target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id SST2 receptor,356,P30874,Human,cortistatin-14,2007,"Mouse, Rat",,,,,Agonist,Full agonist,,yes,,,pKi,9.0,,8.4,,,,,,,,,9650799|10598788|9652348, SST2 receptor,356,P30874,Human,CST-17,2008,Human,,,,,Agonist,Full agonist,,yes,,,pKi,9.3,,8.8,,,,,,,,,9650799|10598788|15333679, SST2 receptor,356,P30680,Rat,pasireotide,2018,,9941444,NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)OCc1ccccc1)Cc1ccccc1)C[C@@H](C2)OC(=O)NCCN)c1ccccc1)Cc1c[nH]c2c1cccc2,"InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1",VMZMNAABQBOLAK-DBILLSOUSA-N,Agonist,Agonist,,,,,pEC50,9.07,,7.76,EC50,17.5,,0.86,=,,,,19910453|21493671, SST2 receptor,356,P30874,Human,SRIF-14,2019,"Human, Mouse, Rat",44386062,NCCCC[C@H]1NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CCCCN)[C@H](O)C)C(=O)O)NC(=O)CNC(=O)[C@@H](N)C,"InChI=1S/C63H88N16O16S2/c1-34(66)53(84)69-30-51(83)70-48-32-96-97-33-49(63(94)95)78-60(91)47(31-80)77-62(93)52(35(2)81)79-55(86)42(22-12-14-24-65)71-58(89)45(27-38-29-68-40-20-10-9-19-39(38)40)75-57(88)44(26-37-17-7-4-8-18-37)73-56(87)43(25-36-15-5-3-6-16-36)74-59(90)46(28-50(67)82)76-54(85)41(72-61(48)92)21-11-13-23-64/h3-10,15-20,29,34-35,41-49,52,68,80-81H,11-14,21-28,30-33,64-66H2,1-2H3,(H2,67,82)(H,69,84)(H,70,83)(H,71,89)(H,72,92)(H,73,87)(H,74,90)(H,75,88)(H,76,85)(H,77,93)(H,78,91)(H,79,86)(H,94,95)/t34-,35+,41+,42-,43+,44-,45+,46-,47-,48+,49-,52+/m0/s1",VVEJUSYNERNRME-XGFVQVCISA-N,Agonist,Full agonist,,yes,,,pKi,10.5,,8.9,,,,,,,,,8769372|15333679|7988476|11520208|9784130|9652348|9650799|9724791|10598788, SST2 receptor,356,P30874,Human,SRIF-28,2020,"Human, Mouse, Rat",16133849,NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCCN)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CCCCN)[C@H](O)C)[C@H](O)C)C(=O)O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)C)CC(=O)N)CO)CC(=O)N)C)CCSC)C)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N,"InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/m0/s1",GGYTXJNZMFRSLX-DFTNLTQTSA-N,Agonist,Full agonist,,yes,,,pKi,10.2,,8.4,,,,,,,,,8769372|9650799|10598788|15333679|7988476|9652348, SST2 receptor,356,P30874,Human,[125I]LTT-SRIF-28,2023,,,,,,Agonist,Full agonist,,,,,pKd,10.0,,9.9,,,,,=,,,,9784130|9650799|9652348, SST2 receptor,356,P30874,Human,[125I]Tyr10-CST14,2024,,,,,,Agonist,Full agonist,,,,,pKd,,9.4,,,,,,,,,,9650799|10598788, SST2 receptor,356,P30874,Human,BIM 23454,2026,,,,,,Antagonist,Antagonist,,,,,pIC50,,7.5,,,,,,,,,,11897676, SST2 receptor,356,P30874,Human,BIM 23627,2027,,,,,,Antagonist,Antagonist,,,,,pIC50,,8.2,,,,,,=,,,,11897676, SST2 receptor,356,P30874,Human,[D-Tyr8]CYN 154806,2028,,,,,,Antagonist,Antagonist,,,,,pKd,8.9,,8.1,,,,,=,,,,12616335, SST2 receptor,356,P30874,Human,lanreotide,2031,,71349,NCCCCC1NC(=O)C(NC(=O)C(Cc2ccc(cc2)O)NC(=O)C(CSSCC(NC(=O)C(NC1=O)C(C)C)C(=O)NC(C(=O)N)C(O)C)NC(=O)C(Cc1ccc2c(c1)cccc2)N)Cc1c[nH]c2c1cccc2,"InChI=1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)",PUDHBTGHUJUUFI-UHFFFAOYSA-N,Agonist,Full agonist,,,yes,,pKi,9.6,,8.7,,,,,=,,,,8769372|9650799|10598788|7988476|9652348, SST2 receptor,356,P30874,Human,BIM 23023,2032,,,,,,Agonist,Full agonist,,,,,pKi,,9.4,,,,,,,,,,7988476, SST2 receptor,356,P30874,Human,BIM 23056,2036,,,,,,Agonist,Full agonist,,,,,pKi,6.7,,6.2,,,,,,,,,8769372|9650799|10598788|9652348, SST2 receptor,356,P30874,Human,BIM 23059,2037,,,,,,Agonist,Full agonist,,,,,pKi,,9.4,,,,,,,,,,7988476, SST2 receptor,356,P30874,Human,BIM 23068,2040,,,,,,Agonist,Full agonist,,,,,pKi,,8.8,,,,,,,,,,7988476, SST2 receptor,356,P30874,Human,[111In]DOTA-NOC,2045,,,,,,Agonist,Full