target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium falciparum,DSM265,9644,,51347395,Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2c(n1)nc(n2)C(F)(F)C,"InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3",OIZSVTOIBNSVOS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.52,,IC50,,30.0,,=,Steady-state kinetic analysis.,,,32248693, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium vivax,DSM265,9644,,51347395,Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2c(n1)nc(n2)C(F)(F)C,"InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3",OIZSVTOIBNSVOS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.14,,IC50,,72.0,,=,Steady-state kinetic analysis.,,,32248693, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium falciparum,DSM421,10020,,122552662,Cc1cc(Nc2ccc(nc2)C(F)(F)F)n2c(n1)nc(n2)C(F)(F)C,"InChI=1S/C14H11F5N6/c1-7-5-10(22-8-3-4-9(20-6-8)14(17,18)19)25-12(21-7)23-11(24-25)13(2,15)16/h3-6,22H,1-2H3",HDLFZCDEGAWEFX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.28,,IC50,,53.0,,=,Steady-state kinetic analysis of recombinant enzyme inhibition.,,,27641613, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium vivax,DSM421,10020,,122552662,Cc1cc(Nc2ccc(nc2)C(F)(F)F)n2c(n1)nc(n2)C(F)(F)C,"InChI=1S/C14H11F5N6/c1-7-5-10(22-8-3-4-9(20-6-8)14(17,18)19)25-12(21-7)23-11(24-25)13(2,15)16/h3-6,22H,1-2H3",HDLFZCDEGAWEFX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.03,,IC50,,94.0,,=,Steady-state kinetic analysis of recombinant enzyme inhibition.,,,27641613, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium falciparum,DSM502,11219,,154699462,O=C(c1[nH]cc(c1C)Cc1ccc(nc1)C(F)(F)F)NC1CC1,"InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23)",AFOVOYRODSYDMK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.7,,IC50,,20.0,,=,Steady-state kinetic analysis.,,,32248693, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium vivax,DSM502,11219,,154699462,O=C(c1[nH]cc(c1C)Cc1ccc(nc1)C(F)(F)F)NC1CC1,"InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23)",AFOVOYRODSYDMK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.85,,IC50,,14.0,,=,Steady-state kinetic analysis.,,,32248693, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium falciparum,BRD9185,11469,,121596187,CCCNC(=O)N1[C@H](CO)[C@H]([C@H]1C#N)c1ccc(cc1)c1ccc(c(c1)C(F)(F)F)C(F)(F)F,"InChI=1S/C23H21F6N3O2/c1-2-9-31-21(34)32-18(11-30)20(19(32)12-33)14-5-3-13(4-6-14)15-7-8-16(22(24,25)26)17(10-15)23(27,28)29/h3-8,10,18-20,33H,2,9,12H2,1H3,(H,31,34)/t18-,19-,20+/m1/s1",FYPZBZFXJUJJRA-AQNXPRMDSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.92,,IC50,,12.0,,=,,,,28435533, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium falciparum,DSM705,11554,,155908677,O=C(c1[nH]cc(c1C)C1(CC1)c1ccc(nc1)C(F)(F)F)N[C@@H](c1ncn[nH]1)C,"InChI=1S/C19H19F3N6O/c1-10-13(8-24-15(10)17(29)27-11(2)16-25-9-26-28-16)18(5-6-18)12-3-4-14(23-7-12)19(20,21)22/h3-4,7-9,11,24H,5-6H2,1-2H3,(H,27,29)(H,25,26,28)/t11-/m1/s1",JUBPRXDFKLPILK-LLVKDONJSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.02,,IC50,,95.0,,=,Steady-state kinetic analysis.,,,33876936, Plasmodium falciparum dihydroorotate dehydrogenase,2949,,Plasmodium vivax,DSM705,11554,,155908677,O=C(c1[nH]cc(c1C)C1(CC1)c1ccc(nc1)C(F)(F)F)N[C@@H](c1ncn[nH]1)C,"InChI=1S/C19H19F3N6O/c1-10-13(8-24-15(10)17(29)27-11(2)16-25-9-26-28-16)18(5-6-18)12-3-4-14(23-7-12)19(20,21)22/h3-4,7-9,11,24H,5-6H2,1-2H3,(H,27,29)(H,25,26,28)/t11-/m1/s1",JUBPRXDFKLPILK-LLVKDONJSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.28,,IC50,,52.0,,=,Steady-state kinetic analysis.,,,33876936,