target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id "indoleamine 2,3-dioxygenase 2",3019,Q6ZQW0,Human,tryptanthrin 5i,10126,,478573,[O-][N+](=O)c1ccc2c(c1)C(=O)c1n2c(=O)c2c(n1)cccc2,InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H,UFMQJYHLIUACCG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.35,,IC50,,450.0,,=,Inhibition of enzyme activity when hIDO2 is expressed in U87 human glioblastoma cells.,,,27475108, "indoleamine 2,3-dioxygenase 2",3019,Q6ZQW0,Human,tryptanthrin 5i,10126,,478573,[O-][N+](=O)c1ccc2c(c1)C(=O)c1n2c(=O)c2c(n1)cccc2,InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H,UFMQJYHLIUACCG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.74,,IC50,,1800.0,,=,Inhibition of enzymatic activity of recombinant human IDO2.,,,27475108, "indoleamine 2,3-dioxygenase 2",3019,Q6ZQW0,Human,tryptanthrin 5i,10126,,478573,[O-][N+](=O)c1ccc2c(c1)C(=O)c1n2c(=O)c2c(n1)cccc2,InChI=1S/C15H7N3O4/c19-13-10-7-8(18(21)22)5-6-12(10)17-14(13)16-11-4-2-1-3-9(11)15(17)20/h1-7H,UFMQJYHLIUACCG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,6.01,,Ki,,970.0,,=,,,,27475108, "indoleamine 2,3-dioxygenase 2",3019,Q6ZQW0,Human,example 184 [WO2014186035],12668,,86280679,NC=1OC2=C(C3=CC=NC=C3)N=CC=C2C1NC4=CC=C(F)C(F)=C4,"InChI=1S/C18H12F2N4O/c19-13-2-1-11(9-14(13)20)24-16-12-5-8-23-15(17(12)25-18(16)21)10-3-6-22-7-4-10/h1-9,24H,21H2",YZPRNUIZJURTKK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.0,,IC50,,1000.0,,<,"Inhibition of recombinant human IDO2 (14-420)-mediated kynurenine formation from tryptophan, detected by LC/MS/MS analysis",,,,