target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id glycine receptor α3 subunit,425,O75311,Human,strychnine,347,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Antagonist,Antagonist,,,,,,,,,,,,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,Zn2+,566,,32051,,,,Allosteric modulator,Inhibition,endogenous,yes,,,pIC50,,3.8,,IC50,,150000.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,HU-210,731,,9821569,CCCCCCC(c1cc(O)c2c(c1)OC([C@H]1[C@H]2CC(=CC1)CO)(C)C)(C)C,"InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m1/s1",SSQJFGMEZBFMNV-WOJBJXKFSA-N,Antagonist,Antagonist,,,,,pIC50,,7.3,,IC50,,50.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,WIN55212-2,733,,5311501,O=C(c1c(C)n2c3c1cccc3OC[C@H]2CN1CCOCC1)c1cccc2c1cccc2,"InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1",HQVHOQAKMCMIIM-HXUWFJFHSA-N,Antagonist,Antagonist,,,,,pIC50,,7.0,,IC50,,97.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,onternabez,746,,9844711,CCCCCCC(c1cc(OC)c(c(c1)OC)[C@H]1C=C(CO)[C@@H]2C[C@H]1C2(C)C)(C)C,"InChI=1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21-,22+/m0/s1",CFMRIVODIXTERW-FDFHNCONSA-N,Antagonist,Antagonist,,,,,pIC50,,7.0,,IC50,,97.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,ginkgolide B,1862,,441294,O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C,"InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9?,10?,11+,15+,17?,18?,19-,20-/m1/s1",SQOJOAFXDQDRGF-OOHPMXMZSA-N,Channel blocker,None,,,,,pIC50,,5.7,,IC50,,1800.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,picrotoxinin,2291,,442292,CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]1([C@]3([C@@H]2OC(=O)[C@]23[C@@H](C1)O2)C)O,"InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8-,9-,10-,13-,14-,15+/m1/s1",PIMZUZSSNYHVCU-YKWPQBAZSA-N,Channel blocker,None,,,,,pIC50,,6.4,,IC50,,430.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,[3H]strychnine,2360,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Antagonist,Antagonist,,,,,,,,,,,,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,Δ9-tetrahydrocannabinol,2424,,16078,CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C,"InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1",CYQFCXCEBYINGO-IAGOWNOFSA-N,Allosteric modulator,Potentiation,~1500% potentiation,,,,pEC50,,5.3,,EC50,,5000.0,,~,,,,, glycine receptor α3 subunit,425,O75311,Human,nifedipine,2514,,4485,COC(=O)C1=C(C)NC(=C(C1c1ccccc1[N+](=O)[O-])C(=O)OC)C,"InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3",HYIMSNHJOBLJNT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pIC50,,4.5,,IC50,,29200.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,picrotoxin,4051,,31304,CC(=C)[C@@H]1C2OC(=O)C1[C@]1([C@]3([C@@H]2OC(=O)[C@]23C(C1)O2)C)O.O=C1OC2[C@H](C1[C@]1(O)C[C@@H]3[C@]4([C@@]1([C@@H]2OC4=O)C)O3)C(O)(C)C,"InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1",VJKUPQSHOVKBCO-ZTYBEOBUSA-N,Channel blocker,None,block is weaker when β subunit is co-expressed,,,,,,,,,,,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,"(12E,20Z,18S)-8-hydroxyvariabilin",4072,,54726845,C/C(=C\CCC(CCCc1cocc1)(O)C)/CCC[C@@H](/C=C/1\OC(=O)C(=C1O)C)C,"InChI=1S/C25H36O5/c1-18(8-5-9-19(2)16-22-23(26)20(3)24(27)30-22)10-6-13-25(4,28)14-7-11-21-12-15-29-17-21/h10,12,15-17,19,26,28H,5-9,11,13-14H2,1-4H3/b18-10+,22-16-/t19-,25?/m0/s1",QFBUNOKEKXMSCV-UYYPKTQPSA-N,Antagonist,Antagonist,,,,,pIC50,,5.2,,IC50,,7000.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,Cu2+,4164,,,,,,Allosteric modulator,Inhibition,endogenous,yes,,,pIC50,,5.0,,IC50,,9000.0,,=,,,,, glycine receptor α3 subunit,425,O75311,Human,picrotin,4286,,442291,O=C1O[C@@H]2[C@H]([C@H]1[C@]1(O)C[C@@H]3[C@]4([C@@]1([C@@H]2OC4=O)C)O3)C(O)(C)C,"InChI=1S/C15H18O7/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9/h5-9,18-19H,4H2,1-3H3/t5-,6+,7-,8-,9-,13-,14-,15+/m1/s1",RYEFFICCPKWYML-QCGISDTRSA-N,Channel blocker,None,,,,,pIC50,,5.2,,IC50,,6000.0,,=,,,,,