target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TRH1 receptor,363,P34981,Human,MeTRH,2137,,5311291,O=C(N1CCC[C@H]1C(=O)N)[C@@H](NC(=O)[C@@H]1CCC(=O)N1C)Cc1[nH]cnc1,"InChI=1S/C17H24N6O4/c1-22-13(4-5-14(22)24)16(26)21-11(7-10-8-19-9-20-10)17(27)23-6-2-3-12(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,19,20)(H,21,26)/t11-,12-,13-/m0/s1",DJLHRAHTTSWYAW-AVGNSLFASA-N,Agonist,Partial agonist,,,,,pKi,,8.5,,,,,,=,,,,5001013, TRH1 receptor,363,Q01717,Rat,TRH,2139,"Human, Mouse, Rat",638678,O=C1CC[C@H](N1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1nc[nH]c1,"InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1",XNSAINXGIQZQOO-SRVKXCTJSA-N,Agonist,Full agonist,,yes,yes,,pKi,,7.4,,,,,,=,,,,8592728, TRH1 receptor,363,Q01717,Rat,[3H]MeTRH,2141,,5311291,O=C(N1CCC[C@H]1C(=O)N)[C@@H](NC(=O)[C@@H]1CCC(=O)N1C)Cc1[nH]cnc1,"InChI=1S/C17H24N6O4/c1-22-13(4-5-14(22)24)16(26)21-11(7-10-8-19-9-20-10)17(27)23-6-2-3-12(23)15(18)25/h8-9,11-13H,2-7H2,1H3,(H2,18,25)(H,19,20)(H,21,26)/t11-,12-,13-/m0/s1",DJLHRAHTTSWYAW-AVGNSLFASA-N,Agonist,Partial agonist,,,,,pKd,,8.5,,,,,,=,,,,6264336, TRH1 receptor,363,P34981,Human,taltirelin,2143,,114750,CN1C(=O)C[C@H](NC1=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1[nH]cnc1,"InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1",LQZAIAZUDWIVPM-SRVKXCTJSA-N,Agonist,Full agonist,,,,,pKi,,6.5,,,,,,=,,,,23087672, TRH1 receptor,363,Q01717,Rat,midazolam,3342,,4192,Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F,"InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3",DDLIGBOFAVUZHB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.49,,Ki,,3200.0,,=,,,,2566295, TRH1 receptor,363,P21761,Mouse,chlordiazepoxide,3370,,2712,CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl,"InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)",ANTSCNMPPGJYLG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.7,,Ki,,20000.0,,=,,,,2175902, TRH1 receptor,363,Q01717,Rat,chlordiazepoxide,3370,,2712,CNC1=Nc2ccc(cc2C(=[N+](C1)[O-])c1ccccc1)Cl,"InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)",ANTSCNMPPGJYLG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.82,,Ki,,15000.0,,=,,,,2566295,