target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id ribonucleotide reductase catalytic subunit M1,2630,P23921,Human,gemcitabine,4793,,60750,OC[C@H]1O[C@H](C([C@@H]1O)(F)F)n1ccc(nc1=O)N,"InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1",SDUQYLNIPVEERB-QPPQHZFASA-N,Inhibitor,Inhibition,,,yes,,,,,,,,,,=,,,,2233693, ribonucleotide reductase catalytic subunit M1,2630,P23921,Human,fludarabine,4802,,657237,OC[C@H]1O[C@H]([C@H]([C@@H]1O)O)n1cnc2c1nc(F)nc2N,"InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1",HBUBKKRHXORPQB-FJFJXFQQSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.0,,IC50,,1000.0,,=,Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells,,,7048062, ribonucleotide reductase catalytic subunit M1,2630,P23921,Human,clofarabine,6802,,119182,OC[C@H]1O[C@H]([C@H]([C@@H]1O)F)n1cnc2c1nc(Cl)nc2N,"InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1",WDDPHFBMKLOVOX-AYQXTPAHSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.3,,IC50,,5.0,,=,Inhibition of K562 cell growth,,,1707752, ribonucleotide reductase catalytic subunit M1,2630,P23921,Human,hydroxyurea,6822,,3657,NC(=O)NO,"InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)",VSNHCAURESNICA-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,3.83,,IC50,,148000.0,,=,"Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme",,,15670581, ribonucleotide reductase catalytic subunit M1,2630,P23921,Human,TAS1553,12113,,132203319,C[C@@H]([C@H](NS(=O)(=O)c1ccc(Cl)cc1C(=O)N)c1n[nH]c(=O)o1)c1c(C)c(C)ccc1F,"InChI=1S/C20H20ClFN4O5S/c1-9-4-6-14(22)16(10(9)2)11(3)17(19-24-25-20(28)31-19)26-32(29,30)15-7-5-12(21)8-13(15)18(23)27/h4-8,11,17,26H,1-3H3,(H2,23,27)(H,25,28)/t11-,17+/m1/s1",DUYRWEBTZNUILI-DIFFPNOSSA-N,Inhibitor,Binding,,,,,pKd,,7.46,,Kd,,35.0,,=,Binding affinity for human R1 subunit determined by SPR,,,35681099,