target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id MAPK interacting serine/threonine kinase 2,2105,Q9HBH9,Human,MNK1 inhibitor,6010,,11644425,Fc1ccc(cc1)Nc1[nH]nc2c1c(N)ncn2,"InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)",UQPMANVRZYYQMD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.8,,IC50,,1600.0,,=,,,,20722422, MAPK interacting serine/threonine kinase 2,2105,Q9HBH9,Human,MELK-TI,9366,,73442760,COc1cc(ccc1C(=O)Nc1ccc2c(c1)CCNCC2)c1cn[nH]c1,"InChI=1S/C21H22N4O2/c1-27-20-11-15(17-12-23-24-13-17)3-5-19(20)21(26)25-18-4-2-14-6-8-22-9-7-16(14)10-18/h2-5,10-13,22H,6-9H2,1H3,(H,23,24)(H,25,26)",GMZCYCKIXQZORP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.12,,IC50,,760.0,,=,Measured in a MIllipore kinase screening assay,,,25589925, MAPK interacting serine/threonine kinase 2,2105,Q9HBH9,Human,tomivosertib,10167,,118598754,Nc1ncnc(c1)Nc1cc(C)c2n(c1=O)C1(CCCCC1)NC2=O,"InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)",HKTBYUWLRDZAJK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,=,Biochemical inhibition assay.,,,29526098, MAPK interacting serine/threonine kinase 2,2105,Q9HBH9,Human,tinodasertib,12385,,71766360,C1COCCN1C(=O)c1ccc(cc1)c1cn2c(ncc2c2ccc(cc2)C#N)cc1,"InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2",FWRFPHJSGLYXTD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.07,,IC50,,86.0,,=,,,,29683667,