H2,1-4H3,(H,18,19,20)/t10?,11?,12-,13?/m1/s1",FTVZUYADPTUEKI-AYNROABZSA-N,Antagonist,Antagonist,,,,,pKi,,8.8,,,,,,=,,,,8632314, A1 receptor,18,P30542,Human,VPC171,8895,,24873485,Nc1scc(c1C(=O)c1ccccc1)c1cccc(c1)C(F)(F)F,"InChI=1S/C18H12F3NOS/c19-18(20,21)13-8-4-7-12(9-13)14-10-24-17(22)15(14)16(23)11-5-2-1-3-6-11/h1-10H,22H2",HNHLVOBHWXLIGP-UHFFFAOYSA-N,Allosteric modulator,Positive,,,yes,,,,,,,,,,=,,,,19514747|26104547, A1 receptor,18,P30542,Human,PD81723,9445,,122028,Nc1sc(c(c1C(=O)c1cccc(c1)C(F)(F)F)C)C,"InChI=1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3",KKDKAWKYGCUOGR-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,2174510, A1 receptor,18,P30542,Human,DU172,9530,,10839674,CCCn1c(=O)n(CCCNC(=O)c2ccc(cc2)S(=O)(=O)F)c2c(c1=O)nc([nH]2)C1CCCCC1,"InChI=1S/C24H30FN5O5S/c1-2-14-30-23(32)19-21(28-20(27-19)16-7-4-3-5-8-16)29(24(30)33)15-6-13-26-22(31)17-9-11-18(12-10-17)36(25,34)35/h9-12,16H,2-8,13-15H2,1H3,(H,26,31)(H,27,28)",KAJVJPLKXGLLDA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.4,,,,,,=,,,,28235198, A1 receptor,18,P30542,Human,LUF5962,9813,,11617054,C1CCC(C1)c1[nH]c2c(n1)nc(nc2c1ccccc1)c1ccccc1,"InChI=1S/C22H20N4/c1-3-9-15(10-4-1)18-19-22(26-21(24-19)17-13-7-8-14-17)25-20(23-18)16-11-5-2-6-12-16/h1-6,9-12,17H,7-8,13-14H2,(H,23,24,25,26)",NDJOQVVSPLVIDN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pIC50,,7.13,,,,,,=,,,,29486053, A1 receptor,18,P30542,Human,MRS7469,10235,,137553161,OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1,"InChI=1S/C21H28ClN5O3/c22-20-25-18(24-13(10-3-1-4-10)11-5-2-6-11)14-19(26-20)27(9-23-14)15-12-7-21(12,8-28)17(30)16(15)29/h9-13,15-17,28-30H,1-8H2,(H,24,25,26)/t12-,15-,16+,17+,21+/m1/s1",KATPAPFGRPJUHJ-MXKWNSRKSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,30605331, A1 receptor,18,P30542,Human,LUF7602,10351,,138393285,CCCn1c(=O)c2n3ccc(cc3nc2n(c1=O)CCCCNC(=O)c1ccc(cc1)S(=O)(=O)F)OC,"InChI=1S/C24H26FN5O6S/c1-3-12-30-23(32)20-21(27-19-15-17(36-2)10-14-28(19)20)29(24(30)33)13-5-4-11-26-22(31)16-6-8-18(9-7-16)37(25,34)35/h6-10,14-15H,3-5,11-13H2,1-2H3,(H,26,31)",WUZBOJXXYMKMMF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.1,,Ki,,794.0,,=,Affinity determined from the displacement of specific [3H]DPCPX binding on CHO cell membranes stably expressing human adenosine A1 receptors at 25 °C during 2 h of incubation.,,,30869893, A1 receptor,18,P30542,Human,compound 10 [PMID: 31306001],10443,,139030524,COC(=O)c1cccc(c1)CSc1nc(N)c(c(c1C#N)c1ccco1)C#N,"InChI=1S/C20H14N4O3S/c1-26-20(25)13-5-2-4-12(8-13)11-28-19-15(10-22)17(16-6-3-7-27-16)14(9-21)18(23)24-19/h2-8H,11H2,1H3,(H2,23,24)",IKBOAPCYYHRBSI-UHFFFAOYSA-N,Agonist,Inverse agonist,,,,,pKi,,8.14,,Ki,,7.22,,=,Binding affinity calculated by measuring displacement of specific [3H]DPCPX binding at hA1ARs expressed in CHO cells.,,,31306001, A1 receptor,18,P30542,Human,imaradenant,11153,,86676119,Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl,"InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)",NCWQLHHDGDXIJN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.8,,Ki,,160.0,,=,Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from CHO cells stably expressing human A1R.,,,32727810, A1 receptor,18,P30542,Human,capadenoson,11221,,9936489,OCCOc1ccc(cc1)c1c(C#N)c(SCc2csc(n2)c2ccc(cc2)Cl)nc(c1C#N)N,"InChI=1S/C25H18ClN5O2S2/c26-17-5-1-16(2-6-17)24-30-18(13-34-24)14-35-25-21(12-28)22(20(11-27)23(29)31-25)15-3-7-19(8-4-15)33-10-9-32/h1-8,13,32H,9-10,14H2,(H2,29,31)",CITWCLNVRIKQAF-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pEC50,,10.0,,EC50,,0.1,,=,,,,22081230, A1 receptor,18,P30542,Human,neladenoson,11222,,46847262,OCCOc1ccc(cc1)c1c(C#N)c(SCc2csc(n2)c2ccc(cc2)Cl)nc(c1C#N)N1CCCC1,"InChI=1S/C29H24ClN5O2S2/c30-21-7-3-20(4-8-21)28-33-22(17-38-28)18-39-29-25(16-32)26(19-5-9-23(10-6-19)37-14-13-36)24(15-31)27(34-29)35-11-1-2-12-35/h3-10,17,36H,1-2,11-14,18H2",RFJKJKQQWXKVTD-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pEC50,,10.0,,EC50,,0.1,,=,,,,28488817,