agonist,,,,,pIC50,,8.5,,,,,,,,,,12937948, SST2 receptor,356,P30874,Human,"L-054,522",2046,,15965425,NCCCC[C@@H](C(=O)OC(C)(C)C)NC(=O)[C@@H]([C@H](c1c[nH]c2c1cccc2)C)NC(=O)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2,"InChI=1S/C35H47N7O5/c1-22(25-21-37-26-12-6-5-11-24(25)26)30(31(43)38-28(14-9-10-18-36)32(44)47-35(2,3)4)40-33(45)41-19-16-23(17-20-41)42-29-15-8-7-13-27(29)39-34(42)46/h5-8,11-13,15,21-23,28,30,37H,9-10,14,16-20,36H2,1-4H3,(H,38,43)(H,39,46)(H,40,45)/t22-,28-,30+/m0/s1",WFCIXKAZBUIFTR-PKIMSIDOSA-N,Agonist,Full agonist,,,,,pKi,,11.0,,,,,,=,,,,9724791, SST2 receptor,356,P30874,Human,"L-363,377",2048,,70692642,,,,Agonist,Full agonist,,,,,pKi,,9.3,,,,,,,,,,9784130|9724791, SST2 receptor,356,P30874,Human,"L-779,976",2050,,5311372,NC[C@@H]1CCC[C@H](C1)CNC(=O)[C@@H]([C@H](c1c[nH]c2c1cccc2)C)NC(=O)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2,"InChI=1S/C33H43N7O3/c1-21(26-20-35-27-10-3-2-9-25(26)27)30(31(41)36-19-23-8-6-7-22(17-23)18-34)38-32(42)39-15-13-24(14-16-39)40-29-12-5-4-11-28(29)37-33(40)43/h2-5,9-12,20-24,30,35H,6-8,13-19,34H2,1H3,(H,36,41)(H,37,43)(H,38,42)/t21-,22+,23+,30+/m0/s1",DDVPVAOEMZRZQU-JONNCTARSA-N,Agonist,Full agonist,,,,,pKi,,10.3,,,,,,=,,,,9784130, SST2 receptor,356,P30874,Human,octreotide,2055,,383414,NCCCCC1NC(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)C(CSSCC(NC(=O)C(NC1=O)C(O)C)C(=O)NC(C(O)C)CO)NC(=O)C(Cc1ccccc1)N)Cc1c[nH]c2c1cccc2,"InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)",DEQANNDTNATYII-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,9.9,,8.7,,,,,=,,,,8769372|9650799|10598788|7988476|9724791|9652348, SST2 receptor,356,P30874,Human,"[111In,90Y]DOTA-NOC",2057,,,,,,Agonist,Full agonist,,,,,pIC50,,8.4,,,,,,,,,,12937948, SST2 receptor,356,P30874,Human,"[111In,90Y]DOTA-TOC",2059,,,,,,Agonist,Full agonist,,,,,pIC50,,7.9,,,,,,,,,,12937948, SST2 receptor,356,P30874,Human,[125I]Tyr3 SMS 201-995,2062,,,,,,Agonist,Full agonist,,,,,pIC50,,8.89,,IC50,,1.3,,=,,,,11807604, SST2 receptor,356,P30874,Human,[125I]Tyr3 SMS 201-995,2062,,,,,,Agonist,Full agonist,,,,,pKd,,9.9,,Kd,,0.13,,=,,,,10598788|9652348, SST2 receptor,356,P30874,Human,[111In]DOTA-BOC-ATE,2063,,,,,,Agonist,Full agonist,,,,,pIC50,,8.8,,,,,,,,,,15709181, SST2 receptor,356,P30874,Human,[111In]DOTA-NOC-ATE,2064,,,,,,Agonist,Full agonist,,,,,pIC50,,8.7,,,,,,,,,,15709181, SST2 receptor,356,P30874,Human,"[125I][Tyr3,Thr8]octreotide",5630,,,,,,Agonist,Full agonist,,,,,pIC50,,9.33,,IC50,,0.47,,=,,,,11807604, SST2 receptor,356,P30874,Human,"[Ga-DOTA,Tyr3,Thr8]octreotide",5632,,,,,,Agonist,Full agonist,,,,,pIC50,,9.7,,IC50,,0.2,,=,,,,17225119|10774879, SST2 receptor,356,P30874,Human,BASS antagonist,5644,,,,,,Antagonist,Antagonist,,,,,pKi,,9.52,,Ki,,0.3,,=,,,,8863814, SST2 receptor,356,P30874,Human,veldoreotide,8487,,9919857,NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCNC(=O)CCCN(C(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@H](O)C)Cc1ccccc1)CC(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2,"InChI=1S/C60H74N12O10/c1-37(73)54-59(81)70-50(31-39-18-6-3-7-19-39)60(82)72(36-51(62)74)29-15-26-52(75)63-28-14-25-53(76)66-47(30-38-16-4-2-5-17-38)56(78)68-49(33-41-35-65-45-23-11-9-21-43(41)45)58(80)69-48(32-40-34-64-44-22-10-8-20-42(40)44)57(79)67-46(55(77)71-54)24-12-13-27-61/h2-11,16-23,34-35,37,46-50,54,64-65,73H,12-15,24-33,36,61H2,1H3,(H2,62,74)(H,63,75)(H,66,76)(H,67,79)(H,68,78)(H,69,80)(H,70,81)(H,71,77)/t37-,46+,47+,48-,49+,50+,54+/m1/s1",ABFNTRQPWNXUHA-VEVJRHMJSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,11145612, SST2 receptor,356,P30874,Human,DOTA-JR11,10113,,,,,,Antagonist,Antagonist,,,,,,,,,,,,,=,,,,18543899,